Cancer Letters
Volume 297, Issue 1 , Pages 65-74, 1 November 2010

RXRγ and PPARγ ligands in combination to inhibit proliferation and invasiveness in colon cancer cells

  • Alessio Papi

      Affiliations

    • Department of Experimental Evolutionary Biology, University of Bologna, via Selmi, 3, 40126 Bologna, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0512094131.
    • ,
  • Paola Rocchi

      Affiliations

    • Department of Experimental Pathology, viale Filopanti, 22, University of Bologna, 40126 Bologna, Italy
    • ,
  • Anna Maria Ferreri

      Affiliations

    • Department of Experimental Pathology, viale Filopanti, 22, University of Bologna, 40126 Bologna, Italy
    • ,
  • Marina Orlandi

      Affiliations

    • Department of Experimental Evolutionary Biology, University of Bologna, via Selmi, 3, 40126 Bologna, Italy

Received 15 March 2010; received in revised form 21 April 2010; accepted 27 April 2010. published online 01 June 2010.

Abstract 

Nuclear retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs are potential candidates as drug target for cancer prevention and treatment. We investigated if the rexinoid 6-OH-11-O-hydroxyphenantrene (IIF) potentiates the antitumoral properties of PPARγ ligands as ciglitazone and pioglitazone, on two colon cancer cell lines: HCA-7 and HCT-116. Drugs inhibited cell growth and induced apoptosis synergistically. The combination resulted in a decrease of cyclooxigenase-2, metalloproteinases-2 and -9 expression level and activity while PPARγ, RXRγ and tissue inhibitors of metalloproteinase-1 and -2 expression were increased. Finally, IIF potentiated PPAR transcriptional activity by enhancement of peroxisome proliferator response elements transactivation.

Keywords: Rexinoid, Tiazolinedhione, Metalloproteinases, Apoptosis, Invasion

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PII: S0304-3835(10)00241-7

doi:10.1016/j.canlet.2010.04.026

Cancer Letters
Volume 297, Issue 1 , Pages 65-74, 1 November 2010

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