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Cancer Letters
Volume 316, Issue 2
, Pages 113-125
, 28 March 2012
SUMOylation in carcinogenesis
References
- . A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J. Biol. Chem. 2000;275:14102–14106
- . Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J. Biol. Chem. 2001;276:35368–35374
- . SUMO Regulation of Cellular Processes. Springer; 2009;
- . Structure determination of the small ubiquitin-related modifier SUMO-1. J. Mol. Biol. 1998;280:275–286
- . Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell. 2002;108:345–356
- . Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast. Mol. Cell. 2000;5:865–876
- . Concepts in sumoylation: a decade on. Nat. Rev. Mol. Cell. Biol. 2007;8:947–956
- . A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell. 1997;88:97–107
- . A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell Biol. 1996;135:1457–1470
- . SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?. Genes Dev. 2004;18:2046–2059
- . Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity. Curr. Opin. Genet. Dev. 2003;13:108–113
- . Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. J. Biol. Chem. 2001;276:18513–18518
- . Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. J. Biol. Chem. 2001;276:40263–40267
- . Sumoylation dynamics during keratinocyte differentiation. J. Cell Sci. 2007;120:125–136
- . SUMO changes Sox for developmental diversity. Mol. Cell. 2005;20:495–496
- . Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth. J. Biol. Chem. 2007;282:16465–16475
- . SUMO1 haploinsufficiency leads to cleft lip and palate. Science. 2006;313:1751
- . A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J. 1998;17:3052–3065
- . RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. Mol. Biol. Cell. 2009;20:410–418
- . Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression. Biochem. Biophys. Res. Commun. 2009;382:215–218
- . A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. J. Biol. Chem. 2004;279:27233–27238
- . A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat. Genet. 2004;36:837–841
- . Protein modification by SUMO. Annu. Rev. Biochem. 2004;73:355–382
- . Ubch9 conjugates SUMO but not ubiquitin. FEBS Lett. 1997;417:297–300
- . Ubc9 is essential for viability of higher eukaryotic cells. Exp. Cell Res. 2002;280:212–221
- . Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J. Biol. Chem. 1997;272:26799–26802
- . SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell. 2001;107:5–8
- . SAP – a putative DNA-binding motif involved in chromosomal organization. Trends Biochem. Sci. 2000;25:112–114
- . SAF-Box, a conserved protein domain that specifically recognizes scaffold attachment region DNA. Mol. Cell. Biol. 2000;20:7480–7489
- . PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 2001;15:3088–3103
- . PIAS proteins and transcriptional regulation – more than just SUMO E3 ligases?. Genes Dev. 2006;20:754–758
- . Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators. J. Biol. Chem. 2002;277:16993–17001
- . Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol. Cell. 2001;8:713–718
- . PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol. Cell. Biol. 2002;22:5222–5234
- . PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1. FEBS Lett. 2002;530:204–208
- . PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J. Biol. Chem. 2002;277:41311–41317
- . Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO J. 2002;21:5206–5215
- . Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc Natl Acad Sci U S A. 2002;99:2872–2877
- . The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. Nat. Rev. Mol. Cell. Biol. 2010;11:861–871
- . Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. J. Biol. Chem. 2002;277:50131–50136
- . An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell. 2001;106:735–744
- . A novel factor required for the SUMO1/Smt3 conjugation of yeast septins. Gene. 2001;275:223–231
- . Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. Mol. Cell. 2009;35:669–682
- . SUMO junction-what’s your function? New insights through SUMO-interacting motifs. EMBO Rep. 2007;8:550–555
- . A SIM-ultaneous role for SUMO and ubiquitin. Trends Biochem. Sci. 2008;33:201–208
- . Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J. 2005;24:439–451
- . Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 2010;463:906–912
- . Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol. Cell. Biol. 2005;25:2273–2287
- . Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol. 2003;23:2953–2968
- . PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci U S A. 2006;103:45–50
- . The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell. 2002;108:109–120
- . The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J. 2002;21:2682–2691
- . Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat. Struct. Mol. Biol. 2005;12:67–74
- . Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell. 2008;133:103–115
- . Linking the Rb and polycomb pathways. Mol. Cell. 2001;8:557–569
- . A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science. 2002;296:1132–1136
- . The polycomb protein Pc2 is a SUMO E3. Cell. 2003;113:127–137
- . Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell. 2002;111:185–196
- . Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002;16:2893–2905
- . Multiple activities contribute to Pc2 E3 function. EMBO J. 2005;24:108–119
- . SUMOylation and De-SUMOylation: wrestling with life’s processes. J. Biol. Chem. 2009;284:8223–8227
- . A new protease required for cell-cycle progression in yeast. Nature. 1999;398:246–251
- . The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol. Cell. Biol. 2000;20:2367–2377
- . Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. J. Biochem. 2000;128:723–725
- . Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins. Nat. Cell. Biol. 2003;5:21–27
- . SUMO conjugation and deconjugation. Mol. Gen. Genet. 2000;263:771–786
- . Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics. 2001;158:95–107
- . The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J. Cell. Biol. 2003;160:1069–1081
- . SUMOylation and deSUMOylation at a glance. J. Cell Sci. 2009;122:4249–4252
- . Mechanisms, regulation and consequences of protein SUMOylation. Biochem. J. 2010;428:133–145
- . The SUMO-specific protease SENP5 is required for cell division. Mol. Cell. Biol. 2006;26:4489–4498
- . Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J. Biol. Chem. 2006;281:15869–15877
- . Association of the human SUMO-1 protease SENP2 with the nuclear pore. J. Biol. Chem. 2002;277:19961–19966
- . Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol. Cell. Biol. 2002;22:6498–6508
- . A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase. Eur. J. Biochem. 2000;267:6423–6427
- . The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J. Cell Sci. 2007;120:1178–1188
- . Differential regulation of sentrinized proteins by a novel sentrin-specific protease. J. Biol. Chem. 2000;275:3355–3359
- . Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. J. Biol. Chem. 2004;279:692–703
- . Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. FEBS Lett. 2005;579:6272–6278
- . SUMO: ligases, isopeptidases and nuclear pores. Trends Biochem. Sci. 2003;28:612–618
- K.O. Alegre, and D. Reverter, Swapping the SUMO isoform specificity of SUMO proteases SENP6 and SENP7, J. Biol. Chem. (2011).
- . Emerging roles of desumoylating enzymes. Biochim. Biophys. Acta. 2009;1792:155–162
- . The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing. Biochem. J. 2006;397:279–288
- . Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1. Biochem. J. 2005;386:325–330
- . The Ran GTPase regulates kinetochore function. Dev. Cell. 2003;5:99–111
- . The small GTPase Ran: interpreting the signs. Curr. Opin. Cell. Biol. 2003;15:338–344
- . RanGTP mediates nuclear pore complex assembly. Nature. 2003;424:689–694
- . The mechanisms of PML-nuclear body formation. Mol. Cell. 2006;24:331–339
- . SUMO-1 protease-1 regulates gene transcription through PML. Mol. Cell. 2002;10:843–855
- . SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J. Biol. Chem. 2010;285:12906–12915
- . The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Mol. Biol. Cell. 2011;22:78–90
- . SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J. Cell Biol. 2006;174:939–949
- . The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. Biochem. Biophys. Res. Commun. 2008;371:823–828
- . Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem. J. 2009;421:223–230
- . SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol. Cell. Biol. 2004;24:6021–6028
- . Molecular biology of the androgen receptor. J. Clin. Oncol. 2002;20:3001–3015
- . Combinatorial control of gene expression by nuclear receptors and coregulators. Cell. 2002;108:465–474
- . Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. J. Biol. Chem. 2007;282:37341–37349
- . Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Proc Natl Acad Sci USA. 2000;97:14145–14150
- . Role of desumoylation in the development of prostate cancer. Neoplasia. 2006;8:667–676
- . SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell. Death Differ. 2008;15:739–750
- . SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007;131:584–595
- . Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Mol. Cell. Biol. 2002;22:3803–3819
- . Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. J. Biol. Chem. 2001;276:39060–39066
- . Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J. Biol. Chem. 2006;281:30669–30677
- . Role of ubiquitination in IGF-1 receptor signaling and degradation. PLoS One. 2007;2:e340
- . The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nat. Cell. Biol. 2008;10:654–664
- . The multifaceted proteins Reptin and Pontin as major players in cancer. Biochim. Biophys. Acta. 2011;1815:147–157
- . SUMOylation modulates the function of Aurora-B kinase. J. Cell Sci. 2010;123:2823–2833
- . Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature. 2009;462:935–939
- . Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis. Nat. Cell. Biol. 2006;8:631–639
- . And H. de The, Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat. Cell. Biol. 2008;10:547–555
- . SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy. Nucl. Acids Res. 2008;36:263–283
- . PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes. J. Biol. Chem. 2010;285:14415–14423
- . SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor. Sci. Signal. 2010;3:ra10
- . Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity. Mol. Endocrinol. 2005;19:2671–2684
- . SUMO-1 modification of the Wilms’ tumor suppressor WT1. Cancer Res. 2004;64:7846–7851
- . Regulation of p53 family members by the ubiquitin-like SUMO system. DNA Repair (Amst). 2009;8:491–498
- . Cell cycle-dependent conjugation of endogenous BRCA1 protein with SUMO-2/3. Biochim. Biophys. Acta. 2011;1810:432–438
- X. Xu, J. Vatsyayan, C. Gao, C.J. Bakkenist, and J. Hu, Sumoylation of eIF4E activates mRNA translation, EMBO Rep 11, 299–304.
- . Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 2011;30:2207–2218
- . Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science. 2010;328:240–243
- . Sumoylation and its contribution to cancer. In: Wilson VG editors. SUMO Regulation of Cellular Processes. Springer; 2009;p. 253–272
- . Post-translational modifications of steroid receptors. Biomed. Pharmacother. 2006;60:520–528
- . SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4. Mol. Cell. Biol. 2005;25:3506–3518
- . SUMO and NF-kappaB ties. Cell. Mol. Life Sci. 2007;64:1979–1996
- . Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. EMBO J. 2003;22:2047–2059
- . Trinucleotide repeat disorders. Annu. Rev. Neurosci. 2007;30:575–621
- . Huntington’s disease. Lancet. 2007;369:218–228
- . SUMO modification of Huntingtin and Huntington’s disease pathology. Science. 2004;304:100–104
- . Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science. 2009;324:1327–1330
- . Phosphorylation of tau by fyn: implications for Alzheimer’s disease. J. Neurosci. 2004;24:2304–2312
- . Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. J. Biol. Chem. 2006;281:9919–9924
- . Alzheimer’s disease. Lancet. 2006;368:387–403
- . A century of Alzheimer’s disease. Science. 2006;314:777–781
- . Intracellular amyloid-beta in Alzheimer’s disease. Nat. Rev. Neurosci. 2007;8:499–509
- . Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels. Biochem. Biophys. Res. Commun. 2008;374:673–678
- . Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. Biochem. J. 2007;404:309–316
- . Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003;100:259–264
- . alpha-Synuclein locus triplication causes Parkinson’s disease. Science. 2003;302:841
- . DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease. Neurology. 2004;62:389–394
- . Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell. Death Differ. 2006;13:96–108
- . DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. 2001;276:37556–37563
- . DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J. Biol. Chem. 2006;281:20940–20948
- . Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation. Hum. Mol. Genet. 2008;17:3357–3367
- . SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal. J. Biol. Chem. 2005;280:21942–21948
- . Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: implication of JNK pathway. Biochem. Biophys. Res. Commun. 2010;393:280–285
- . SUMO-1 modification increases human SOD1 stability and aggregation. Biochem. Biophys. Res. Commun. 2006;347:406–412
- . Nuclear lamins: laminopathies and their role in premature ageing. Physiol. Rev. 2006;86:967–1008
- . Human laminopathies: nuclei gone genetically awry. Nat. Rev. Genet. 2006;7:940–952
- . Nuclear lamins, diseases and aging. Curr. Opin. Cell. Biol. 2006;18:335–341
- . Laminopathies: multiple disorders arising from defects in nuclear architecture. J. Biosci. 2006;31:405–421
- . Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J. Cell Biol. 2008;182:35–39
- . Mapping genes for autoimmunity in humans: type 1 diabetes as a model. Immunol. Rev. 2002;190:182–194
- . A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem. Biophys. Res. Commun. 2005;337:517–520
- . Sumo-1 function is dispensable in normal mouse development. Mol. Cell. Biol. 2008;28:5381–5390
- . SUMO boosts the DNA damage response barrier against cancer. Cancer Cell. 2010;17:9–11
- . Principles of ubiquitin and SUMO modifications in DNA repair. Nature. 2009;458:461–467
- . Regulation of DNA repair throughout the cell cycle. Nat. Rev. Mol. Cell. Biol. 2008;9:297–308
- . Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade. Int. J. Cancer. 2009;125:596–602
- . Efficacy of DNA double-strand breaks repair in breast cancer is decreased in carriers of the variant allele of the UBC9 gene c.73G>A polymorphism. Mutat. Res. 2010;694:31–38
- . The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature. 2009;462:886–890
- . P53 at a glance. J. Cell Sci. 2010;123:2527–2532
- . Post-translational modification of p53 in tumorigenesis. Nat. Rev. Cancer. 2004;4:793–805
- . Massively regulated genes: the example of TP53. J. Pathol. 2010;220:164–173
- . Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harbor Perspect. Biol. 2009;1:1–16
- . The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress. Mol. Cell. Biol. 2000;20:2023–2030
- . Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. EMBO J. 1999;18:6462–6471
- . SUMO-1 modification activates the transcriptional response of p53. EMBO J. 1999;18:6455–6461
- . C-Jun and p53 activity is modulated by SUMO-1 modification. J. Biol. Chem. 2000;275:13321–13329
- . Functional analysis and intracellular localization of p53 modified by SUMO-1. Oncogene. 2001;20:2587–2599
- . Live or let die: the cell’s response to p53. Nat. Rev. Cancer. 2002;2:594–604
- . MDM2-ARF complex regulates p53 sumoylation. Oncogene. 2003;22:5348–5357
- . P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2. FEBS Lett. 2002;528:207–211
- . SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination. Nat. Cell Biol. 2006;8:1424–1431
- . SUMO and its role in human diseases. Int. Rev. Cell. Mol. Biol. 2011;288:167–183
- . Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol. Cell. Biol. 2005;25:6964–6979
- . Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases. J. Biol. Chem. 2005;280:14492–14498
- . A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009;16:295–308
- . NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005;5:749–759
- . SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol. Cell. 1998;2:233–239
- . TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell. 2010;17:481–496
- . A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol. Cell. Biol. 2011;31:2774–2786
- . Hallmarks of cancer: the next generation. Cell. 2011;144:646–674
- . Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell. 2003;115:565–576
- . Targeting Ubc9 for cancer therapy. Expert. Opin. Ther. Targets. 2005;9:1203–1216
- . A role for Ubc9 in tumorigenesis. Oncogene. 2005;24:2677–2683
- . Differential gene expression in human lung adenocarinomas and squamous cell carcinomas. Clin. Cancer Res. 2002;8:1127–1138
- . Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. J. Clin. Endocrinol. Metab. 2005;90:2314–2320
- . SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors. Cancer Lett. 2011;309:78–84
- . The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome. Blood. 2010;115:2827–2834
- . Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 2006;5:769–784
- . Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. J. Antibiot. (Tokyo). 2000;53:1191–1200
- . Histone deacetylation in epigenetics: an attractive target for anticancer therapy. Med. Res. Rev. 2005;25:261–309
- . Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer. Cancer Res. 2006;66:11298–11304
- . Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589. Clin. Cancer Res. 2006;12:634–642
- . HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention. Oncogene. 2007;26:5310–5318
- . Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 2002;277:25748–25755
- . SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J. Biol. Chem. 2005;280:10264–10276
- . P300 transcriptional repression is mediated by SUMO modification. Mol. Cell. 2003;11:1043–1054
- . SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. Oncogene. 2007;26:5866–5876
- . SUMO promotes HDAC-mediated transcriptional repression. Mol. Cell. 2004;13:611–617
- . PIASx acts as an Elk-1 coactivator by facilitating derepression. EMBO J. 2005;24:2161–2171
- . Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol. Cell. Biol. 2005;25:8456–8464
- . Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J. 2009;28:1246–1259
- . Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation. Mol. Cell. Biol. 2008;28:5658–5667
- . Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucl. Acids Res. 2004;32:598–610
- . Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification. FEBS Lett. 2008;582:3723–3728
- . PIASy-mediated repression of the androgen receptor is independent of sumoylation. Oncogene. 2004;23:3059–3066
- . SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc Natl Acad Sci U S A. 2005;102:16973–16978
- . Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta. Proc Natl Acad Sci U S A. 2002;99:12807–12812
- . Targeting the ubiquitin system in cancer therapy. Nature. 2009;458:438–444
- . RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat. Cell. Biol. 2008;10:538–546
- . A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processing. Anal. Biochem. 2007;363:83–90
- . SUMO is growing senescent. Cell Cycle. 2007;6:677–681
- . Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Trends Biochem. Sci. 2006;31:324–332
- . Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Proc Natl Acad Sci U S A. 2007;104:5073–5078
- . SUMO-1 and p53. Cell Cycle. 2002;1:245–249
- . Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. J. Biol. Chem. 2002;277:30798–30804
- . Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 1991;5:670–682
- . Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity. J. Biol. Chem. 2002;277:8999–9009
- . Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A. 2003;100:986–991
- . SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. J. Biol. Chem. 2005;280:24330–24338
- . Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation. Oncogene. 2007;26:395–406
- . Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy. Circ. Res. 2003;92:1201–1208
- . Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation. Am. J. Physiol. Endocrinol. Metab. 2003;284:E830–E840
- . SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol. Cell. 2002;10:831–842
- . PIAS proteins promote SUMO-1 conjugation to STAT1. Blood. 2003;102:3311–3313
- . Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. Proc Natl Acad Sci U S A. 1999;96:7467–7472
- . Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies. Proc Natl Acad Sci U S A. 2000;97:13281–13285
- . Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells. J. Mol. Endocrinol. 2004;32:595–613
- . Sumoylation of eIF4E activates mRNA translation. EMBO Rep. 2010;11:299–304
- . The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol. Cell. 2006;22:783–794
- . SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J. Biol. Chem. 2002;277:23658–23663
- . Sumoylation of ING2 regulates the transcription mediated by Sin3A. Oncogene. 2010;29:5946–5956
- . SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells. Proc Natl Acad Sci U S A. 2007;104:20793–20798
- . Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells. Cancer Sci. 2011;102:1582–1589
- . Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues. Hum. Pathol. 2010;41:1286–1298
PII: S0304-3835(11)00653-7
doi: 10.1016/j.canlet.2011.10.036
© 2011 Elsevier Ireland Ltd. All rights reserved.
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Cancer Letters
Volume 316, Issue 2
, Pages 113-125
, 28 March 2012
