Cancer Letters
Volume 286, Issue 2 , Pages 172-179 , 28 December 2009

Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells

  • Dong-Oh Moon

      Affiliations

    • Department of Marine Life Science, Jeju National University and Jeju Regional Cancer Center, Jeju 690-756, Republic of Korea
    • ,
  • Mun-Ock Kim

      Affiliations

    • Department of Marine Life Science, Jeju National University and Jeju Regional Cancer Center, Jeju 690-756, Republic of Korea
    • ,
  • Jae-Dong Lee

      Affiliations

    • Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea
    • ,
  • Yung Hyun Choi

      Affiliations

    • Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614-054, Republic of Korea
    • ,
  • Gi-Young Kim

      Affiliations

    • Department of Marine Life Science, Jeju National University and Jeju Regional Cancer Center, Jeju 690-756, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 64 754 3427; fax: +82 64 756 3493.

Received 5 December 2008 ,Revised 12 May 2009 ,Accepted 25 May 2009.

References 

  1. Greider CW. Telomere length regulation. Annu. Rev. Biochem. 1996;65:337–365
  2. Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem?. Science. 1995;269:1533–1534
  3. Harley CB. Telomere loss: mitotic clock or genetic time bomb?. Mutat. Res. 1991;256:271–282
  4. Blackburn EH. Telomerases. Annu. Rev. Biochem. 1992;61:113–129
  5. Xu D, Gruber A, Björkholm M, Peterson C, Pisa P. Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms. Br. J. Cancer. 1999;80:1156–1161
  6. Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat. Genet. 1999;21:115–118
  7. Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat. Med. 1999;5:1164–1170
  8. Delhommeau F, Thierry A, Feneux D, Lauret E, Leclercq E, Courtier MH, et al. Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant. Oncogene. 2002;21:8262–8271
  9. Ramakrishnan S, Eppenberger U, Mueller H, Shinkai Y, Narayanan R. Expression profile of the putative catalytic subunit of the telomerase gene. Cancer Res. 1998;58:622–625
  10. Wang Z, Kyo S, Takakura M, Tanaka M, Yatabe N, Maida Y, et al. Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway. Cancer Res. 2000;60:5367–5381
  11. Henderson YC, Breau RL, Liu TJ, Clayman GL. Telomerase activity in head and neck tumors after introduction of wild-type p53, p21, p16, and E2F-1 genes by means of recombinant adenovirus. Head Neck. 2000;22:347–354
  12. Hao H, Nancai Y, Lei F, Xiong W, Wen S, Guofu H, et al. siRNA directed against c-Myc inhibits proliferation and downregulates human telomerase reverse transcriptase in human colon cancer Colo 320 cells. J. Exp. Clin. Cancer Res. 2008;12:27
  13. Kang SS, Kwon T, Kwon DY, Do SI. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 1999;274:13085–13090
  14. Kim NY, Pae HO, Oh GS, Kang TH, Kim YC, Rhew HY, et al. Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol. Toxicol. 2001;88:261–266
  15. Iwashita K, Kobori M, Yamaki K, Tsushida T. Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci. Biotechnol. Biochem. 2000;64:1813–1820
  16. Kim N. Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). Arch. Pharm. Res. 2008;31:1179–1186
  17. Yeo M, Rha SY, Jeung HC, Hu SX, Yang SH, Kim YS, et al. Attenuation of telomerase activity by hammerhead ribozyme targeting human telomerase RNA induces growth retardation and apoptosis in human breast tumor cells. Int. J. Cancer. 2005;114:484–489
  18. Veldman T, Liu X, Yuan H, Schlegel R. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc. Natl. Acad. Sci. USA. 2003;100:8211–8216
  19. Pendino F, Flexor M, Delhommeau F, Buet D, Lanotte M, Segal-Bendirdjian E. Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation. Proc. Natl. Acad. Sci. USA. 2001;98:6662–6667
  20. Pandey MK, Sandur SK, Sung B, Sethi G, Kunnumakkara AB, Aggarwal BB. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. J. Biol. Chem. 2007;282:17340–17350
  21. Jagadeesh S, Kyo S, Banerjee PP. Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res. 2006;66:2107–2115
  22. Ghosh U, Bhattacharyya NP. Benzamide and 4-amino 1,8 naphthalimide treatment inhibit telomerase activity by down-regulating the expression of telomerase associated protein and inhibiting the poly(ADP-ribosyl)ation of telomerase reverse transcriptase in cultured cells. FEBS J. 2005;272:4237–4248
  23. Horikawa I, Barrett JC. Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Carcinogenesis. 2003;24:1167–1176
  24. Matsubara Y, Murata M, Yoshida T, Watanabe K, Saito I, Miyaki K, et al. Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT. Biochem. Biophys. Res. Commun. 2006;341:128–131
  25. Cong YS, Wen J, Bacchetti S. The human telomerase catalytic subunit in hTERT: organization of the gene and characterization of the promoter. Hum. Mol. Genet. 1999;8:137–142
  26. Kyo S, Takakura M, Taira T, Kanaya T, Itoh H, Yutsudo M, et al. Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. 2000;28:669–677
  27. Akiyama M, Hideshima T, Hayashi T, Tai YT, Mitsiades CS, Mitsiades N, et al. Nuclear factor-(B p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res. 2003;63:18–21
  28. Kim YW, Hur SY, Kim TE, Lee JM, Namkoong SE, Ki IK, et al. Protein kinase C modulates telomerase activity in human cervical cancer cells. Exp. Mol. Med. 2001;33:156–163
  29. Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K, et al. Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J. 2000;19:2652–2661

PII: S0304-3835(09)00382-6

doi: 10.1016/j.canlet.2009.05.028

Cancer Letters
Volume 286, Issue 2 , Pages 172-179 , 28 December 2009

Article Tools

* Image Usage & Resolution