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Editorial Board
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| Mini-review |
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Sleeping Beauty – A mouse model for all cancers?
09 December 2011
Abstract: Sleeping Beauty (SB) is a genetically engineered insertional mutagenesis system. Its ability to rapidly induce cancer in SB-transgenic mice as well as the ease of identification of the mutat...
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Viive M. Howell
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1-8
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| Regular Articles |
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Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A
02 December 2011
Abstract: Previously, we demonstrated that cancerous inhibitor of protein phosphatase 2A (CIP2A) mediates bortezomib-induced apoptosis in hepatocellular carcinoma cells. Herein, we report that bortezo...
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Chao-Yuan Huang,
Chia-Cheng Wei,
Kuei-Chiu Chen,
Hui-Ju Chen,
Ann-Lii Cheng,
Kuen-Feng Chen
et al.
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9-15
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Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
30 November 2011
Abstract: Pancreatic ductal adenocarcinoma (PDAC) therapies show limited success. Irreversible electroporation (IRE) is an innovative loco-regional therapy in which high-voltage pulses are applied to ...
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Anabel José,
Luciano Sobrevals,
Antoni Ivorra,
Cristina Fillat
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16-23
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LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells
02 December 2011
Abstract: P21-activated kinase 4 (PAK4), a serine/threonine protein kinase, has involved in the regulation of cytoskeletal reorganization, cell proliferation, gene transcription, oncogenic transformat...
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Jian Zhang,
Jian Wang,
Qiqiang Guo,
Yu Wang,
Ying Zhou,
Huizhi Peng,
Maosheng Cheng,
Dongmei Zhao,
Feng Li
et al.
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24-32
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Overexpression of BMI1 confers clonal cells resistance to apoptosis and contributes to adverse prognosis in myelodysplastic syndrome
12 December 2011
Abstract: The polycomb group (PcG) protein BMI1 plays a critical role in regulating self renewal capacity of both normal and leukemic stem cells. BMI1 is frequently overexpressed in several types of c...
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Feng Xu,
Rui Yang,
Lingyun Wu,
Qi He,
Zheng Zhang,
Qingxia Zhang,
Yujuan Yang,
Juan Guo,
Chunkang Chang,
Xiao Li
et al.
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33-40
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Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells
02 December 2011
Abstract: Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level o...
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Lujia Gribben,
Robert C. Baxter,
Deborah J. Marsh
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41-48
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Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): Timing of maternal exposures determines target tissue response in offspring
02 December 2011
Abstract: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC...
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Lyndsey E. Shorey,
David J. Castro,
William M. Baird,
Lisbeth K. Siddens,
Christiane V. Löhr,
Melissa M. Matzke,
Katrina M. Waters,
Richard A. Corley,
David E. Williams
et al.
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49-55
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Newcastle disease virus induces apoptosis in cisplatin-resistant human lung adenocarcinoma A549 cells in vitro and in vivo
02 December 2011
Abstract: Cisplatin (DDP) is widely used in lung cancer chemotherapy. However, cisplatin resistance represents a major obstacle in effective clinical treatment. This study aims to investigate whether ...
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Songshu Meng,
Zhizhi Zhou,
Fei Chen,
Xiangang Kong,
Huairan Liu,
Ke Jiang,
Wenbo Liu,
Maozhi Hu,
Xiaorong Zhang,
Chan Ding,
Yantao Wu
et al.
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56-64
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P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth
30 November 2011
Abstract: The p21-activated kinase 1 (PAK1) plays important roles in cell growth, motility, and transformation. The aims of this study were to delineate the signalling mechanisms downstream of PAK1, a...
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Hong He,
Nhi Huynh,
Kevin H. Liu,
Cathy Malcontenti-Wilson,
Jin Zhu,
Christopher Christophi,
Arthur Shulkes,
Graham S. Baldwin
et al.
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65-71
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Copy number status and mutation analyses of anaplastic lymphoma kinase (ALK) gene in 90 sporadic neuroblastoma tumors
09 December 2011
Abstract: Somatic and germline mutations of the anaplastic lymphoma kinase (ALK) gene were recently described in neuroblastoma (NB). In this study, we investigated the association of ALK copy number a...
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Ozkan Bagci,
Sait Tumer,
Nur Olgun,
Oguz Altungoz
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72-77
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Identification of heat shock protein 90 inhibitors to sensitize drug resistant side population tumor cells using a cell based assay platform
21 December 2011
Abstract: Current cancer therapeutics are identified based on initial tumor regression screens that mostly kill differentiated tumor cells, sparing the rare cancer stem cells (CSCs). Being rare and di...
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Praveen K. Sobhan,
Mahendra Seervi,
Jeena Joseph,
Bhavya Balan Chandrika,
Saneesh Varghese,
T.R. Santhoshkumar,
M. Radhakrishna Pillai
et al.
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78-88
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Targeting cathepsin S induces tumor cell autophagy via the EGFR–ERK signaling pathway
06 December 2011
Abstract: Cathepsin S is a cellular cysteine protease, which is frequently over-expressed in human cancer cells and plays important role in tumor metastasis. However, the role of cathepsin S in regula...
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Kuo-Li Chen,
Wun-Shaing Wayne Chang,
Chun Hei Antonio Cheung,
Chun-Cheng Lin,
Chien-Chang Huang,
Yung-Ning Yang,
Chang-Po Kuo,
Ching-Chuan Kuo,
Yi-Hsun Chang,
Ko-Jiunn Liu,
Ching-Ming Wu,
Jang-Yang Chang
et al.
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89-98
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Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: A potential mechanism of immune escape
29 December 2011
Abstract: B7-homolog 4 (B7-H4), a recently identified homolog of B7.1/2 (CD80/86), has been described to exert co-stimulatory and immune regulatory functions. We investigated the expression and the fu...
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Cheng Chen,
Qiu-Xia Qu,
Yu Shen,
Chuan-Yong Mu,
Yi-Bei Zhu,
Xue-Guang Zhang,
Jian-An Huang
et al.
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99-105
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p65-Dependent production of interleukin-1β by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts
06 December 2011
Abstract: Skeletal metastases are a frequent complication of prostate, breast and lung cancer, and the interactions of tumor cells with bone-forming osteoblasts and bone-resorbing osteoclasts have bee...
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Jochen Schulze,
Kristoffer Weber,
Anke Baranowsky,
Thomas Streichert,
Tobias Lange,
Alexander Simon Spiro,
Joachim Albers,
Sebastian Seitz,
Josef Zustin,
Michael Amling,
Boris Fehse,
Thorsten Schinke
et al.
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106-113
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