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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically
DOI: 10.1016/j.canlet.2011.12.041
Abstract: Valproic acid (VPA) has extensive effects on leukemic blasts through its inhibition of histone deacetylases. The main goal of this study was to identify the subgroup of patients who may bene...
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Michal Zapotocky,
Ester Mejstrikova,
Karel Smetana,
Jan Stary,
Jan Trka,
Julia Starkova
et al.
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Full-length article
(In Press Corrected Proof)
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06 February 2012 |
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Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition
DOI: 10.1016/j.canlet.2012.01.015
Abstract: Although pre-clinical and clinical studies on PARP1 inhibitors, alone and in combination with DNA-damaging agents, show promising results, further ways to improve and broaden the scope of ap...
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Siker Kimbung,
Ewa Biskup,
Ida Johansson,
Kristina Aaltonen,
Astrid Ottosson-Wadlund,
Sofia Gruvberger-Saal,
Heather Cunliffe,
Bengt Fadeel,
Niklas Loman,
Pontus Berglund,
Ingrid Hedenfalk
et al.
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Full-length article
(In Press Corrected Proof)
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06 February 2012 |
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A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth
DOI: 10.1016/j.canlet.2011.12.042
Abstract: Although surgical resection with adjuvant chemotherapy and/or radiotherapy are used to treat breast tumors, normal tissue tolerance, development of metastases, and inherent tumor resistance ...
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Gene L. Bidwell,
Eddie Perkins,
Drazen Raucher
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Full-length article
(In Press Corrected Proof)
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06 February 2012 |
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Chmp1A acts as a tumor suppressor gene that inhibits proliferation of renal cell carcinoma
DOI: 10.1016/j.canlet.2012.01.010
Abstract: Renal cell carcinoma (RCC) is a highly malignant and often fatal disease of the kidney. Chmp1A is a member of the Endosomal Sorting Complex Required for Transport (ESCRT-III) family, and pla...
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Zhenqiang You,
Yanfei Xin,
Yan Liu,
Junying Sun,
Guoliang Zhou,
Haiyan Gao,
Pansheng Xu,
Yunxiang Chen,
Guochan Chen,
Lijiang Zhang,
Liqiang Gu,
Zhiqin Chen,
Bin Han,
Yaoxian Xuan
et al.
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Full-length article
(In Press Corrected Proof)
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06 February 2012 |
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Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling
DOI: 10.1016/j.canlet.2011.12.043
Abstract: Sorafenib is a multi-kinase inhibitor applicable to hepatocellular carcinoma (HCC), but its limited therapeutic effects are a major problem to be solved. Here, we show that blockade of ataxi...
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Shun Fujimaki,
Yasunobu Matsuda,
Toshifumi Wakai,
Ayumi Sanpei,
Masayuki Kubota,
Masaaki Takamura,
Satoshi Yamagiwa,
Masahiko Yano,
Shogo Ohkoshi,
Yutaka Aoyagi
et al.
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Full-length article
(In Press Corrected Proof)
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03 February 2012 |
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The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells
DOI: 10.1016/j.canlet.2012.01.002
Abstract: To better understand the response of HCC to EGFR inhibition, we analyzed factors connected to the resistance of HCC cells against gefitinib. Sensitive HCC3 cells co-expressed EGFR and ErbB3 ...
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Annemarie Losert,
Daniela Lötsch,
Andreas Lackner,
Herwig Koppensteiner,
Barbara Peter-Vörösmarty,
Elisabeth Steiner,
Klaus Holzmann,
Thomas Grunt,
Katharina Schmid,
Brigitte Marian,
Bettina Grasl-Kraupp,
Rolf Schulte-Hermann,
Georg Krupitza,
Walter Berger,
Michael Grusch
et al.
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Full-length article
(In Press Corrected Proof)
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03 February 2012 |
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PTEN in DNA damage repair
DOI: 10.1016/j.canlet.2012.01.003
Abstract: The ability of DNA repair in a cell is vital to its genomic integrity and thus to the normal functioning of an organism. Phosphatase and tensin homolog (PTEN) is a well-established tumor sup...
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Mei Ming,
Yu-Ying He
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Short survey
(In Press Corrected Proof)
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03 February 2012 |
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Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations
DOI: 10.1016/j.canlet.2012.01.011
Abstract: The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated molecular pathways in human cancers. Despite its well-established importance in tumor growth, progression ...
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Woody Han,
Hui-Wen Lo
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Short survey
(In Press Corrected Proof)
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03 February 2012 |
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CEA promoter-regulated oncolytic adenovirus-mediated Hsp70 expression in immune gene therapy for pancreatic cancer
DOI: 10.1016/j.canlet.2012.01.009
Abstract: Gene therapy is an important means for the comprehensive treatment of pancreatic cancer. Challenges associated with gene therapy include control of vector security and effective genetic scre...
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Can Xu,
Yunliang Sun,
Yunfeng Wang,
Yan Yan,
Zhengjie Shi,
Lei Chen,
Han Lin,
Shunli Lü,
Maoling Zhu,
Changqing Su,
Zhaoshen Li
et al.
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Full-length article
(In Press Corrected Proof)
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03 February 2012 |
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Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells
DOI: 10.1016/j.canlet.2012.01.013
Abstract: Ras gene is frequently mutated, and also associated with increased Ras expression and its GTPase activity (activity) in pancreatic cancer (PC), which could in part be due to deregulated expr...
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Shadan Ali,
Aamir Ahmad,
Amro Aboukameel,
Bin Bao,
Subhash Padhye,
Philip A. Philip,
Fazlul H. Sarkar
et al.
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Full-length article
(In Press Corrected Proof)
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02 February 2012 |
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Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression
DOI: 10.1016/j.canlet.2012.01.012
Abstract: All-trans retinoic acid (ATRA) is a promising therapeutic agent, but exhibits low efficacy against human cancers. We investigated the effect of sphingosine-1-phosphate (S1P) on ATRA activity...
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De-Fu Sun,
Zu-Hua Gao,
Hui-Ping Liu,
Yi Yuan,
Xian-Jun Qu
et al.
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Full-length article
(In Press Corrected Proof)
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02 February 2012 |
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Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair
DOI: 10.1016/j.canlet.2012.01.004
Abstract: The knockdown of Pim-1 or inhibition of Pim-1 activity significantly increased γ-H2A.X expression. The effect was correlated to apoptosis and was attributed to the inhibition of nonhomologou...
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Jui-Ling Hsu,
Pui-Kei Leong,
Yunn-Fang Ho,
Lih-Ching Hsu,
Pin-Hsuan Lu,
Ching-Shih Chen,
Jih-Hwa Guh
et al.
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Full-length article
(In Press Corrected Proof)
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02 February 2012 |
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Biophotonic techniques for manipulation and characterization of drug delivery nanosystems in cancer therapy
DOI: 10.1016/j.canlet.2011.12.039
Abstract: Reactive oxygen species (ROS) are usually involved in two opposite procedures related to cancer: initiation, progression and metastasis of cancer, as well as in all non-surgical therapeutic ...
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E. Spyratou,
M. Makropoulou,
E.A. Mourelatou,
C. Demetzos
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Short survey
(In Press Corrected Proof)
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02 February 2012 |
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mTOR inhibitors in cancer therapy
DOI: 10.1016/j.canlet.2012.01.005
Abstract: The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling makes it an attracti...
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Yekaterina Y. Zaytseva,
Joseph D. Valentino,
Pat Gulhati,
B. Mark Evers
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Short survey
(In Press Corrected Proof)
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02 February 2012 |
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c-Met upregulates aquaporin 3 expression in human gastric carcinoma cells via the ERK signalling pathway
DOI: 10.1016/j.canlet.2011.12.040
Abstract: Aquaporin 3 (AQP3) and c-Met are both overexpressed in human gastric carcinoma and highly associated with its metastasis and invasion. However, it still remains unknown whether c-Met and AQP...
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Jianping Wang,
Zhifu Gui,
Longying Deng,
Maocai Sun,
Renhua Guo,
Weiming Zhang,
Lizong Shen
et al.
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Full-length article
(In Press Corrected Proof)
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02 February 2012 |
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Circadian rhythms and tumor growth
DOI: 10.1016/j.canlet.2012.01.001
Abstract: Hormone secretion, metabolism, and the cell cycle are under rhythmic control. Lack of rhythmic control has been predicted to lead to uncontrolled proliferation and cancer. Consistent with th...
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Michael W. Greene
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Short survey
(In Press Corrected Proof)
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01 February 2012 |
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Smac: Its role in apoptosis induction and use in lung cancer diagnosis and treatment
DOI: 10.1016/j.canlet.2011.12.024
Abstract: Apoptosis is a conserved and regulated cell suicide process, the malfunction of which is closely linked with carcinogenesis. Caspases control the induction of apoptosis through an enzymatic ...
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Sida Qin,
Chengcheng Yang,
Shuo Li,
Chongwen Xu,
Yang Zhao,
Hong Ren
et al.
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Short survey
(In Press Corrected Proof)
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30 January 2012 |
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Epigenetic biomarkers in epithelial ovarian cancer
DOI: 10.1016/j.canlet.2011.12.036
Abstract: Ovarian cancer is the most lethal gynecological malignancy and the 5th leading cause of cancer death in women. Women with ovarian cancer are typically diagnosed at late stage, when the cance...
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Brian S. Gloss,
Goli Samimi
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Short survey
(In Press Corrected Proof)
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30 January 2012 |
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Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways
DOI: 10.1016/j.canlet.2011.12.033
Abstract: Obesity is generally acknowledged as a risk factor for endometrial cancer, as accumulated adipocytes partly contribute to the increased production of estrogen which is involved in dysregulat...
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Zhenbo Zhang,
Dongmei Zhou,
Yunli Lai,
Yongjuan Liu,
Xiang Tao,
Qianqian Wang,
Guixu Zhao,
Hongqin Gu,
Hong Liao,
Yaping Zhu,
Xiaowei Xi,
Youji Feng
et al.
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3
DOI: 10.1016/j.canlet.2011.12.034
Abstract: Pyrvinium pamoate (PP), a classical anthelminthic, potently inhibited proliferation and STAT3 Tyr705 phosphorylation of human myeloma (U266B1 and PCM6)/erythroleukemia (HEL 92.1.7) cells. PC...
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Yasuo Harada,
Isao Ishii,
Kiyohiko Hatake,
Tadashi Kasahara
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes
DOI: 10.1016/j.canlet.2011.12.031
Abstract: Circulating tumor cells (CTCs) can be enumerated using CellSearch, but not all breast cancer subtypes, specifically those with epithelial-mesenchymal transition (EMT) characteristics, suffic...
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Bianca Mostert,
Jaco Kraan,
Anieta M. Sieuwerts,
Petra van der Spoel,
Joan Bolt-de Vries,
Wendy J.C. Prager-van der Smissen,
Marcel Smid,
Annemieke M. Timmermans,
John W.M. Martens,
Jan W. Gratama,
John A. Foekens,
Stefan Sleijfer
et al.
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation
DOI: 10.1016/j.canlet.2011.10.038
Abstract: Herein we present a novel molecular mechanism of the antitumor effects of live-attenuated measles virus (MV) vaccine in ovarian cancer. Using a 2-DE/MS-based comparative proteomics strategy,...
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Shengtao Zhou,
Yuhua Li,
Fuqiang Huang,
Boya Zhang,
Tao Yi,
Zhengyu Li,
Hong Luo,
Xiang He,
Qian Zhong,
Ce Bian,
Xiaojuan Lin,
Xiaorong Qi,
Ping Liu,
Canhua Huang,
Xia Zhao,
Yuquan Wei
et al.
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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BH3 profiling – Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions
DOI: 10.1016/j.canlet.2011.12.021
Abstract: Apoptosis is a form of programmed cell death that is controlled at the mitochondrion by the BCL-2 family of proteins. While much has been learned about the structure and function of these pr...
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Victoria Del Gaizo Moore,
Anthony Letai
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Short survey
(In Press Corrected Proof)
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24 January 2012 |
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Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma
DOI: 10.1016/j.canlet.2011.12.007
Abstract: The transient receptor potential TRPM7 ion channel is required for cellular proliferation in pancreatic epithelia and adenocarcinoma. To elucidate the mechanism that mediates the function of...
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Nelson S. Yee,
Weiqiang Zhou,
Minsun Lee,
Rosemary K. Yee
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Epigenetic biomarkers in urological tumors: A systematic review
DOI: 10.1016/j.canlet.2011.12.026
Abstract: Prostate, bladder, kidney and testis cancers, the most common genitourinary (GU) neoplasms, are generally clinically silent at their earliest stages when curative treatment is most likely su...
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Carmen Jerónimo,
Rui Henrique
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Short survey
(In Press Corrected Proof)
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16 January 2012 |
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Cardamonin inhibits osteoclastogenesis induced by tumor cells through interruption of the signaling pathway activated by receptor activator of NF-κB ligand
DOI: 10.1016/j.canlet.2011.12.011
Abstract: Bone loss/resorption or osteoporosis is a disease that is accelerated with aging and age-associated chronic diseases such as cancer. Bone loss has been associated with human multiple myeloma...
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Vivek R. Yadav,
Sahdeo Prasad,
Simone Reuter,
Bokyung Sung,
Norio Yamamoto,
Akira Murakami,
Bharat B. Aggarwal
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research
DOI: 10.1016/j.canlet.2011.12.025
Abstract: Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis for a sensitive assay of DNA damage in human biopsies. The review focuses on the application of γ-H2AX...
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Alesia Ivashkevich,
Christophe E. Redon,
Asako J. Nakamura,
Roger F. Martin,
Olga A. Martin
et al.
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Short survey
(In Press Corrected Proof)
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13 January 2012 |
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Combined treatment of L1CAM antibodies and cytostatic drugs improve the therapeutic response of pancreatic and ovarian carcinoma
DOI: 10.1016/j.canlet.2011.12.035
Abstract: The adhesion molecule L1CAM (CD171) accounts for enhanced motility, invasiveness and chemoresistance of tumor cells and represents a novel marker for various tumor entities including pancrea...
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Heiner Schäfer,
Chantal Dieckmann,
Olena Korniienko,
Gerhard Moldenhauer,
Helena Kiefel,
Alexey Salnikov,
Achim Krüger,
Peter Altevogt,
Susanne Sebens
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes
DOI: 10.1016/j.canlet.2011.08.030
Highlights: ► We describe the characteristics of MSCs from MDS patients (MDS–MSCs) at single cell level. ► MDS–MSCs were similar to normal-MSCs in growth property and differentiation ability. ► MDS–MS...
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Zhi-Gang Zhao,
Wen Xu,
Hai-Peng Yu,
Bing-Ling Fang,
Shu-Hong Wu,
Fang Li,
Wei-Min Li,
Qiu-Bai Li,
Zhi-Chao Chen,
Ping Zou
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
DOI: 10.1016/j.canlet.2011.12.012
Abstract: Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure through direct interactions of radiation with target macromolecules or via products of water rad...
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Edouard I. Azzam,
Jean-Paul Jay-Gerin,
Debkumar Pain
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Short survey
(In Press Corrected Proof)
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11 January 2012 |
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Methyl jasmonate reduces the survival of cervical cancer cells and downregulates HPV E6 and E7, and survivin
DOI: 10.1016/j.canlet.2011.12.028
Abstract: The present study further investigated the mode of action of methyl jasmonate (MJ) in different cervical cancer cell lines. We show that in addition to the short term cytotoxicity, MJ effect...
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Elad Milrot,
Anna Jackman,
Tatiana Kniazhanski,
Pinhas Gonen,
Eliezer Flescher,
Levana Sherman
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Interferon Regulatory Factor 1 (IRF-1) induces p21WAF1/CIP1 dependent cell cycle arrest and p21WAF1/CIP1 independent modulation of survivin in cancer cells
DOI: 10.1016/j.canlet.2011.12.027
Abstract: We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protei...
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Michaele J. Armstrong,
Michael T. Stang,
Ye Liu,
Jinbo Gao,
Baoguo Ren,
Brian S. Zuckerbraun,
Raja S. Mahidhara,
Quanhua Xing,
Eva Pizzoferrato,
John H. Yim
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt–mTOR signaling pathway in oral squamous cell carcinoma
DOI: 10.1016/j.canlet.2011.12.032
Abstract: We investigated the anticancer activity of erufosine in oral squamous carcinoma cell lines in terms of cell proliferation, colony formation, induction of autophagy/apoptosis, cell cycle and ...
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Vaishali Kapoor,
Maya M. Zaharieva,
Satya N. Das,
Martin R. Berger
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO
DOI: 10.1016/j.canlet.2011.12.020
Abstract: Defects in natural killer (NK) cell function are necessary for tumor immune escape, but the underlying regulatory mechanisms in human cancers remain largely unknown. Here we show that fibrob...
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Tuanjie Li,
Yang Yang,
Xuefeng Hua,
Guoying Wang,
Wei Liu,
Changchang Jia,
Yan Tai,
Qi Zhang,
Guihua Chen
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Resistance of leukemic stem-like cells in AML cell line KG1a to natural killer cell-mediated cytotoxicity
DOI: 10.1016/j.canlet.2011.12.017
Abstract: Leukemic stem cells (LSCs) play the central role in the relapse and refractory of acute myeloid leukemia (AML) and highlight the critical need for the new therapeutic strategies to directly ...
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Miaorong She,
Xinqing Niu,
Xilin Chen,
Jinggao Li,
Maohua Zhou,
Yanjie He,
Yi Le,
Kunyuan Guo
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation
DOI: 10.1016/j.canlet.2011.12.030
Abstract: The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the disease resulted from the accumulation of mutations in oncogenes and tumor suppressor genes in c...
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Fabio Coppedè
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Short survey
(In Press Corrected Proof)
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09 January 2012 |
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Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice
DOI: 10.1016/j.canlet.2011.12.022
Abstract: The aromatic amine 4-aminobiphenyl (ABP) is a liver procarcinogen in mice, requiring enzymatic bioactivation to exert its tumorigenic effect. To assess the role of arylamine N-acetyltransfer...
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Kim S. Sugamori,
Debbie Brenneman,
Otto Sanchez,
Mark A. Doll,
David W. Hein,
William M. Pierce,
Denis M. Grant
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells
DOI: 10.1016/j.canlet.2011.11.036
Abstract: Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB ...
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Roser Francisco,
Alba Pérez-Perarnau,
Constanza Cortés,
Joan Gil,
Albert Tauler,
Santiago Ambrosio
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Blockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT
DOI: 10.1016/j.canlet.2011.12.014
Abstract: Blockade of VEGF signaling using RNA interferences, a neutralizing antibody, an antagonizing soluble VEGF receptor, and a receptor tyrosine kinase inhibitor induced anti-tumor effects in hum...
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Jungwhoi Lee,
Taeyun Ku,
Hana Yu,
Kyuha Chong,
Seung-Wook Ryu,
Kyungsun Choi,
Chulhee Choi
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells
DOI: 10.1016/j.canlet.2011.12.015
Abstract: SNX-2112 is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials; however, its mechanism of action needs to be further elaborated. Here we investigated the effec...
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Kai-Sheng Liu,
Hui Liu,
Jin-Huan Qi,
Qiu-Yun Liu,
Zhong Liu,
Min Xia,
Guo-Wen Xing,
Shao-Xiang Wang,
Yi-Fei Wang
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Synergistic interaction between cisplatin and gemcitabine in neuroblastoma cell lines and multicellular tumor spheroids
DOI: 10.1016/j.canlet.2011.12.016
Abstract: The efficacy and mechanism of action of cisplatin and gemcitabine were investigated in a panel of neuroblastoma cell lines and multicellular tumor spheroids. In neuroblastoma spheroids, the ...
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Odette G. Besançon,
Godelieve A.M. Tytgat,
Rutger Meinsma,
René Leen,
Jerry Hoebink,
Ganna V. Kalayda,
Ulrich Jaehde,
Huib N. Caron,
André B.P. van Kuilenburg
et al.
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and β-catenin and enhances invasion in nasopharyngeal carcinoma cells
DOI: 10.1016/j.canlet.2011.12.018
Abstract: Dysregulation of E-cadherin and β-catenin function in cell–cell adhesion is common in nasopharyngeal carcinoma (NPC) and correlates with metastatic disease. In this study, we examined the ro...
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Wai Kien Yip,
Heng Fong Seow
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Full-length article
(In Press Corrected Proof)
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05 January 2012 |
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Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2
DOI: 10.1016/j.canlet.2011.12.023
Abstract: IL-32 is a newly discovered cytokine. Recently, various reports suggest that it plays a role as a proinflammatory mediator and may be involved in several cancer carcinogenesis. However, IL-3...
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Yun Hee Kang,
Mi-Young Park,
Do-Young Yoon,
Seung Ro Han,
Chung Il Lee,
Na Young Ji,
Pyung-Keun Myung,
Hee Gu Lee,
Jae Wha Kim,
Young Il Yeom,
Ye Jin Jang,
Dong Kuk Ahn,
Jong Wan Kim,
Eun Young Song
et al.
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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The Na+/H+ exchanger NHE1, but not the Na+, cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2
DOI: 10.1016/j.canlet.2011.11.023
Abstract: We and others have shown central roles of the Na+/H+ exchanger NHE1 in cell motility. The aim of this study was to determine the roles of NHE1 and of the Na+, cotransporter NBCn1 in motilit...
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Gitte Lauritzen,
Christian-Martin Stock,
Justine Lemaire,
Stine F. Lund,
Mie Frid Jensen,
Britt Damsgaard,
Katrine Seide Petersen,
Maria Wiwel,
Lone Rønnov-Jessen,
Albrecht Schwab,
Stine Falsig Pedersen
et al.
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Full-length article
(In Press Corrected Proof)
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04 January 2012 |
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Kaposi sarcoma-associated herpesvirus (KSHV) induces a functional tumor-associated phenotype for oral fibroblasts
DOI: 10.1016/j.canlet.2011.12.019
Abstract: The Kaposi sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi sarcoma (KS), the most common HIV/AIDS-associated tumor worldwide. Involvement of the oral cavity portends a...
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Lu Dai,
Zhiqiang Qin,
Michael Defee,
Bryan P. Toole,
Keith L. Kirkwood,
Chris Parsons
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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PIG3: A novel link between oxidative stress and DNA damage response in cancer
DOI: 10.1016/j.canlet.2011.12.009
Abstract: Reactive oxygen species (ROS), the most prominent free radicals produced in cells, can have both beneficial and detrimental effects on them. Many genes are known to be involved in ROS regula...
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Athanassios Kotsinas,
Vimla Aggarwal,
E-Jean Tan,
Brynn Levy,
Vassilis G. Gorgoulis
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer
DOI: 10.1016/j.canlet.2011.12.010
Abstract: Purposes: A lot of radiosensitizers have been developed. However, there are few to be available in the clinical setting. Thymidine phosphorylase inhibitor (TPI) regulates the phosphorolysis ...
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Tomohiko Miyatani,
Nobuhiro Kurita,
Tohru Utsunomiya,
Takashi Iwata,
Masanori Nishioka,
Kozo Yoshikawa,
Jun Higashijima,
Hideya Kashihara,
Chie Takasu,
Masakazu Fukushima,
Mitsuo Shimada
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Human recombinant Cripto-1 increases doubling time and reduces proliferation of HeLa cells independent of pro-proliferation pathways
DOI: 10.1016/j.canlet.2011.12.013
Abstract: Human oncofetal protein Cripto-1 (CR-1) is overexpressed in many types of cancers. CR-1 binds to cell surface Glypican-1 to activate Erk1/2 MAPK and Akt pathways leading to cell proliferatio...
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Asim Bikas Das,
Pojul Loying,
Biplab Bose
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway
DOI: 10.1016/j.canlet.2011.11.033
Abstract: Suppression of c-Myc is likely to induce cellular senescence in many tumors with unclear mechanisms. A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) wer...
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Ju Zhang,
Xiaomin Lou,
Shangbin Yang,
Shun He,
Lei Yang,
Mei Liu,
Hongxia Zhu,
Qiang Shan,
Siyuan Su,
Qimin Zhan,
Ningzhi Xu,
Siqi Liu
et al.
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Full-length article
(In Press Corrected Proof)
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30 December 2011 |
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NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop
DOI: 10.1016/j.canlet.2011.12.008
Abstract: Cigarette smoking, either active or passive, is the most important risk factor in the development of human lung cancer. Mounting evidence indicates that cigarette smoke constituents not only...
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Jie Shen,
Lijun Xu,
Taofeek K. Owonikoko,
Shi-Yong Sun,
Fadlo R. Khuri,
Walter J. Curran,
Xingming Deng
et al.
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Full-length article
(In Press Corrected Proof)
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30 December 2011 |
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Survivin isoform Delta Ex3 regulates tumor spheroid formation
DOI: 10.1016/j.canlet.2011.12.002
Abstract: Survivin is an important member of the Inhibitor of Apoptosis Proteins (IAPs) family and has essential roles in apoptosis and cell cycle progression. This gene is commonly upregulated in hum...
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Magali Espinosa,
Gisela Ceballos-Cancino,
Richard Callaghan,
Vilma Maldonado,
Nelly Patiño,
Víctor Ruíz,
Jorge Meléndez-Zajgla
et al.
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Full-length article
(In Press Corrected Proof)
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30 December 2011 |
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Pancreatic cancer: Promise for personalised medicine?
DOI: 10.1016/j.canlet.2011.11.034
Abstract: Pancreatic cancer has an infaust prognosis and is the fourth commonest cause of cancer related death in men. Design of rational treatment has been hampered by lack of insight into the pathog...
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Henri Braat,
Marco Bruno,
Ernst J. Kuipers,
Maikel P. Peppelenbosch
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Short survey
(In Press Corrected Proof)
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30 December 2011 |
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RXRα deletion and E6E7 oncogene expression are sufficient to induce cervical malignant lesions in vivo
DOI: 10.1016/j.canlet.2011.11.031
Abstract: Cervical cancer is the second leading cause of cancer deaths among women worldwide. High-Risk-Human Papillomaviruses (HR-HPVs) play an important etiologic role in the development of carcinom...
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Rodolfo Ocadiz-Delgado,
Eduardo Castañeda-Saucedo,
Arup K. Indra,
Rogelio Hernandez-Pando,
Pedro Flores-Guizar,
Jose Luis Cruz-Colin,
Felix Recillas-Targa,
Guillermo Perez-Ishiwara,
Luis Covarrubias,
Patricio Gariglio
et al.
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Full-length article
(In Press Corrected Proof)
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30 December 2011 |
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Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers
DOI: 10.1016/j.canlet.2011.12.003
Abstract: To identify epigenetic-based biomarkers for diagnosis of ovarian cancer we performed MeDIP-Chip in A2780 and CaOV3 ovarian cancer cell lines. Validation by Sequenom massARRAY methylation ana...
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Brian S. Gloss,
Kate I. Patterson,
Caroline A. Barton,
Maria Gonzalez,
James P. Scurry,
Neville F. Hacker,
Robert L. Sutherland,
Philippa M. O’Brien,
Susan J. Clark
et al.
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Full-length article
(In Press Corrected Proof)
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29 December 2011 |
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Opposite effects of arsenic trioxide on the Nrf2 pathway in oral squamous cell carcinoma in vitro and in vivo
DOI: 10.1016/j.canlet.2011.12.005
Abstract: Nuclear factor erythroid derived 2 like 2 (Nrf2) is a critical transcriptional factor in mediating cellular defense mechanisms against oxidative stress or electrophiles. Arsenic has been rep...
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Xinyan Zhang,
Ying Su,
Min Zhang,
Zheng Sun
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Full-length article
(In Press Corrected Proof)
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29 December 2011 |
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DLK1, delta-like 1 homolog (Drosophila), regulates tumor cell differentiation in vivo
DOI: 10.1016/j.canlet.2011.11.032
Abstract: The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it...
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Asma Begum,
Yuri Kim,
Qun Lin,
Zhong Yun
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Full-length article
(In Press Corrected Proof)
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29 December 2011 |
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New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress
DOI: 10.1016/j.canlet.2011.12.004
Abstract: Reactive oxygen species (ROS) are induced by a variety of endogenous and exogenous sources. At pathologically high levels, ROS cause damage to biological molecules, including DNA. The damage...
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Benjamin P.C. Chen,
Mengxia Li,
Aroumougame Asaithamby
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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Combinational therapy: New hope for pancreatic cancer?
DOI: 10.1016/j.canlet.2011.11.029
Abstract: Pancreatic cancer is a devastating disease with a low overall survival rate. Chemotherapy is the most common treatment for patients presenting with advanced pancreatic cancer. Gemcitabine ac...
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Si Shi,
Wantong Yao,
Jin Xu,
Jiang Long,
Chen Liu,
Xianjun Yu
et al.
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Short survey
(In Press Corrected Proof)
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26 December 2011 |
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B-DIM impairs radiation-induced survival pathways independently of androgen receptor expression and augments radiation efficacy in prostate cancer
DOI: 10.1016/j.canlet.2011.12.006
Abstract: Increased consumption of cruciferous vegetables is associated with decreased risk in prostate cancer (PCa). The active compound in cruciferous vegetables appears to be the self dimerized pro...
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Vinita Singh-Gupta,
Sanjeev Banerjee,
Christopher K. Yunker,
Joseph T. Rakowski,
Michael C. Joiner,
Andre A. Konski,
Fazlul H. Sarkar,
Gilda G. Hillman
et al.
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |
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Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis
DOI: 10.1016/j.canlet.2011.11.035
Abstract: In this report, we investigated the effects of the natural product parthenolide on human B-lymphoma cell lines. We show that parthenolide inhibited NF-κB transcription factor c-Rel (REL). In...
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Alan T. Yeo,
John A. Porco,
Thomas D. Gilmore
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Full-length article
(In Press Corrected Proof)
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26 December 2011 |