Cancer Letters
Volume 316, Issue 2 , Pages 126-131, 28 March 2012

Intussusceptive microvascular growth in tumors

  • Domenico Ribatti

      Affiliations

    • Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy
    • Corresponding Author InformationCorresponding author. Address: Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11, Policlinico, 70124 Bari, Italy. Tel.: +39 080 5478326; fax: +39 080 5478310.
    • ,
  • Valentin Djonov

      Affiliations

    • Institute of Anatomy, University of Berne Medical School, Berne, Switzerland

Received 19 September 2011; received in revised form 26 October 2011; accepted 28 October 2011. published online 26 December 2011.

Abstract 

Intussusception is an alternative to the sprouting mode of angiogenesis. The advantage of this mechanism of vascular growth is that blood vessels are generated more rapidly and the capillaries thereby formed are less leaky. This review article summarizes our current knowledge concerning the role played by intussusceptive microvascular growth in tumor growth. Interestingly, an angiogenic switch from sprouting to intussusceptive angiogenesis occurs after treatment with angiogenesis inhibitors and may be considered as a tumor-protective adaptative response.

Keywords: Angiogenesis, Erythropoietin, Intussusceptive microvascular growth, Tumor growth, Vascular endothelial growth factor

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PII: S0304-3835(11)00657-4

doi:10.1016/j.canlet.2011.10.040

Cancer Letters
Volume 316, Issue 2 , Pages 126-131, 28 March 2012

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