Cancer Letters
Volume 297, Issue 1 , Pages 49-55, 1 November 2010

Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma

  • Nelson S. Yee

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: University of Iowa, Carver College of Medicine, CBRB Room 3269B, 500 Newton Road, Iowa City, IA 52242, USA. Tel.: +1 319 335 8106; fax: +1 319 384 4691.
    • ,
  • Weiqiang Zhou

      Affiliations

    • Present address: Clinic Medicine and Pharmacy College of China Medical University, Shenyang City, Liaoning Province 110002, People’s Republic of China.
    • ,
  • Minsun Lee

Received 4 December 2009; received in revised form 26 April 2010; accepted 27 April 2010. published online 02 June 2010.

Abstract 

The roles of transient receptor potential (TRP) cation channels in pancreatic tumorigenesis are essentially unknown. Here, we focus on the TRP melastatin-subfamily (TRPM) members. Expression of the thermally regulated transmembrane Ca2+-permeable channel TRPM8 is consistently up-regulated in human pancreatic adenocarcinoma cell lines and tissues. TRPM8-deficient pancreatic cancer cells have reduced ability of proliferation and cell cycle progression with elevated levels of cyclin-dependent kinase inhibitors. These results indicate that TRPM8 is aberrantly over-expressed in pancreatic adenocarcinoma and required for cellular proliferation, and they support further investigation of the potential of TRPM8 as a clinical biomarker and therapeutic target in pancreatic adenocarcinoma.

Keywords: Transient receptor potential (TRP), TRPM8, Ion channel, Proliferation, Pancreatic cancer

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0304-3835(10)00238-7

doi:10.1016/j.canlet.2010.04.023

Cancer Letters
Volume 297, Issue 1 , Pages 49-55, 1 November 2010

Article Tools

* Image Usage & Resolution