Cancer Letters
Volume 290, Issue 2 , Pages 182-191, 28 April 2010

Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation

  • Zhongzheng Lu

      Affiliations

    • Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510089, People’s Republic of China
    • ,
  • Yanli Jin

      Affiliations

    • Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510089, People’s Republic of China
    • ,
  • Lin Qiu

      Affiliations

    • Harbin Institute of Hematology and Oncology, Harbin, People’s Republic of China
    • ,
  • Yingrong Lai

      Affiliations

    • Department of Pathology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510089, People’s Republic of China
    • ,
  • Jingxuan Pan

      Affiliations

    • Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510089, People’s Republic of China
    • Corresponding Author InformationCorresponding author. Tel./fax: +86 20 8733 2788.

Received 10 July 2009; received in revised form 5 September 2009; accepted 7 September 2009. published online 12 October 2009.

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PII: S0304-3835(09)00573-4

doi:10.1016/j.canlet.2009.09.006

Cancer Letters
Volume 290, Issue 2 , Pages 182-191, 28 April 2010

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