Cancer Letters
Volume 294, Issue 2 , Pages 135-138 , 28 August 2010

Aquaporins in tumor growth and angiogenesis

  • Beatrice Nico
    • ,
  • Domenico Ribatti

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11 Policlinico, 70124 Bari, Italy. Tel.: +39 080 5478240; fax: +39 080 5478310.

Received 13 January 2010 ,Revised 10 February 2010 ,Accepted 10 February 2010.

References 

  1. King LS, Agre P. Pathophysiology of the aquaporin water channels. Annu. Rev. Physiol. 1996;58:619–648
  2. Verkman AS. More than just water channels: unexpected cellular roles of aquaporins. J. Cell Sci. 2005;118:3225–3232
  3. Saadoun S, Papadopoulos MC, Davies DC, Krishna S, Bell BA. Aquaporin-4 expression is increased in oedematous human brain tumours. J. Neurol. Neurosurg. Pscychiatry. 2002;72:262–265
  4. Warth A, Kroger S, Wolburg H. Redistribution of aquaporin 4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol. 2004;107:311–318
  5. Warth A, Simon P, Capper D, Goeppert B, Tabatabai G, Herzog H, et al. Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival. J. Neurosci. Res. 2007;85:1336–1345
  6. Endo M, Jain RK, Witwer B, Brown D. Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas. Microvasc. Res. 1999;58:89–98
  7. Moon C, Soria JC, Jang SJ, Lee J, Hoque MO, Sibonu M, et al. Involvement of aquaporins in colorectal carcinogenesis. Oncogene. 2003;22:6699–8703
  8. Saadoun S, Papadopoulos MC, Davies DC, Bell BA, Krishna S. Increased aquaporin 1 water channel expression in human brain tumors. Br. J. Cancer. 2002;87:621–623
  9. Chen Y, Tachibana O, Oda M, Xu R, Hamada J, Yamashita J, et al. Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation. J. Neurooncol. 2006;80:219–225
  10. Vacca A, Frigeri A, Ribatti D, Nicchia GP, Nico B, Ria R, et al. Microvessel overexpression of aquaporin-1 parallels bone marrow angiogenesis in patients with active multiple myeloma. Br. J. Haematol. 2001;113:415–421
  11. Hoque MO, Soria JC, Woo J, Lee T, Lee J, Jang SJ, et al. Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am. J. Pathol. 2001;168:1345–1353
  12. Saadoun S, Papadoulos MC, Hara-Chikuma M, Verkman S. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786–792
  13. Hu J, Verkman S. Increased migration and metastatic potential of tumor cells expressing aquaporin water channels. FASEB J. 2006;20:1892–1894
  14. Nilesen S, Smith BL, Christensen EI, Knepper MA, Agree P. CHIP 28 water channels are localized in constitutively water-permeable segments of the nephron. J. Cell Biol. 1993;120:371–383
  15. Shanahan CM, Commolly DL, Tyson KL, Carry NRB, Osborn JK, Agree P, et al. Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes. J. Vasc. Res. 1999;36:353–362
  16. Pallone TL, Kishore BK, Nielsen S, Agree P, Knepper MA. Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta. Am. J. Physiol. 1994;36:R260–R267
  17. Pallone TL, Edwards A, Silldorrff EP, Vermann AS. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J. Clin. Invest. 2000;105:215–222
  18. Devust O, Nilesen S, Cosyns JP, Smith BL, Agree P, Squifflet JP, et al. Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelial of human peritoneum. Am. J. Physiol. 1998;275:H234–H242
  19. Ribatti D, Frigeri A, Nico B, Nicchia GP, De Giorgis M, Roncali L, et al. Aquaporin-1 expression in the chick embryo chorioallantoic membrane. Anat. Rec. 2002;268:85–89
  20. Camerino GM, Nicchia GP, Dinardo MM, Ribatti D, Svelto M, Frigeri A. In vivo silencing of aquaporin-1 by RNA interference inhibits angiogenesis in the chick embryo chorioallantoic membrane assay. Cell Mol. Biol. 2006;52:51–56
  21. Pan H, Sun CC, Zhou CY, Huang HF. Expression of aquaporin-1 in normal, hyperplastic and carcinomatous endometria. Int. J. Gynaecol. Obstet. 2008;101:239–244
  22. Yang JH, Shi YF, Chen XD, Qi WJ. The influence of aquaporin-1 and microvessel density on ovarian carcinogenesis and ascite formation. Int. J. Gynecol. Cancer. 2006;16(Suppl. 1):400–405
  23. Yang JH, Shi YF, Cheng Q, Deng L. Expression and localization of aquaporin-5 in the epithelial ovarian tumors. Gynecol. Oncol. 2006;100:294–299
  24. Kaneko K, Yagui K, Tanaka A, Yoshihara K, Ishikawa K, Takahashi K, et al. Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc. Res. 2008;75:297–301
  25. Jiang Y. Aquaporin-1 activity of plasma membrane affects HT20 colon cancer migration. IUBMB Life. 2009;61:1001–1009
  26. Otterbach F, Calliers R, Kimmig R, Schmid KW, Bankfalvi A. Aquaporin-1 expression in invasive breast carcinoma. Pathologie. 2008;29(Suppl. 2):357–362
  27. Hara-Chikuma M, Verkman AS. Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin 3 gene disruption. Mol. Cell Biol. 2008;98:326–332
  28. Hara-Chikuma M, Verkman AS. Roles of aquaporin-3 in the epidermis. J. Invest. Dermatol. 2008;128:2145–2151
  29. Liu YL, Matsuzaki T, Nakazawa T, Murata S, Nakamura N, Kondo T, et al. Expression of aquaporin-3 (AQP3) in normal and neoplastic lung tissues. Hum. Pathol. 2007;38:171–178
  30. Ismail M, Bokaee S, Morgan R, Davies J, Harrington KJ, Pandaia H. Inhibition of the aquaporin 3 water channel increases the sensitivity of prostate cancer cells to cryotherapy. Br. J. Cancer. 2009;100:1889–1895
  31. Badaut J, Lasbennes F, Magistretti PJ, Regli L. Aquaporins in brain: distribution, physiology and pathophysiology. J. Ceram. Blood Flow Metab. 2002;22:367–378
  32. Manley GT, Binder DK, Papafopoulos MC, Verkman AS. New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience. 2004;129:983–991
  33. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004;18:1291–1293
  34. Papadopoulos MC, Verkman AS. Aquaporin-4 and brain edema. Pediatr. Nephrol. 2007;22:778–784
  35. Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS. Molecular mechanism of brain tumor edema. Neuroscience. 2004;129:1011–1020
  36. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat. Med. 2000;6:159–163
  37. Warth A, Mittelbronn M, Wolburg H. Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir 4.1 differs in low- and high-grade human brain tumors. Acta Neuropathol. 2005;109:418–426
  38. Nico B, Mangieri D, Tamma R, Longo V, Annese T, Crivellato E, et al. Aquaporin-4 contributes to the resolution of peritumoral brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy. Eur. J. Cancer. 2009;45:3315–3325
  39. E.S. McCoy, B.R. Haas, H. Sontheimer, Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion, Neuroscience 15(September) (2009). [Epub ahead of print].
  40. Ng WH, Hy JW, Tan WL, Liev D, Lim T, Ang BT, et al. Aquaporin-4 expression is increased in edematous meningiomas. J. Clin. Neurosci. 2009;16:441–443
  41. Burghardt B, Elkaer ML, Kwon TH, Racz GZ, Varga G, Steward MC, et al. Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut. 2003;52:1008–1016
  42. Woo J, Lee J, Chae YK, Kim MS, Baek JH, Park JC, et al. Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett. 2008;264:54–62
  43. Kang SK, Chae YK, Woo J, Kim MS, Park JC, Lee J, et al. Role of human aquaporin-5 in colorectal carcinogenesis. Am. J. Pathol. 2008;173:518–525
  44. Chae YK, Kang SK, Kim MS, Woo J, Lee J, Chang S, et al. Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS One. 2008;3:e2594
  45. Chae YK, Woo J, Kim MJ, Kang SK, Kim MS, Lee J, et al. Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS One. 2008;3:e2162
  46. Jablonski EM, Mattocks AM, Sokolov E, Koniaris LG, Hughes Jr FM, Fausto N, et al. Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. Cancer Lett. 2007;250:36–46
  47. Monzani E, Shtil AA, La Porta CA. The water channels, new druggable targets to combat cancer cell survival, invasiveness and metastasis. Curr. Drug Targets. 2007;8:1132–1137
  48. Pedersen SF, Hoffmann EK, Millis JW. The cytoskeleton and cell volume regulation. Comp. Biochem. Physiol. 2001;130:385–399
  49. Ma B, Xiang Y, Li T, Yu HM, Li XJ. Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel. Acta Pharmacol. Sin. 2004;25:54–60
  50. Xiang Y, Ma B, Li T. Acetozalamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma. Acta Pharmacol. Sin. 2002;23:751–754
  51. Ma B, Xinag Y, Li T. Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel. Acta Pharmacol. Sin. 2004;25:54–60

PII: S0304-3835(10)00093-5

doi: 10.1016/j.canlet.2010.02.005

Cancer Letters
Volume 294, Issue 2 , Pages 135-138 , 28 August 2010

Article Tools