Cancer Letters
Volume 286, Issue 2 , Pages 250-259, 28 December 2009

Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells

  • Chia-Li Kao

      Affiliations

    • Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan, Republic of China
    • Contributed equally to this work.
    • ,
  • Han-Shui Hsu

      Affiliations

    • Institute of Emergency and Critical Care Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China
    • Contributed equally to this work.
    • ,
  • Hsin-Wu Chen

      Affiliations

    • Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan, Republic of China
    • Contributed equally to this work.
    • ,
  • Tzu-Hao Cheng

      Affiliations

    • Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan, Republic of China
    • Corresponding Author InformationCorresponding author. Tel.: +886 2 28267331; fax: +886 2 28264843.

Received 18 March 2009; received in revised form 21 May 2009; accepted 29 May 2009. published online 29 June 2009.

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PII: S0304-3835(09)00397-8

doi:10.1016/j.canlet.2009.05.031

Cancer Letters
Volume 286, Issue 2 , Pages 250-259, 28 December 2009

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