Cancer Letters

Cancer Letters

Volume 426, 10 July 2018, Pages 1-3
Cancer Letters

Perspective
Perspectives on the physiological roles of microRNAs in immune-metabolism: Where are we now?

https://doi.org/10.1016/j.canlet.2018.03.047Get rights and content

Highlights

  • Experiments in KO mouse models will strengthen our understanding of the physiological and pathological roles played by miRNAs and/or miRNA families within the context of immune-metabolism.

  • It will be important to explore additional miRNAs that have the capacity to regulate various aspects of metabolism in immune cells.

  • The knowledge acquired from engineered mouse models may pave the way for preclinical studies.

Section snippets

Main text

To coordinate the dynamic functional regulation needed to maintain tissue homeostasis, the immune system requires precise control of cellular metabolic pathways [1,2]. Different activation statuses are associated with varying metabolic demands [3,4]. For example, while naive lymphocytes are relatively quiescent cells that require minimal cellular biosynthesis, activated lymphocytes are highly metabolically active, facilitating cellular proliferation and utilizing more energy for greater

Conflicts of interest

The author declares that there is no conflict of interest.

Acknowledgements

The author sincerely apologizes to those whose work was not cited due to time and space constraints.

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