Current Issue 1 April 2012, Vol. 317, No. 1

Issue Highlights

Sleeping Beauty – A mouse model for all cancers?
1 April 2012(Vol. 317 | No. 1 | Pages 1-8)
Viive M. Howell

Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A
1 April 2012(Vol. 317 | No. 1 | Pages 9-15)
Chao-Yuan Huang, Chia-Cheng Wei, Kuei-Chiu Chen, Hui-Ju Chen, Ann-Lii Cheng, Kuen-Feng Chen

Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
1 April 2012(Vol. 317 | No. 1 | Pages 16-23)
Anabel José, Luciano Sobrevals, Antoni Ivorra, Cristina Fillat

Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically
06 February 2012
Michal Zapotocky, Ester Mejstrikova, Karel Smetana, Jan Stary, Jan Trka, Julia Starkova
Abstract: Valproic acid (VPA) has extensive effects on leukemic blasts through its inhibition of histone deacetylases. The main goal of this study was to identify the subgroup of patients who may bene...
Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition
06 February 2012
Siker Kimbung, Ewa Biskup, Ida Johansson, Kristina Aaltonen, Astrid Ottosson-Wadlund, Sofia Gruvberger-Saal, Heather Cunliffe, Bengt Fadeel, Niklas Loman, Pontus Berglund, Ingrid Hedenfalk
Abstract: Although pre-clinical and clinical studies on PARP1 inhibitors, alone and in combination with DNA-damaging agents, show promising results, further ways to improve and broaden the scope of ap...
A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth
06 February 2012
Gene L. Bidwell, Eddie Perkins, Drazen Raucher
Abstract: Although surgical resection with adjuvant chemotherapy and/or radiotherapy are used to treat breast tumors, normal tissue tolerance, development of metastases, and inherent tumor resistance ...
Chmp1A acts as a tumor suppressor gene that inhibits proliferation of renal cell carcinoma
06 February 2012
Zhenqiang You, Yanfei Xin, Yan Liu, Junying Sun, Guoliang Zhou, Haiyan Gao, Pansheng Xu, Yunxiang Chen, Guochan Chen, Lijiang Zhang, Liqiang Gu, Zhiqin Chen, Bin Han, Yaoxian Xuan
Abstract: Renal cell carcinoma (RCC) is a highly malignant and often fatal disease of the kidney. Chmp1A is a member of the Endosomal Sorting Complex Required for Transport (ESCRT-III) family, and pla...
Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling
03 February 2012
Shun Fujimaki, Yasunobu Matsuda, Toshifumi Wakai, Ayumi Sanpei, Masayuki Kubota, Masaaki Takamura, Satoshi Yamagiwa, Masahiko Yano, Shogo Ohkoshi, Yutaka Aoyagi
Abstract: Sorafenib is a multi-kinase inhibitor applicable to hepatocellular carcinoma (HCC), but its limited therapeutic effects are a major problem to be solved. Here, we show that blockade of ataxi...

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Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST)
15 December 2011 (Vol. 312 | No. 1 | Pages 43-54)
Marc Daniels, Irene Lurkin, Roland Pauli, Erhard Erbstößer, Uwe Hildebrandt, Karsten Hellwig, Uwe Zschille, Petra Lüders, Gabriele Krüger, Jürgen Knolle, Bernd Stengel, Friedrich Prall, Kay Hertel, Hartmut Lobeck, Brigitte Popp, Franz Theissig, Peter Wünsch, Ellen Zwarthoff, Abbas Agaimy, Regine Schneider-Stock
PCA3: From basic molecular science to the clinical lab
1 February 2011 (Vol. 301 | No. 1 | Pages 1-6)
John R. Day, Matthias Jost, Mark A. Reynolds, Jack Groskopf, Harry Rittenhouse
Chemotherapy-induced neutropenia in lung cancer patients: The role of antibiotic prophylaxis
26 December 2011 (Vol. 313 | No. 1 | Pages 9-14)
Vasileios Kouranos, George Dimopoulos, Antonios Vassias, Kostas N. Syrigos
Combined targeting of the VEGFr/EGFr and the mammalian target of rapamycin (mTOR) signaling pathway delays cell cycle progression and alters adhesion behavior of prostate carcinoma cells
1 February 2011 (Vol. 301 | No. 1 | Pages 17-28)
Steffen Wedel, Lukasz Hudak, Jens-Michael Seibel, Eva Juengel, Igor Tsaur, Axel Haferkamp, Roman A. Blaheta
Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells
1 February 2011 (Vol. 301 | No. 1 | Pages 106-118)
Pamela Ehrenfeld, Ivan Conejeros, Maria F. Pavicic, Carola E. Matus, Carlos B. Gonzalez, Andrew F.G. Quest, Kanti D. Bhoola, Maria T. Poblete, Rafael A. Burgos, Carlos D. Figueroa

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About Cancer Letters

Cancer Letters is an international journal that considers full-length articles and Mini Reviews in the broad area of basic and translational oncology. Additionally, Special Issues highlight topical areas in cancer research. Basic areas of interest to a broad readership of Cancer Letters include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal places emphasis on experimental therapeutics, particularly targeted therapies for personalized cancer medicine.