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Cancer Letters
Volume 291, Issue 1
, Pages 90-98
, 1 May 2010
Downregulation of nuclear factor-κB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer
References
- . Treatment of pancreatic cancer: challenge of the facts. World J. Surg. 2003;27:1075–1084
- . Cetuximab plus Gemcitabine/oxaliplatin (GEMOXCET) in first-line metastatic pancreatic cancer: a multicentre phase II study. Br. J. Cancer. 2009;100:1032
- . Swiss Group for Clinical Cancer Research; Central European Cooperative Oncology Group, Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J. Clin. Oncol. 2007;25:2212–2217
- . Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res. 2009;69:2400–2407
- . Determinants of resistance to 2’,2’-difluorodeoxycytidine (gemcitabine). Drug Resist. Updat. 2002;5:19–33
- . Beyond IkappaBs: alternative regulation of NF-κB activity. FASEB J. 2007;21:2642–2654
- . Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells. Clin. Cancer. Res. 2008;14:8143–8151
- . NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene. 2003;22:90–97
- . NF-kappaB activity blockade impairs the angiogenic potential of human pancreatic cancer cells. Int. J. Cancer. 2004;108:181–188
- . The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin. Cancer. Res. 1999;5:119–127
- . Mitogenic and antiapoptotic role of constitutive NF-κB/Rel activity in pancreatic cancer. Int. J. Cancer. 2003;105:735–746
- . Increased expression of NF-κB subunits in human pancreaticcancer cells. J. Surg. Res. 2004;118:9–14
- . Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology. 2002;123:2052–2063
- . Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 2001;107:135–142
- . Induction of carcinoma cell migration on vitronectin by NF-kappaB-dependent gene expression. Mol. Biol. Cell. 1995;6:841–850
- . Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene. 2003;22:3243–3251
- . NF-kappaB as a molecular target in the therapy of pancreatic carcinoma. Recent Results Cancer Res. 2008;177:151–164
- . NF-κB as a target for cancer therapy. Expert. Opin. Ther. Targets. 2007;11:133–144
- . Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res. 2005;65:9064–9072
- . Usage of the NF-kappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer. Int. J. Cancer. 2003;104:469–476
- . Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res. 2007;67:3853–3861
- . Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappa B activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy. BMC. Cancer. 2009;9:132
- . Double-stranded RNA as a template for gene silencing. Cell. 2000;101:235–238
- . Enhanced chemosensitivity to irinotecan by RNA interference mediated down-regulation of the nuclear factor-κB p65 subunit. Clin. Cancer Res. 2004;10:3333–3341
- . A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 1991;19:2499
- . Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. Anticancer Drugs. 2009;20:131–140
- . Complete eradication of hepatocellular carcinomas by combined vasostatin gene therapy and B7H3-mediated immunotherapy. J. Hepatol. 2007;46:98–106
- . Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice. Carcinogenesis. 2007;28:1217–1223
- . Two hour exposure to sodium butyrate sensitizes bladder cancer to anticancer drugs. Int. J. Urol. 2008;15:435–441
- . Quantitative analysis of dose–effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul. 1984;22:27–55
- . Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat. Rev. Drug. Discov. 2009;8:33–40
- . Chemoresistance: impact of nuclear factor (NF)-kappaB inhibition by small interfering RNA. Clin. Cancer Res. 2004;10:3262–3264
- . GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy. Cell. Signal. 2008;20:581–589
- . Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Res. 1997;57:1634–1637
- . Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. Oncology. 1998;55:363–369
- . Experimental study of combination therapy with S-1 against pancreatic cancer. Cancer Chemother. Pharmacol. 2009;64:1211–1219
- . Schedule-dependent synergistic interaction between gemcitabine and oxaliplatin in human gallbladder adenocarcinoma cell lines. Anticancer Drugs. 2009;20:123–130
- . BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ. 2006;13:1339–1350
- . Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 1997;275:1129–1132
- . Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: an experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy. Oncol. Rep. 2009;22:105–113
- . Gene transfer of endostatin enhances the efficacy of doxorubicin to suppress human hepatocellular carcinomas in mice. Cancer Sci. 2007;98:1381–1387
- . Antisense hypoxia-inducible factor 1 α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinomas. Cancer Sci. 2008;99:2055–2061
- . Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res. 2002;62:6938–6943
- . NF-κB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J. Biol. Chem. 2000;275:6421–6427
- . The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol. Cell. Biol. 2002;22:8175–8183
- . Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappa B activation. Mol. Endocrinol. 2006;20:1867–1879
- . NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells. J. Biol. Chem. 2001;276:48921–48929
- . The function of multiple IkappaB: NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. Oncogene. 2002;21:6510–6519
PII: S0304-3835(09)00622-3
doi: 10.1016/j.canlet.2009.10.001
© 2009 Elsevier Ireland Ltd. All rights reserved.
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Cancer Letters
Volume 291, Issue 1
, Pages 90-98
, 1 May 2010
