MicroRNA expression and its implication for the diagnosis and therapeutic strategies of gastric cancer

Wang, Jianbo; Wang, Qingwei; Liu, Hong; Hu, Bo; Zhou, Wei; Cheng, Yufeng

doi:10.1016/j.canlet.2010.07.018

Next »Cancer Letters
Volume 297, Issue 2 , Pages 137-143, 28 November 2010

MicroRNA expression and its implication for the diagnosis and therapeutic strategies of gastric cancer

Jianbo Wang
- Department of Radiation Oncology, Qilu Hospital of Shandong University, West Wenhua Rd. 107, 250012 Jinan, China
- These two authors contributed equally to this work.
Qingwei Wang
- Department of Radiation Oncology, Qilu Hospital of Shandong University, West Wenhua Rd. 107, 250012 Jinan, China
- These two authors contributed equally to this work.
Hong Liu
- Department of Radiation Oncology, Qilu Hospital of Shandong University, West Wenhua Rd. 107, 250012 Jinan, China
Bo Hu
- Department of Surgery, Shandong Provincial Hospital, Jingwu Rd. 324, 250021 Jinan, China
Wei Zhou
- Department of Radiation Oncology, Qilu Hospital of Shandong University, West Wenhua Rd. 107, 250012 Jinan, China
Yufeng Cheng
- Department of Radiation Oncology, Qilu Hospital of Shandong University, West Wenhua Rd. 107, 250012 Jinan, China
- Corresponding author. Tel.: +86 531 82169831; fax: +86 531 86927544.

Received 17 May 2010; received in revised form 28 June 2010; accepted 22 July 2010. published online 27 August 2010.

Abstract

MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post-transcriptional level. Accumulating evidence indicated that miRNAs are aberrantly expressed in a variety of human cancers and crucial to tumorigenesis. We herein provide a brief review of miRNA biogenesis, function, deregulation and their possible role as oncogenes or tumor suppressors in the pathogenesis of gastric cancer. The role of miRNAs in the carcinogenic effect of Helicobacter pylori infection was also discussed. Finally, we comment on the potential role of miRNAs in improving the current management of gastric cancer.

Keywords: MicroRNA, Gastric cancer, Diagnosis and therapy