Cancer Letters
Volume 295, Issue 1 , Pages 85-91 , 1 September 2010

Histone deacetylase inhibitor FR235222 sensitizes human prostate adenocarcinoma cells to apoptosis through up-regulation of Annexin A1

  • Cosimo Walter D’Acunto

      Affiliations

    • Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
  • ,
  • Bianca Fontanella

      Affiliations

    • Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
  • ,
  • Manuela Rodriquez

      Affiliations

    • Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
  • ,
  • Maurizio Taddei

      Affiliations

    • Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Siena, Italy
  • ,
  • Luca Parente

      Affiliations

    • Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
  • ,
  • Antonello Petrella

      Affiliations

    • Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy
    • Corresponding Author InformationCorresponding author. Address: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy. Tel.: +39 089 969762; fax: +39 089 969602.

Received 12 January 2010 ,Revised 17 February 2010 ,Accepted 19 February 2010.

References 

  1. Gerke V, Moss SE. Annexins: from structure to functions. Physiol. Rev. 2002;82:331–371
  2. Parente L, Solito E. Annexin 1 more than an anti-phospholipase protein. Inflamm. Res. 2004;53:125–132
  3. Solito E, de Coupade C, Canaider S, Goulding NJ, Perretti M. Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. Br. J. Pharmacol. 2001;133:217–228
  4. Debret R, El Btaouri H, Duca L, Rahman I, Radke S, Haye B, et al. Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells. FEBS Lett. 2003;546:195–202
  5. Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E, et al. Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells. Cell Death Diff. 2005;12:1358–1360
  6. Paweletz CP, Ornstein DK, Roth MJ, Bichsel VE, Gillespie JW, Calvert VS, et al. Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma. Cancer Res. 2000;60:6293–6297
  7. Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, et al. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Cancer Res. 2001;61:889–895
  8. Xia SH, Hu LP, Hu H, Ying WT, Xu X, Cai Y, et al. Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but down-regulated in esophageal squamous cell carcinomas. Oncogene. 2002;21:6641–6648
  9. Xin W, Rhodes DR, Ingold C, Chinnaiyan AM, Rubin MA. Dysregulation of the annexin family protein family is associated with prostate cancer progression. Am. J. Pathol. 2003;162:255–261
  10. Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E, et al. Annexin-1 down-regulation in thyroid cancer correlates to the degree of tumour differentiation. Cancer Biol. Ther. 2006;5:643–647
  11. Kang JS, Calvo BF, Maygarden SJ, Caskey LS, Mohler JL, Ornstein DK. Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Clin. Cancer Res. 2002;8:117–123
  12. Hsiang CH, Tunoda T, Whang YE, Tyson DR, Ornstein DK. The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells. Prostate. 2006;66:1413–1424
  13. Strahl BD, Allis CD. The language of covalent histone modifications. Nature. 2000;403:4041–4045
  14. Gregory PD, Wagner K, Horz W. Histone acetylation and chromatin remodeling. Exp. Cell Res. 2001;265:195–202
  15. Mahlknecht U, Hoelzer D. Histone acetylation modifiers in the pathogenesis of malignant disease. Mol. Med. 2000;6:623–644
  16. Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr. Med. Chem. 2001;8:1505–1511
  17. Emanuele S, Lauricella M, Tesoriere G. Histone deacetylase inhibitors: apoptotic effects and clinical implications. Int. J. Oncol. 2008;33:637–646
  18. Mori H, Urano Y, Abe F, Furukawa S, Furukawa S, Tsurumi Y, et al. FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation, and biological activities. J. Antibiot. (Tokyo). 2003;56:72–79
  19. Petrella A, D’Acunto W, Rodriquez M, Festa M, Tosco A, Bruno I, et al. Effects of FR235222, a novel HDAC inhibitor, in proliferation and apoptosis of human leukemia cell lines: role of annexin A1. Eur. J. Cancer. 2008;44:740–749
  20. Tabe Y, Jin L, Contractor R, Gold D, Ruvolo P, Radke S, et al. Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1. Cell Death Diff. 2007;14:1443–1456
  21. Rodriquez M, Terracciano S, Cini E, Settembrini G, Bruno I, Bifulco G, et al. Total synthesis, NMR solution structure, and binding model of the potent histone deacetylase inhibitor FR235222. Angew. Chem. Int. Ed. Engl. 2006;45:423–427
  22. Johnson MI, Robinson MC, Marsh C, Robson CN, Neal DE, Hamdy FC. Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation. Prostate. 1998;37:223–229
  23. Cang S, Feng J, Konno S, Han L, Liu K, Sharma SC, et al. Deficient histone acetylation and excessive deacetylase activity as epigenomic marks of prostate cancer cells. Int. J. Oncol. 2009;35:1417–1422
  24. Abbas A, Gupta S. The role of histone deacetylases in prostate cancer. Epigenetics. 2008;3:300–309
  25. Yen CC, Chen YJ, Chen JT, Hsia JY, Chen PM, Liu LH, et al. Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis. Cancer. 2001;92:2769–2777
  26. Fang Y, Guan X, Guo Y, Sham J, Deng M, Liang Q, et al. Analysis of genetic alterations in primary nasopharyngeal carcinoma by comparative genomic hybridization. Genes Chromosomes Cancer. 2001;30:254–260

PII: S0304-3835(10)00117-5

doi: 10.1016/j.canlet.2010.02.016

Cancer Letters
Volume 295, Issue 1 , Pages 85-91 , 1 September 2010