Cancer Letters
Volume 319, Issue 2 , Pages 232-241, 28 June 2012

Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition

  • Siker Kimbung

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • ,
  • Ewa Biskup

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    • ,
  • Ida Johansson

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • ,
  • Kristina Aaltonen

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • ,
  • Astrid Ottosson-Wadlund

      Affiliations

    • Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Sofia Gruvberger-Saal

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • ,
  • Heather Cunliffe

      Affiliations

    • Translational Genomics Research Institute, Phoenix, AZ, United States
    • ,
  • Bengt Fadeel

      Affiliations

    • Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    • ,
  • Niklas Loman

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • ,
  • Pontus Berglund

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • ,
  • Ingrid Hedenfalk

      Affiliations

    • Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    • CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden
    • Corresponding Author InformationCorresponding author at: Department of Oncology, Clinical Sciences, Lund University, BMC C13, SE-22184 Lund, Sweden. Tel.: +46 46 2220652; fax: +46 46 147327.

Received 14 July 2011; received in revised form 30 December 2011; accepted 11 January 2012. published online 06 February 2012.

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PII: S0304-3835(12)00045-6

doi:10.1016/j.canlet.2012.01.015

Cancer Letters
Volume 319, Issue 2 , Pages 232-241, 28 June 2012

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