MKP1 repression is required for the chemosensitizing effects of NF-κB and PI3K inhibitors to cisplatin in non-small cell lung cancer

Cortes-Sempere, María; Chattopadhyay, Sharmila; Rovira, Ana; Rodriguez-Fanjul, Vanessa; Belda-Iniesta, Cristobal; Tapia, Marian; Cejas, Paloma; Machado-Pinilla, Rosario; Manguan-García, Cristina; Sánchez-Pérez, Isabel; Nistal, Manuel; Moratilla, Carmen; Castro-Carpeño, Javier de; Gonzalez-Barón, Manuel; Albanell, Joan; Perona, Rosario

doi:10.1016/j.canlet.2009.05.029

« Previous Next »Cancer Letters
Volume 286, Issue 2 , Pages 206-216, 28 December 2009

MKP1 repression is required for the chemosensitizing effects of NF-κB and PI3K inhibitors to cisplatin in non-small cell lung cancer

María Cortes-Sempere
- Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain
- CIBER de Enfermedades Raras (CIBERER) Valencia, C/Álvaro de Bazán, 10 Valencia, Spain
- These authors contributed equally to this manuscript.
Sharmila Chattopadhyay
- Department of Pathology, University of California, San Diego, CA, United States
- These authors contributed equally to this manuscript.
Ana Rovira
- Medical Oncology Department, Hospital del Mar-IMAS, Barcelona, Spain
- Cancer Research Program, IMIM-Hospital del Mar, PRBB, Barcelona, Spain
Vanessa Rodriguez-Fanjul
- Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain
- CIBER de Enfermedades Raras (CIBERER) Valencia, C/Álvaro de Bazán, 10 Valencia, Spain
Cristobal Belda-Iniesta
- Medical Oncology Department, Hospital La Paz, Madrid, Spain
Marian Tapia
- Medical Oncology Department, Hospital del Mar-IMAS, Barcelona, Spain
- Cancer Research Program, IMIM-Hospital del Mar, PRBB, Barcelona, Spain
Paloma Cejas
- Medical Oncology Department, Hospital La Paz, Madrid, Spain
Rosario Machado-Pinilla
- Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain
- CIBER de Enfermedades Raras (CIBERER) Valencia, C/Álvaro de Bazán, 10 Valencia, Spain
Cristina Manguan-García
- Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain
- CIBER de Enfermedades Raras (CIBERER) Valencia, C/Álvaro de Bazán, 10 Valencia, Spain
Isabel Sánchez-Pérez
- Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain
- CIBER de Enfermedades Raras (CIBERER) Valencia, C/Álvaro de Bazán, 10 Valencia, Spain
Manuel Nistal
- Pathology Department Hospital La Paz, Madrid, Spain
Carmen Moratilla
- Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain
Javier de Castro-Carpeño
- Medical Oncology Department, Hospital La Paz, Madrid, Spain
Manuel Gonzalez-Barón
- Medical Oncology Department, Hospital La Paz, Madrid, Spain
Joan Albanell
- Medical Oncology Department, Hospital del Mar-IMAS, Barcelona, Spain
- Cancer Research Program, IMIM-Hospital del Mar, PRBB, Barcelona, Spain
Rosario Perona
- Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain
- CIBER de Enfermedades Raras (CIBERER) Valencia, C/Álvaro de Bazán, 10 Valencia, Spain
- Corresponding author. Address: Translational Oncology Unit C.S.I.C./U.A.M: Instituto de Investigaciones Biomédicas C.S.I.C./U.A.M., C/Arturo Duperier, 4, Madrid 28029, Spain. Tel.: +34 91 5854463; fax: +34 91 5854401.