Cancer Letters
Volume 294, Issue 2 , Pages 229-235 , 28 August 2010

Alcohol consumption promotes mammary tumor growth and insulin sensitivity

Received 2 December 2009 ,Revised 3 February 2010 ,Accepted 5 February 2010.

References 

  1. ACS, in: Breast Cancer Facts & Figures 2009–2010, American Cancer Society, Atlanta, 2009, pp. 1–36.
  2. Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA. 2001;286:2143–2151
  3. Boffetta P, Hashibe M, La Vecchia C, Zatonski W, Rehm J. The burden of cancer attributable to alcohol drinking. Int. J. Cancer. 2006;119:884–887
  4. Smith-Warner SA, Spiegelman D, Yaun SS, van den Brandt PA, Folsom AR, Goldbohm RA, et al. Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA. 1998;279:535–540
  5. Weiss HA, Brinton LA, Brogan D, Coates RJ, Gammon MD, Malone KE, et al. Epidemiology of in situ and invasive breast cancer in women aged under 45. Br. J. Cancer. 1996;73:1298–1305
  6. Stoll BA. Alcohol intake and late-stage promotion of breast cancer. Eur. J. Cancer. 1999;35:1653–1658
  7. Vaeth PA, Satariano WA. Alcohol consumption and breast cancer stage at diagnosis. Alcohol Clin. Exp. Res. 1998;22:928–934
  8. Ke Z, Lin H, Fan Z, Cai TQ, Kaplan RA, Ma C, et al. MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2. Int. J. Cancer. 2006;119:8–16
  9. Luo J. Role of matrix metalloproteinase-2 in ethanol-induced invasion by breast cancer cells. J. Gastroenterol. Hepatol. 2006;21(Suppl. 3):S65–S68
  10. Koppes LL, Dekker JM, Hendriks HF, Bouter LM, Heine RJ. Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care. 2005;28:719–725
  11. Davies MJ, Baer DJ, Judd JT, Brown ED, Campbell WS, Taylor PR. Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA. 2002;287:2559–2562
  12. Greenfield JR, Samaras K, Jenkins AB, Kelly PJ, Spector TD, Campbell LV. Moderate alcohol consumption, estrogen replacement therapy, and physical activity are associated with increased insulin sensitivity: is abdominal adiposity the mediator?. Diabetes Care. 2003;26:2734–2740
  13. Roth MJ, Baer DJ, Albert PS, Castonguay TW, Dorgan JF, Dawsey SM, et al. Relationship between serum leptin levels and alcohol consumption in a controlled feeding and alcohol ingestion study. J. Natl. Cancer Inst. 2003;95:1722–1725
  14. Huang Z, Sjoholm A. Ethanol acutely stimulates islet blood flow, amplifies insulin secretion, and induces hypoglycemia via nitric oxide and vagally mediated mechanisms. Endocrinology. 2008;149:232–236
  15. Nunez NP, Carter PA, Meadows GG. Alcohol consumption promotes body weight loss in melanoma-bearing mice. Alcohol Clin. Exp. Res. 2002;26:617–626
  16. Dorgan JF, Baer DJ, Albert PS, Judd JT, Brown ED, Corle DK, et al. Serum hormones and the alcohol–breast cancer association in postmenopausal women. J. Natl. Cancer Inst. 2001;93:710–715
  17. Gavaler JS, Rosenblum E. Exposure-dependent effects of ethanol on serum estradiol and uterus mass in sexually mature oophorectomized rats: a model for bilaterally ovariectomized-postmenopausal women. J. Stud. Alcohol. 1987;48:295–303
  18. Ginsburg ES, Walsh BW, Shea BF, Gao X, Gleason RE, Barbieri RL. The effects of ethanol on the clearance of estradiol in postmenopausal women. Fertil. Steril. 1995;63:1227–1230
  19. Sulkowska M, Golaszewska J, Wincewicz A, Koda M, Baltaziak M, Sulkowski S. Leptin – from regulation of fat metabolism to stimulation of breast cancer growth. Pathol. Oncol. Res. 2006;12:69–72
  20. Hong J, Smith RR, Harvey AE, Nunez NP. Alcohol consumption promotes insulin sensitivity without affecting body fat levels. Int. J. Obes. (Lond.). 2009;33:197–203
  21. Zilkens RR, Burke V, Watts G, Beilin LJ, Puddey IB. The effect of alcohol intake on insulin sensitivity in men: a randomized controlled trial. Diabetes Care. 2003;26:608–612
  22. Borowsky AD, Namba R, Young LJ, Hunter KW, Hodgson JG, Tepper CG, et al. Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior. Clin. Exp. Metast. 2005;22:47–59
  23. Williamson DF, Forman MR, Binkin NJ, Gentry EM, Remington PL, Trowbridge FL. Alcohol and body weight in United States adults. Am. J. Public Health. 1987;77:1324–1330
  24. Liu S, Serdula MK, Williamson DF, Mokdad AH, Byers T. A prospective study of alcohol intake and change in body weight among US adults. Am. J. Epidemiol. 1994;140:912–920
  25. Greenfield JR, Samaras K, Jenkins AB, Kelly PJ, Spector TD, Campbell LV. Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: evidence for gene–environment interaction. J. Clin. Endocrinol. Metab. 2003;88:5381–5386
  26. Wannamethee SG, Shaper AG, Whincup PH. Alcohol and adiposity: effects of quantity and type of drink and time relation with meals. Int. J. Obes. (Lond.). 2005;29:1436–1444
  27. Wannamethee SG, Field AE, Colditz GA, Rimm EB. Alcohol intake and 8-years weight gain in women: a prospective study. Obes. Res. 2004;12:1386–1396
  28. Shah M, Jeffery RW, Hannan PJ, Onstad L. Relationship between socio-demographic and behaviour variables, and body mass index in a population with high-normal blood pressure: hypertension prevention trial. Eur. J. Clin. Nutr. 1989;43:583–596
  29. Cirillo D, Rachiglio AM, la Montagna R, Giordano A, Normanno N. Leptin signaling in breast cancer: an overview. J. Cell Biochem. 2008;105:956–964
  30. Riant E, Waget A, Cogo H, Arnal JF, Burcelin R, Gourdy P. Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. Endocrinology. 2009;150:2109–2117
  31. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799–806
  32. Feng L, Gao L, Guan Q, Hou X, Wan Q, Wang X, et al. Long-term moderate ethanol consumption restores insulin sensitivity in high-fat-fed rats by increasing SLC2A4 (GLUT4) in the adipose tissue by AMP-activated protein kinase activation. J. Endocrinol. 2008;199:95–104
  33. Perez-Tenorio G, Stal O. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br. J. Cancer. 2002;86:540–545
  34. Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res. 2008;68:6084–6091
  35. Dumitrescu RG, Shields PG. The etiology of alcohol-induced breast cancer. Alcohol. 2005;35:213–225
  36. Aye MM, Ma C, Lin H, Bower KA, Wiggins RC, Luo J. Ethanol-induced in vitro invasion of breast cancer cells: the contribution of MMP-2 by fibroblasts. Int. J. Cancer. 2004;112:738–746
  37. Lew JQ, Freedman ND, Leitzmann MF, Brinton LA, Hoover RN, Hollenbeck AR, et al. Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP diet and health study. Am. J. Epidemiol. 2009;
  38. Wayne S, Neuhouser ML, Ulrich CM, Koprowski C, Wiggins C, Baumgartner KB, et al. Association between alcohol intake and serum sex hormones and peptides differs by tamoxifen use in breast cancer survivors. Cancer Epidemiol. Biomark. Prev. 2008;17:3224–3232
  39. O’Neil JS, Burow ME, Green AE, McLachlan JA, Henson MC. Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choriocarcinoma cells: selective regulation via estrogen receptors alpha and beta. Mol. Cell Endocrinol. 2001;176:67–75
  40. Suzuki R, Ye W, Rylander-Rudqvist T, Saji S, Colditz GA, Wolk A. Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: a prospective cohort study. J. Natl. Cancer Inst. 2005;97:1601–1608
  41. Caldefie-Chezet F, Damez M, de Latour M, Konska G, Mishellani F, Fusillier C, et al. Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem. Biophys. Res. Commun. 2005;334:737–741

PII: S0304-3835(10)00090-X

doi: 10.1016/j.canlet.2010.02.004

Cancer Letters
Volume 294, Issue 2 , Pages 229-235 , 28 August 2010