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Cancer Letters
Volume 291, Issue 1
, Pages 120-129
, 1 May 2010
Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma
References
- . Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557–2576
- . Alcohol metabolism and cancer risk. Alcohol Res. Health. 2007;30:38–41pp. 44–47
- . Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007;8:292–293
- . Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer. 2006;6:674–687
- . Molecular pathogenesis of hepatocellular carcinoma. J. Surg. Res. 2006;136:125–135
- . Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol. Aspects Med. 2008;29:9–16
- . Alcohol and liver cancer. Alcohol. 2005;35:195–203
- . The activity of class I, II, III and IV alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in liver cancer. Dig. Dis. Sci. 2008;53:2550–2555
- . Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. Novartis Found. Symp. 2007;285:4–16(discussion pp. 16–22, 198–199)
- . CYP2E1 and oxidative liver injury by alcohol. Free Radic. Biol. Med. 2008;44:723–738
- . Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2 2A6 2E1 and 3A4 enzymes. Environ. Health Perspect. 1994;102(Suppl. 9):49–53
- . Mitochondrial glutathione: hepatocellular survival–death switch. J. Gastroenterol. Hepatol. 2006;21(Suppl. 3):S3–S6
- . S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J. Gastroenterol. Hepatol. 2008;23(Suppl. 1):S73–S77
- . S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Shock. 2008;30:197–205
- . Role of S-adenosyl-l-methionine in liver health and injury. Hepatology. 2007;45:1306–1312
- . S-adenosyl-l-methionine for alcoholic liver diseases. Cochrane Database Syst. Rev. 2006;CD002235
- . Herbal medicines for liver diseases. Dig. Dis. Sci. 2005;50:1807–1812
- . Multitargeted therapy of cancer by silymarin. Cancer Lett. 2008;269:352–362
- . An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed. 2008;15:9–20
- . Increased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. Cancer Lett. 2007;250:36–46
- . Inhibition of alcohol dehydrogenase blocks enhanced Gi-protein expression following ethanol treatment in experimental hepatocellular carcinoma in vitro. Eur. J. Gastroenterol. Hepatol. 2001;13:1209–1216
- . Microencapsulation of engineered cells to deliver sustained high circulating levels of interlukin-6 to study hepatocellular carcinoma progression. Cell Transplant. 2006;15:785–798
- . Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. Mol. Pharmacol. 1986;29:399–404
- . Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 2007;26:3291–3310
- . Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. Hepatology. 1997;26:1484–1491
- . Recent advances in alcohol-induced adduct formation. Alcohol. Clin. Exp. Res. 2005;29:1310–1316
- . Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2 through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur. J. Pharmacol. 2008;591:13–20
- . Effects and mechanisms of silibinin on human hepatoma cell lines. World J. Gastroenterol. 2007;13:5299–5305
- . A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin–phosphatidylcholine complex (Siliphos). Altern. Med. Rev. 2005;10:193–203
- . Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. J. Pharm. Biomed. Anal. 2007;45:635–641
- . Cell cycle control as a basis for cancer chemoprevention through dietary agents. Front. Biosci. 2008;13:2191–2202
- . Silibinin efficacy against human hepatocellular carcinoma. Clin. Cancer Res. 2005;11:8441–8448
- . A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutat. Res. 2004;555:21–32
- . Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Cochrane Database Syst. Rev. 2007;CD003620
- . Silybin and silymarin – new and emerging applications in medicine. Curr. Med. Chem. 2007;14:315–338
- . Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2E1. Chem. Biol. Interact. 1994;91:51–63
- . Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol?. Alcohol Clin. Exp. Res. 2005;29:166S–171S
- . Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal, kinase, and apoptosis. J. Immunol. 1999;163:6800–6809
- . Assessing bioflavonoids as regulators of NF-kappa B activity and inflammatory gene expression in mammalian cells. Methods Enzymol. 2001;335:380–387
- . Inflammatory pathways in liver homeostasis and liver injury. Clin. Rev. Allergy Immunol. 2009;36:4–12
- . Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol. Sci. 2004;80:14–25
- . Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats. J. Steroid. Biochem. Mol. Biol. 2003;86:179–188
- . Influence of alcohol and gender on immune response. Alcohol Res. Health. 2002;26:257–263
- . Alcohol-induced disruption of endocrine signaling. Alcohol. Clin. Exp. Res. 2007;31:1269–1285
- . Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res. 2008;68:2043–2050
PII: S0304-3835(09)00626-0
doi: 10.1016/j.canlet.2009.10.004
© 2009 Elsevier Ireland Ltd. All rights reserved.
« Previous
Cancer Letters
Volume 291, Issue 1
, Pages 120-129
, 1 May 2010
