« Previous
Next »
Cancer Letters
Volume 291, Issue 1
, Pages 59-66
, 1 May 2010
Epithelial–mesenchymal transition in ovarian cancer
References
- . Carcinoma invasion and metastasis: a role for epithelial–mesenchymal transition?. Cancer Res. 2005;65:5991–5995
- . Physiological mechanisms of tumor-cell invasion and migration. Physiology. 2005;20:194–200
- . Focus on epithelial ovarian cancer. Cancer Cell. 2004;5:19–24
- . Pathology and classification of ovarian tumors. Cancer. 2003;97:2631–2642
- . Ovarian surface epithelium: biology, endocrinology and pathology. Endocr. Rev. 2001;22:255–288
- . Mesenchymal to epithelial transition in the human ovarian surface epithelium focusing on inclusion cysts. Oncol. Rep. 2009;21:1209–1214
- . Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer. 2003;3:362–374
- . Ovarian cancer metastasis: integrating insights from disparate model organisms. Nat. Rev. Cancer. 2005;5:355–366
- . Epithelial–mesenchymal transition. J. Cell. Sci. 2005;118:4325–4326
- . Complex networks orchestrate epithelial–mesenchymal transitions. Nat. Rev. Mol. Cell. Biol. 2006;7:131–142
- . Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat. Rev. Cancer. 2004;4:118–132
- . Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta. 1994;1198:11–26
- . Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am. J. Pathol. 1993;142:987–993
- . E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex. Gastroenterology. 2009;137:361–371
- . Loss of E-cadherin and cytoplasmic–nuclear expression of β-catenin are the most useful immunoprofiles in the diagnosis of solid–pseudopapillary neoplasm of the pancreas. Hum. Pathol. 2008;39:251–258
- . Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis. Cancer Sci. 2008;99:1933–1939
- . Loss of E-cadherin promotes ovarian cancer metastasis via α5-integrin, which is a therapeutic target. Cancer Res. 2008;68:2329–2339
- . The morphogenic function of E-cadherin-mediated adherens junctions in epithelial ovarian carcinoma formation and progression. Differentiation. 2008;76:193–205
- . E-cadherin expression in human epithelial ovarian cancer and normal ovary. Int. J. Cancer. 1997;74:275–280
- . E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. Proc. Natl. Acad. Sci. USA. 1999;96:6249–6254
- . Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases. Hum. Pathol. 1997;28:922–928
- . Immunohistochemical study of the expression of adhesion molecules in ovarian serous neoplasms. Pathol. Int. 2006;62–70
- . Differential expression of the cell–cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells. Int. J. Cancer. 1994;58:393–399
- . The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell. Biol. 2000;2:84–89
- . The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J. Cell. Sci. 2003;116:499–511
- . The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell. 2001;7:1267–1278
- . Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am. J. Pathol. 2003;163:1437–1447
- . Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1 and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression. Med. Mol. Morphol. 2009;42:82–91
- . New class of transforming growth factors potentiated by epidermal growth factor: Isolation from non-neoplastic tissues. Proc. Natl. Acad. Sci. USA. 1981;78:5339–5343
- . TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 2001;29:117–129
- . TGF-β signal transduction. Annu. Rev. Biochem. 1998;67:753–791
- . Non-Smad pathways in TGF-β signalling. Cell. Res. 2009;19:128–139
- . In situ analysis of transforming growth factors-β (TGF-β1, TGF-β2, TGF-β3) and TGF-β type II receptor expression in basal cell carcinomas. Br. J. Dermatol. 1996;134:1044–1051
- . In situ analysis of transforming growth factor-βs (TGF-β1, TGF-β2, TGF-β3), and TGF-β type II receptor expression in malignant melanoma. Carcinogenesis. 1995;16:1499–1503
- . High levels of transforming growth factor β1 in patients with colorectal cancer: association with disease progression. Gastroenterology. 1996;110:375–382
- . Overexpression of latent transforming growth factor-β1 (TGF-β1) binding protein 1 (LTBP-1) in association with TGF-β1 in ovarian carcinoma. Jpn. J. Cancer Res. 2001;92:506–515
- . Immunolocalizations of VEGF, its receptors flt-1, KDR and TGF-β’s in epithelial ovarian tumors. Histol. Histopathol. 2006;21:1055–1064
- . Transforming growth factor-β and ovarian carcinoma cells: regulation of proliferation and surface antigen expression. Cancer Lett. 1990;51:221–225
- . Growth regulation of ovarian cancer cells by epidermal growth factor and transforming growth factors α and β1. Biochim. Biophys. Acta. 1992;1180:130–136
- . Transforming growth factor β1 (TGF-β1) inhibits growth of a human ovarian carcinoma cell line (OVCCR1) and is expressed in human ovarian tumors. Int. J. Cancer. 1992;52:766–770
- . Ovarian carcinoma cell cultures are resistant to TGF-β1-mediated growth inhibition despite expression of functional receptors. Gynecol. Oncol. 1999;75:72–77
- . TGF β-induced Smad signaling remains intact in primary human ovarian cancer cells. Endocrinology. 2002;143:1174–1181
- . Loss of c-myc repression coincides with ovarian cancer resistance to transforming growth factor β growth arrest independent of transforming growth factor β/Smad signalling. Cancer Res. 2003;63:1413–1419
- . Repression of p15INK4b expression by Myc through association with Miz-1. Nat. Cell. Biol. 2001;3:392–399
- . Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-β signaling in ovarian cancer. Cancer Res. 2006;66:8404–8412
- . EGFR and steroid receptors in ovarian carcinoma: comparison with prognostic parameters and outcome of patients. Anticancer Res. 1997;17:613–619
- . TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell. Biol. 1994;127:2021–2036
- . Epithelial–mesenchymal transformation of a newly established cell line from ovarian adenosarcoma by transforming growth factor-β1. Int. J. Cancer. 1996;66:91–97
- . TGF-(β) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J. Cell. Sci. 1999;112:4557–4568
- . Differential protein expression profiling by iTRAQ–2DLC–MS/MS of lung cancer cells undergoing epithelial–mesenchymal transition reveals a migratory/invasive phenotype. J. Proteome Res. 2006;5:1143–1154
- . Temporal quantitative proteomics by iTRAQ 2D-LC–MS/MS and corresponding mRNA expression analysis identify post-transcriptional modulation of actin-cytoskeleton regulators during TGF-β-Induced epithelial–mesenchymal transition. J. Proteome Res. 2009;8:35–47
- . TGF-β1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell. 1996;86:531–542
- . The prognostic value of epidermal growth factor receptor mRNA expression in primary ovarian cancer. Br. J. Cancer. 1996;73:301–316
- . Tyrosine kinase inhibitors – small molecular weight compounds inhibiting EGFR. Curr. Opin. Mol. Ther. 2009;11:308–321
- . Cetuximab, its clinical use and future perspectives. Anticancer Drugs. 2008;19:99–113
- . Development of TGF-β signalling inhibitors for cancer therapy. Nat. Rev. Drug Discov. 2004;3:1011–1022
- . Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium. Am. J. Physiol. Cell. Physiol. 2006;290:1532–1542
- . Neutrophil gelatinase-associated lipocalin (NGAL) an early-screening biomarker for ovarian cancer: NGAL is associated with epidermal growth factor-induced epithelio-mesenchymal transition. Int. J. Cancer. 2007;120:2426–2434
- . Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of α6 and β1 integrin. Int. J. Biochem. Cell. Biol. 2009;41:1034–1045
- . Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas. Br. J. Cancer. 2009;100:134–144
- . Hepatocyte growth factor (HGF) in ovarian epithelial tumour fluids stimulates the migration of ovarian carcinoma cells. Int. J. Cancer. 1999;83:476–480
- . Overexpression of the Met/HGF receptor in ovarian cancer. Int. J. Cancer. 1994;58:658–662
- . Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation. Exp. Cell. Res. 2004;299:248–256
- . Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells. Endocrinology. 2006;147:2557–2566
- . p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells. Cancer Res. 2008;68:6524–6532
- . Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene. 2003;22:484–497
- . A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411–415
- . Endothelin-1: a multifunctional molecule in cancer. Br. J. Cancer. 2003;88:163–166
- . Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth. Cancer Res. 1999;59:720–727
- . Role of endothelin-1 in neovascularization of ovarian carcinoma. Am. J. Pathos. 2000;157:1537–1547
- . Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor. J. Cardiovasc. Pharmacol. 2004;44:140–143
- . Endothelin-1 promotes epithelial–mesenchymal transition in human ovarian cancer cells. Cancer Res. 2005;65:11649–11657
- . The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle. Reprod. Biol. Endocrinol. 2003;5:9
- . Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells. Endocrinology. 2003;144:3306–3314
- . Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors. Clin. Cancer Res. 2003;9:779–785
- . BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. Carcinogenesis. 2007;28:1153–1162
- . The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res. 2005;65:5996–6000
- . Epithelial–mesenchymal transition. Cancer Res. 2008;68:9574–9577
- . The epithelial–mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704–715
- . Generation of breast cancer stem cells through epithelial–mesenchymal transition. PLoS One. 2008;3:2888
- . Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res. 2009;69:2887–2895
- . Snail and Slug mediate radio- and chemo-resistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells. 2009;27:2059–2068
- . Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am. J. Pathol. 2004;164:1511–1518
PII: S0304-3835(09)00616-8
doi: 10.1016/j.canlet.2009.09.017
© 2009 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Cancer Letters
Volume 291, Issue 1
, Pages 59-66
, 1 May 2010
