Cancer Letters
Volume 305, Issue 2 , Pages 228-238, 28 June 2011

Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma

  • Sung Soo Kim

      Affiliations

    • Department of Internal Medicine, Uijongbu St. Mary Hospital, Catholic University of Korea, Seoul, Republic of Korea
    • ,
  • Victoria E. Ruiz

      Affiliations

    • Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, RI, United States
    • ,
  • Jaqueline D. Carroll

      Affiliations

    • Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, RI, United States
    • ,
  • Steven F. Moss

      Affiliations

    • Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, RI, United States
    • Corresponding Author InformationCorresponding author. Address: Gastroenterology Division, Rhode Island Hospital 593 Eddy Street, APC 414, Providence, RI 02903. Tel.: +1 401 444 6713; fax: +1 401 444 2939.

Received 1 April 2010; received in revised form 11 July 2010; accepted 13 July 2010. published online 09 August 2010.

Abstract 

Chronic gastric infection by the gram-negative bacterium Helicobacter pylori is strongly associated with the development of distal gastric carcinoma and gastric mucosal lymphoma in humans. Eradication of H. pylori with combination antibiotic therapy cures most cases of gastric lymphoma and slows progression to gastric adenocarcinoma. H. pylori promotes gastric neoplasia, principally via the induction of an intense gastric inflammatory response that lasts over decades. This persistent inflammatory state produces chronic oxidative stress and adaptive changes in gastric epithelial and immune cell pathobiology that in a minority of infected subjects eventually proceeds to frank neoplastic transformation.

Keywords: Helicobacter pylori infections, Gastric cancer, Lymphoma, Mechanisms, Inflammation, Carcinogenesis

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PII: S0304-3835(10)00362-9

doi:10.1016/j.canlet.2010.07.014

Cancer Letters
Volume 305, Issue 2 , Pages 228-238, 28 June 2011

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