Cancer Letters
Volume 294, Issue 2 , Pages 135-138, 28 August 2010

Aquaporins in tumor growth and angiogenesis

  • Beatrice Nico
    • ,
  • Domenico Ribatti

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11 Policlinico, 70124 Bari, Italy. Tel.: +39 080 5478240; fax: +39 080 5478310.

Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

Received 13 January 2010; received in revised form 10 February 2010; accepted 10 February 2010. published online 03 March 2010.

Abstract 

The aquaporins (AQPs) are a family of transmembrane water channel proteins widely distributed and play a major role in transcellular and transepithelial water movement. Moreover, recent evidence indicates that AQPs may be involved in cell migration and angiogenesis. This review article summarizes literature data concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process and suggest a potential therapeutic approach by antagonizing their biological activity.

Keywords: Angiogenesis, Aquaporins, Metastastis, Tumor growth

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PII: S0304-3835(10)00093-5

doi:10.1016/j.canlet.2010.02.005

Cancer Letters
Volume 294, Issue 2 , Pages 135-138, 28 August 2010

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