Cancer Letters
Volume 297, Issue 1 , Pages 9-17 , 1 November 2010

Gankyrin promotes the proliferation of human pancreatic cancer

Received 8 January 2010 ,Revised 12 April 2010 ,Accepted 22 April 2010.

References 

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J. Clin. 2009;59:225–249
  2. Mendieta Zeron H, Garcia Flores JR, Romero Prieto ML. Limitations in improving detection of pancreatic adenocarcinoma. Future Oncol. 2009;5:657–668
  3. Wong HH, Lemoine NR. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat. Rev. Gastroenterol. Hepatol. 2009;6:412–422
  4. Hori T, Kato S, Saeki M, DeMartino GN, Slaughter CA, Takeuchi J, et al. CDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene. 1998;216:113–122
  5. Yuan C, Li J, Mahajan A, Poi MJ, Byeon IJ, Tsai MD. Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure–function relationship. Biochemistry. 2004;43:12152–12161
  6. Manjasetty BA, Quedenau C, Sievert V, Bussow K, Niesen F, Delbruck H, et al. X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. Proteins. 2004;55:214–217
  7. Fu XY, Wang HY, Tan L, Liu SQ, Cao HF, Wu MC. Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance. World J. Gastroenterol. 2002;8:638–643
  8. Umemura A, Itoh Y, Itoh K, Yamaguchi K, Nakajima T, Higashitsuji H, et al. Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma. Hepatology. 2008;47:493–502
  9. Iwai A, Marusawa H, Kiuchi T, Higashitsuji H, Tanaka K, Fujita J, et al. Role of a novel oncogenic protein, gankyrin, in hepatocyte proliferation. J. Gastroenterol. 2003;38:751–758
  10. Ortiz CM, Ito T, Tanaka E, Tsunoda S, Nagayama S, Sakai Y, et al. Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance. Int. J. Cancer. 2008;122:325–332
  11. Tang S, Yang G, Meng Y, Du R, Li X, Fan R, et al. Overexpression of a novel gene gankyrin correlates with the malignant phenotype of colorectal cancer. Cancer Biol. Ther. 2010;9:1–8
  12. Dawson S, Apcher S, Mee M, Higashitsuji H, Baker R, Uhle S, et al. Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome. J. Biol. Chem. 2002;277:10893–10902
  13. Dawson S, Higashitsuji H, Wilkinson AJ, Fujita J, Mayer RJ. Gankyrin: a new oncoprotein and regulator of pRb and p53. Trends Cell Biol. 2006;16:229–233
  14. Chen J. Establishment and studies of two human pancreatic carcinoma in vivo lines by transplanting the tumor into nude mice. Chinese J. Pathol. 1989;18:197–200
  15. Pan Y, Bi F, Liu N, Xue Y, Yao X, Zheng Y, et al. Expression of seven main Rho family members in gastric carcinoma. Biochem. Biophys. Res. Commun. 2004;315:686–691
  16. van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res. 2000;60:5832–5838
  17. Liu N, Bi F, Pan Y, Sun L, Xue Y, Shi Y, et al. Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity. Clin. Cancer Res. 2004;10:6239–6247
  18. Jin H, Pan Y, Zhao L, Zhai H, Li X, Sun L, et al. P75 neurotrophin receptor suppresses the proliferation of human gastric cancer cells. Neoplasia. 2007;9:471–478
  19. He L, Wang H, Jin H, Guo C, Xie H, Yan K, et al. CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma. Cancer Lett. 2009;276:88–94
  20. Li X, Zhang Y, Xiong C, Jin H, Jing B, Fan D. Overexpression of a new gene P28GANK confers multidrug resistance of gastric cancer cells. Cancer Invest. 2009;27:129–139
  21. Chen X, Zhang M, Liu LX. The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells. Oncol. Rep. 2009;22:73–80
  22. Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A, et al. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist. Updat. 2007;10:13–29
  23. Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 1998;18:753–761
  24. Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 1995;15:2612–2624
  25. Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J. 1992;11:961–971
  26. Miller FD, Kaplan DR. Neurotrophin signalling pathways regulating neuronal apoptosis. Cell. Mol. Life Sci. 2001;58:1045–1053
  27. Sherr CJ. The INK4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2001;2:731–737

PII: S0304-3835(10)00234-X

doi: 10.1016/j.canlet.2010.04.019

Cancer Letters
Volume 297, Issue 1 , Pages 9-17 , 1 November 2010