Cancer Letters
Volume 290, Issue 2 , Pages 167-173, 28 April 2010

Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells

  • Elizabeth W. LaPensee

      Affiliations

    • Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45267, USA
    • ,
  • Christopher R. LaPensee

      Affiliations

    • Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45267, USA
    • ,
  • Sejal Fox

      Affiliations

    • Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45267, USA
    • ,
  • Sandy Schwemberger

      Affiliations

    • Shriners Burns Institute, University of Cincinnati, Cincinnati, OH 45267, USA
    • ,
  • Scott Afton

      Affiliations

    • Department of Chemistry, University of Cincinnati, Cincinnati, OH 45267, USA
    • ,
  • Nira Ben-Jonathan

      Affiliations

    • Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45267, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Cancer and Cell Biology, University of Cincinnati, 3125 Eden Ave, Cincinnati, OH 45267-0521, USA. Tel.: +1 513 558 4821; fax: +1 513 558 4823.

Received 13 July 2009; accepted 7 September 2009. published online 05 October 2009.

Abstract 

Resistance to chemotherapy is a major problem facing breast cancer patients. Cisplatin, a highly effective DNA-damaging drug, has shown only little success in breast cancer treatment. We are reporting that low nanomolar doses of bisphenol A (BPA) or estradiol antagonize cisplatin cytotoxicity in breast cancer cells, with their effects not mediated via classical estrogen receptors. Although both compounds increase the expression of Bcl-2, a Bcl-2 inhibitor completely blocked the protective effects of BPA while only partially affecting those of estradiol. Blockade of BPA and E2 actions should sensitize ER-negative breast tumors to anti-cancer drugs and allow for the inclusion of cisplatin in treatment regimens.

Keywords: Breast cancer cells, Cisplatin, Bisphenol A, Estradiol, Estrogen receptors, Bcl-2

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PII: S0304-3835(09)00572-2

doi:10.1016/j.canlet.2009.09.005

Cancer Letters
Volume 290, Issue 2 , Pages 167-173, 28 April 2010

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