Cancer Letters
Volume 297, Issue 1 , Pages 84-90 , 1 November 2010

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I – Thymidine kinase/ganciclovir in glioma

  • Su Jin Jang

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • Department of Biotechnology, Sejong University, Seoul 143-747, Republic of Korea
    • ,
  • Joo Hyun Kang

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Kwang Il Kim

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Tae Sup Lee

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Yong Jin Lee

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Kyo Chul Lee

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Kwang Sun Woo

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Wee Sup Chung

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Hee Chung Kwon

      Affiliations

    • Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Chun Jeih Ryu

      Affiliations

    • Department of Biotechnology, Sejong University, Seoul 143-747, Republic of Korea
    • ,
  • Tae Hyun Choi

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Chang Woon Choi

      Affiliations

    • Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Sang Moo Lim

      Affiliations

    • Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • ,
  • Gi Jeong Cheon

      Affiliations

    • Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea
    • Corresponding Author InformationCorresponding author at: Molecular Imaging Research Center and Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), 75 Nowon-gil, Gongneung-Dong, Nowon-Gu, Seoul 139-706, Republic of Korea. Tel.: +82 2 970 1273; fax: +82 2 970 1341.

Received 17 February 2010 ,Revised 21 April 2010 ,Accepted 30 April 2010.

References 

  1. Springer CJ, Niculescu-Duvaz I. Prodrug-activating systems in suicide gene therapy. J. Clin. Invest. 2000;105:1161–1167
  2. Yazawa K, Fisher WE, Brunicardi FC. Current progress in suicide gene therapy for cancer. World J. Surg. 2002;26:783–789
  3. Bansal K, Engelhard HH. Gene therapy for brain tumors. Curr. Oncol. Rep. 2000;2:463–472
  4. Anderson WF. Gene therapy scores against cancer. Nat. Med. 2000;6:862–863
  5. Fillat C, Carrió M, Cascante A, Sangro B. Suicide gene therapy mediated by herpes simplex virus thymidine kinase gene/ganciclovir system: 15 years of application. Curr. Gene Ther. 2003;3:13–26
  6. De Clercq E. Guanosine analogues as anti-herpesvirus agents. Nucleos. Nucleot. Nucl. Acids. 2001;19:1531–1541
  7. De Clercq E, Andrei G, Snoeck R, De Bolle , Naesens L, Degrève B, et al. Acyclic/carbicyclic guanosine analogues as anti-herpesvirus agents. Nucleos. Nucleot. Nucl. Acids. 2001;20:271–285
  8. Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL, et al. The ‘bystander effect’: tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 1993;53:5274–5283
  9. Mesnil M, Yamasaki H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res. 2000;60:3989–3999
  10. Gambhir SS, Herschman HR, Cherry SR, Barrio JR, Satyamurthy N, Toyokuni T, et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia. 2000;2:118–138
  11. Serganova I, Blasberg R. Reporter gene imaging: potential impact on therapy. Nucl. Med. Biol. 2005;32:763–780
  12. Kang JH, Chung JK. Molecular-genetic imaging based on reporter gene expression. J. Nucl. Med. 2008;49:164S–179S
  13. Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003;17:545–580
  14. Iyer M, Sato M, Johnson M, Gambhir SS, Wu L. Applications of molecular imaging in cancer therapy. Curr. Gene Ther. 2005;59:607–618
  15. Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, et al. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J. Nucl. Med. 2002;43:1072–1083
  16. Gambhir SS, Barrio JR, Wu L, Iyer M, Namvari M, Satyamurthy N, et al. Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J. Nucl. Med. 1998;39:2003–2011
  17. Kang KW, Min JJ, Chen X, Gambhir SS. Comparison of [14C]FMAU, [3H]FEAU, [14C]FIAU, and [3H]PCV for monitoring reporter gene expression of wild type and mutant herpes simplex virus type 1 thymidine kinase in cell culture. Mol. Imag. Biol. 2005;7:296–303
  18. Min JJ, Iyer M, Gambhir SS. Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs. stable transfection. Eur. J. Nucl. Med. Mol. Imag. 2003;30:1547–1560
  19. Perry JR, DeAngelis LM, Schold SC, Burger PC, Brem H, Brown MT, et al. Challenges in the design and conduct of phase III brain tumor therapy trials. Neurology. 1997;49:912–917
  20. Culver KW, Ram Z, Walbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector producer cells for treatment of experimental brain tumors. Science. 1992;256:1550–1552
  21. Vincent AJPE, Vogels R, Van Someren G, Esandi MC, Noteboom JL, Avezaat CJJ, et al. Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors. Human Gene Ther. 1996;7:197–205
  22. Okada H, Miyamura K, Itoh T, Hagiwara M, Wakabayashi T, Mizuno M, et al. Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Ther. 1996;3:957–964
  23. Kramm CM, Chase M, Herrlinger U, Jacobs A, Pechan PA, Rainov NG, et al. Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy. Human Gene Ther. 1997;8:2057–2068
  24. Trask TW, Trask RP, Aguilar-Cordova E, Shine HD, Wyde PR, Goodman JC, et al. Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol. Ther. 2000;1:195–203
  25. Engelhard HH. Gene therapy for brain tumors: the fundamentals. Surg. Neurol. 2000;54:3–9
  26. Contag CH, Jenkins D, Contag PR, Negrin RS. Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia. 2000;2:41–52
  27. Wu JC, Sundaresan G, Iyer M, Gambhir SS. Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice. Mol. Ther. 2001;4:297–306
  28. Shin JH, Chung JK, Kang JH, Lee YJ, Kim KI, So Y, et al. Non-invasive imaging for monitoring of viable cancer cells using dual-imaging reporter gene. J. Nucl. Med. 2004;45:2109–2115
  29. Soling A, Theiss C, Jungmichel S, Rainov NG. A dual function fusion protein of herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma. Genet. Vaccines Ther. 2004;2:7
  30. Jacobs A, Voges J, Reszka R, Lercher M, Gossmann A, Kracht L, et al. Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet. 2001;9283:727–729
  31. Ponomarev V, Doubrovin M, Serganova I, Vider J, Shavrin A, Beresten T, et al. A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur. J. Nucl. Med. Mol. Imag. 2004;31:740–751
  32. Ray P, De A, Min JJ, Tsien RY, Gambhir SS. Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res. 2004;64:1323–1330

PII: S0304-3835(10)00252-1

doi: 10.1016/j.canlet.2010.04.028

Cancer Letters
Volume 297, Issue 1 , Pages 84-90 , 1 November 2010

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