Cancer Letters
Volume 297, Issue 1 , Pages 9-17, 1 November 2010

Gankyrin promotes the proliferation of human pancreatic cancer

State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 17 Changle Western Road, Xi’an 710032, China

Received 8 January 2010; received in revised form 12 April 2010; accepted 22 April 2010. published online 19 May 2010.

Abstract 

Previous studies in our laboratory have suggested that gankyrin expression is correlated with a malignant phenotype in colorectal cancer. Here, we investigated the possible role of gankyrin in pancreatic carcinogenesis. Gankyrin expression was significantly increased in pancreatic cancer compared to non-cancerous tissues. This expression significantly enhanced cancer cell proliferation and growth in vitro and in vivo. Suppression of gankyrin downregulated cyclin A, cyclin D1, cyclin E, CDK2, CDK4, PCNA and p-Rb but upregulated p27, Rb and p53. However, gankyrin overexpression led to opposite results. Thus, gankyrin could enhance pancreatic cancer cell proliferation by promoting cell cycle progression and p53 degradation.

Keywords: Gankyrin, Proliferation, Pancreatic cancer, Cell cycle

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PII: S0304-3835(10)00234-X

doi:10.1016/j.canlet.2010.04.019

Cancer Letters
Volume 297, Issue 1 , Pages 9-17, 1 November 2010

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