Cancer Letters
Volume 290, Issue 2 , Pages 139-147, 28 April 2010

An epitome of DNA repair related genes and mechanisms in thyroid carcinoma

  • Elisavet Gatzidou

      Affiliations

    • Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
    • ,
  • Christina Michailidi

      Affiliations

    • Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
    • ,
  • Sophia Tseleni-Balafouta

      Affiliations

    • Department of Pathology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
    • ,
  • Stamatios Theocharis

      Affiliations

    • Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
    • Corresponding Author InformationCorresponding author.

Received 10 May 2009; received in revised form 31 July 2009; accepted 2 August 2009. published online 26 August 2009.

Abstract 

Thyroid cancer presents a growing tendency during the last decades, particularly in regions affected by radiation exposure. The present review describes expression alterations and gene polymorphisms of DNA repair related molecules, leading to genomic instability and cell death, being associated with thyroid cancer. The referred variations in DNA repair related genes depict that indirect repair mechanisms are mainly correlated with thyroid gland carcinogenesis. Such abnormalities could participate in thyroid tumor development and progression and could be targeted for future prevention and therapy.

Keywords: Thyroid cancer, DNA repair systems, Gene polymorphisms, Cancer predisposition

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PII: S0304-3835(09)00523-0

doi:10.1016/j.canlet.2009.08.007

Cancer Letters
Volume 290, Issue 2 , Pages 139-147, 28 April 2010

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