Cancer Letters
Volume 125, Issue 1 , Pages 25-30, 13 March 1998

Epstein–Barr virus infection and response to radiotherapy in squamous cell carcinoma of the oral cavity

Department of Oral and Maxillofacial Radiology, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita-city, Osaka 565, Japan

Received 17 September 1997; accepted 27 October 1997.

Abstract 

We have retrospectively investigated the presence of Epstein–Barr virus (EBV) DNA in 45 cases of squamous cell carcinomas (SCCs) of the oral cavity using polymerase chain reaction (PCR). We analyzed the association between EBV infection and the clinicopathological characteristics, tumor response to radiotherapy, or prognosis to determine the clinical significance of EBV. EBV DNA was detected in 29 cases (64.4%) of SCCs. No significant differences were observed between the presence or absence of EBV. Our results indicate that EBV infection is not related to tumor response to radiotherapy, or the prognosis of the patients.

Keywords:  Epstein–Barr virus, Oral squamous cell carcinoma, Radiotherapy, Prognosis

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0304-3835(97)00485-0

Cancer Letters
Volume 125, Issue 1 , Pages 25-30, 13 March 1998

Article Tools

* Image Usage & Resolution