Cancer Letters
Volume 291, Issue 1 , Pages 120-129, 1 May 2010

Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma

  • Elizabeth Brandon-Warner

      Affiliations

    • Department of Biology, The University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, NC 28223, USA
    • Department of General Surgery, Carolinas Medical Center, 1000 Blythe Blvd., Charlotte, NC 28203, USA
    • ,
  • James A. Sugg

      Affiliations

    • Department of Biology, The University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, NC 28223, USA
    • ,
  • Laura W. Schrum

      Affiliations

    • Department of Biology, The University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, NC 28223, USA
    • ,
  • Iain H. McKillop

      Affiliations

    • Department of General Surgery, Carolinas Medical Center, 1000 Blythe Blvd., Charlotte, NC 28203, USA
    • Corresponding Author InformationCorresponding author. Address: Department of General Surgery, Carolinas Medical Center, Cannon Research Building, Room 402, 1000 Blythe Blvd, Charlotte, NC 28203, USA. Tel.: +1 44 1 704 355 2846; fax: +1 44 1 704 355 7202.

Received 2 June 2009; received in revised form 5 October 2009; accepted 8 October 2009. published online 09 November 2009.

Abstract 

Chronic ethanol consumption is a known risk factor for developing hepatocellular carcinoma (HCC). The use of plant-derived antioxidants is gaining increasing clinical prominence as a potential therapy to ameliorate the effects of ethanol on hepatic disease development and progression. This study demonstrates silibinin, a biologically active flavanoid derived from milk thistle, inhibits cytochrome p4502E1 induction, ethanol metabolism and reactive oxygen species generation in HCC cells in vitro. These silibinin-mediated effects also inhibit ethanol-dependent increases in HCC cell proliferation in culture.

Keywords: Hepatocellular carcinoma, Ethanol, Cytochrome P4502E1, Oxidative stress, Mitogenesis

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0304-3835(09)00626-0

doi:10.1016/j.canlet.2009.10.004

Cancer Letters
Volume 291, Issue 1 , Pages 120-129, 1 May 2010

Article Tools

* Image Usage & Resolution