Cancer Letters
Volume 294, Issue 2 , Pages 187-194 , 28 August 2010

Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis

  • Marcelo De Franco

      Affiliations

    • Laboratory of Imunogenetics, Instituto Butantan, Avenida Dr. Vital Brazil, 1500, 05503-900, São Paulo, Brazil
    • These authors contributed equally to this work.
    • ,
  • Francesca Colombo

      Affiliations

    • Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    • These authors contributed equally to this work.
    • ,
  • Antonella Galvan

      Affiliations

    • Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Loris De Cecco

      Affiliations

    • Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    • ,
  • Elena Spada

      Affiliations

    • Istituto di Statistica Medica e Biometria “GA Maccacaro” Università di Milano, Milan, Italy
    • ,
  • Silvano Milani

      Affiliations

    • Istituto di Statistica Medica e Biometria “GA Maccacaro” Università di Milano, Milan, Italy
    • ,
  • Olga M. Ibanez

      Affiliations

    • Laboratory of Imunogenetics, Instituto Butantan, Avenida Dr. Vital Brazil, 1500, 05503-900, São Paulo, Brazil
    • Corresponding Author InformationCorresponding authors. Address: Laboratório de Imunogenética, Instituto Butantan, São Paulo, SP, Brazil (O.M. Ibanez), Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milan, Italy. Tel.: +39 0223902642; fax: +39 0223903237 (T.A. Dragani).
    • ,
  • Tommaso A. Dragani

      Affiliations

    • Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    • Corresponding Author InformationCorresponding authors. Address: Laboratório de Imunogenética, Instituto Butantan, São Paulo, SP, Brazil (O.M. Ibanez), Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milan, Italy. Tel.: +39 0223902642; fax: +39 0223903237 (T.A. Dragani).

Received 2 October 2009 ,Revised 28 January 2010 ,Accepted 29 January 2010.

References 

  1. Biozzi G, Ribeiro OG, Saran A, et al. Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse. Carcinogenesis. 1998;19:337–346
  2. Maria DA, Manenti G, Galbiati F, et al. Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response. Oncogene. 2003;22:426–432
  3. Fernando RC, Nair J, Barbin A, Miller JA, Bartsch H. Detection of 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine by immunoaffinity/32P-postlabelling in liver and lung DNA of mice treated with ethyl carbamate (urethane) or its metabolites. Carcinogenesis. 1996;17:1711–1718
  4. Hoffler U, El Masri HA, Ghanayem BI. Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice. J. Pharmacol. Exp. Ther. 2003;305:557–564
  5. Gariboldi M, Spinola M, Milani S, Pignatiello C, Kadota K, Bono H, et al. Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice. Carcinogenesis. 2003;24:1819–1826
  6. Riggs PK, Angel JM, Abel EL, DiGiovanni J. Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion. Mol. Carcinogen. 2005;44:122–136
  7. Fujiwara K, Ochiai M, Ubagai T, Ohki M, Ohta T, Nagao M, et al. Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat. Cancer Sci. 2003;94:672–678
  8. Falvella FS, Pascale RM, Gariboldi M, Manenti G, De Miglio MR, Simile MM, et al. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Carcinogenesis. 2002;23:1933–1936
  9. Wright GW, Simon RM. A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics. 2003;19:2448–2455
  10. Carmona-Saez P, Chagoyen M, Tirado F, Carazo JM, Pascual-Montano A. GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists. Genome Biol. 2007;8:R3
  11. Schnoor M, Parkos CA. Disassembly of endothelial and epithelial junctions during leukocyte transmigration. Front. Biosci. 2008;13:6638–6652
  12. Vestweber D. Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium. Immunol. Rev. 2007;218:178–196
  13. Suzuki K, Kumanogoh A, Kikutani H. Semaphorins and their receptors in immune cell interactions. Nat. Immunol. 2008;9:17–23
  14. Kruger RP, Aurandt J, Guan KL. Semaphorins command cells to move. Nat. Rev. Mol. Cell Biol. 2005;6:789–800
  15. Holmes S, Downs AM, Fosberry A, et al. Sema7A is a potent monocyte stimulator. Scand. J. Immunol. 2002;56:270–275
  16. Rettig L, McNeill L, Sarner N, Guillaume P, Luescher I, Tolaini M, et al. An essential role for the stalk region of CD8 beta in the coreceptor function of CD8. J. Immunol. 2009;182:121–129
  17. Inman BA, Frigola X, Dong H, Kwon ED. Costimulation, coinhibition and cancer. Curr. Cancer Drug Targets. 2007;7:15–30
  18. Noel PJ, Boise LH, Thompson CB. Regulation of T cell activation by CD28 and CTLA4. Adv. Exp. Med. Biol. 1996;406:209–217
  19. Ji H, Houghton AM, Mariani TJ, et al. K-ras activation generates an inflammatory response in lung tumors. Oncogene. 2006;25:2105–2112
  20. To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat. Genet. 2006;38:926–930
  21. Manenti G, Galbiati F, Giannì Barrera R, Pettinicchio A, Acevedo A, Dragani TA. Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Oncogene. 2004;23:4495–4504
  22. Manenti G, Dragani TA. Pas1 haplotype-dependent genetic predisposition to lung tumorigenesis in rodents: a meta-analysis. Carcinogenesis. 2005;26:875–882
  23. Lee S, Kang J, Cho M, et al. Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches. Int. J. Oncol. 2009;34:161–172
  24. Levine AJ, Hu W, Feng Z. The P53 pathway: what questions remain to be explored?. Cell Death Differ. 2006;13:1027–1036
  25. Ghanayem BI, Hoffler U. Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using Cyp2e1(-/-) mice. Curr. Drug Metab. 2007;8:728–749
  26. de Souza VR, Cabrera WK, Galvan A, Ribeiro OG, De Franco M, Vorraro F, et al. Aryl hydrocarbon receptor polymorphism modulates DMBA-induced inflammation and carcinogenesis in phenotypically selected mice. Int. J. Cancer. 2009;124:1478–1482

PII: S0304-3835(10)00074-1

doi: 10.1016/j.canlet.2010.01.038

Cancer Letters
Volume 294, Issue 2 , Pages 187-194 , 28 August 2010

Article Tools

* Image Usage & Resolution