Cancer Letters
Volume 290, Issue 2 , Pages 211-215 , 28 April 2010

Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors

  • Masaru Saito

      Affiliations

    • Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
    • Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
    • ,
  • Takahiro Yaguchi

      Affiliations

    • Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
    • ,
  • Yoshiyuki Yasuda

      Affiliations

    • Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
    • Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
    • ,
  • Takashi Nakano

      Affiliations

    • Department of Thoracic Oncology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
    • ,
  • Tomoyuki Nishizaki

      Affiliations

    • Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 798 45 6397; fax: +81 798 45 6649.

Received 29 July 2009 ,Revised 15 September 2009 ,Accepted 15 September 2009.

References 

  1. Saitoh M, Nagai K, Nakagawa K, Yamamura T, Yamamoto S, Nishizaki T. Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem. Pharmacol. 1994;67:2005–2011
  2. Yang D, Yaguchi T, Yamamoto H, Nishizaki T. Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation. Biochem. Pharmacol. 2007;73:1665–1675
  3. Vintermyr OK, Gjertsen BT, Lanotte M, Doskeland SO. Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells. Exp. Cell Res. 1993;206:157–161
  4. Boe R, Gjertsen BT, Doskeland SO, Vintermyr OK. 8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line. Br. J. Cancer. 1995;72:1151–1159
  5. Pratt RM, Martin GR. Epithelial cell death and cyclic AMP increase during palatal development. Proc. Natl. Acad. Sci. USA. 1975;72:874–877
  6. Kim SJ, Min HY, Chung HJ, Park EJ, Hong JY, Kang YJ, et al. Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells. Cancer Lett. 2008;264:309–315
  7. Panjehpour M, Karami-Tehrani F. Adenosine modulates cell growth in the human breast cancer cells via adenosine receptors. Oncol. Res. 2007;16:575–585
  8. Bar-Yehuda S, Stemmer SM, Madi L, Castel D, Ochaion A, Cohen S, et al. The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-kappaB signal transduction pathways. Int. J. Oncol. 2008;33:287–295
  9. S. Morello, R. Sorrentino, A. Porta, G. Forte, A. Popolo, A. Petrella, A. Pinto, Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-κB signalling pathway in thyroid cancer cells, J. Cell. Physiol., in press.
  10. Sai K, Yang D, Yamamoto H, Fujikawa H, Yamamoto S, Nagata T, et al. A1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death. Neurotoxicology. 2006;27:458–467
  11. Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T. Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A2a adenosine receptors. J. Gastroenterol. 2009;44:56–65
  12. Thorburn A. Death receptor-induced cell killing. Cell. Signal. 2004;16:139–144
  13. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 1999;68:383–424

PII: S0304-3835(09)00599-0

doi: 10.1016/j.canlet.2009.09.011

Cancer Letters
Volume 290, Issue 2 , Pages 211-215 , 28 April 2010

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