« Previous
Next »
Cancer Letters
Volume 284, Issue 1
, Pages 7-14
, 18 October 2009
Janus kinase 2 mutations in Philadelphia negative chronic myeloproliferative disorders: Clinical implications
References
- . Myeloproliferative disorders. Best Pract. Res. Clin. Haematol. 2001;14:531–551
- . Polycythemia vera: a comprehensive review and clinical recommendations. Mayo Clin. Proc. 2003;78:174–194
- . Chronic myeloproliferative disorders with thrombocythemia: a comparative study of two classification systems (PVSG, WHO) on 839 patients. Ann. Hematol. 2003;82:148–152
- . Diagnostic criteria and prognosis in polycythemia vera and essential thrombocythemia. Semin. Hematol. 1999;36:9–13
- . Polycythemia vera: myths, mechanisms and management. Blood. 2002;100:4272–4290
- . The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100:2292–2302
- . Classic and atypical myeloproliferative disorders. Best Pract. Res. Clin. Haematol. 2006;19:361–364
- . Identification of an acquired JAK2 mutation in polycythemia vera. J. Biol. Chem. 2005;280:22788–22792
- Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365:1054–1061
- Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7:387–397
- . A unique clonal JAK2 mutation leading to constitutive signaling causes polycythemia vera. Nature. 2005;434:1144–1148
- . A gain of function mutation in JAK2 is frequently found in patients with myeloproliferative disorders. New Engl. J. Med. 2005;352:1779–1790
- . JAK2 mutations and clinical practice in myeloproliferative neoplasms. Cancer J. 2007;13:366–371
- . JAK and MPL mutations in myeloid malignancies. Lukemia Lymphoma. 2008;49:388–397
- . The role of Janus kinases in haemopoiesis and haematological malignancy. Br. J. Haematol. 2006;134:366–384
- Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. 2005;106:2162–2168
- . The JAK2V617F mutation is detectable at very low level in peripheral blood of healthy donors. Leukemia. 2006;20:1622
- . Validity test study of JAK2V617F and allele burden quantification in the diagnosis of myeloproliferative diseases. Ann. Hematol. 2008;87:741–749
- . New insights into the pathogenesis and drug treatment of myelofibrosis. Curr. Opin. Hematol. 2006;13:87–92
- The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera. Blood. 2007;110:1013–1021
- . Expression of JAK2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood. 2006;107:4274–4281
- Characterization of murine JAKV617F positive myeloproliferative disease. Cancer Res. 2006;66:11156–11165
- . Classification of chronic myeloid disorders: from Dameshec towards a semi-molecular system. Best Pract. Res. Clin. Haematol. 2006;19:365–385
- . Polycythemia vera and molecular basis: an update. Best Pract. Res. Clin. Haematol. 2006;19:387–397
- . The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes. Blood. 2005;106:1207–1209
- The JAK2 V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood. 2005;106:3377–3379
- JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia. Leukemia. 2005;19:1843–1844
- The JAK2 V617F mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood. 2005;106:2920–2921
- . The V617F mutation in JAK2 is not found in childhood acute lymphoblastic leukemia. Br. J. Haematol. 2005;130:964–972
- . JAK2 V617F mutation is uncommon in chronic myelomonocytic leukemia. Br. J. Haematol. 2005;130:968
- . Role of the JAK2 mutation in the diagnosis of chronic myeloproliferative disorders in splanchnic vein thrombosis. Hepatology. 2006;44:1528–1534
- Prevalence of the activating JAK2 tyrosine kinase mutation in the Budd-Chiari syndrome. Gastroenterology. 2006;130:2031–2038
- JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. New Engl. J. Med. 2007;356:459–468
- . Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia. 2007;21:1960–1963
- . The frequency of JAK2 exon 12 mutations in idiopathic erythrocytosis patients with low serum erythropoietin levels. Haematologica. 2007;92:1585–1589
- . Clonal heterogeneity in polycythemia vera patients with JAK2 exon 12 and JAK2V617F mutations. Blood. 2008;111:3863–3866
- . JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia Lymphoma. 2008;49:586–588
- Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia and primary myelofibrosis: recombinations from an ad hoc international expert panel. Blood. 2007;110:1092–1097
- . Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008;22:14–22
- . JAK2 and MPL mutations in myeloproliferative neoplasms: discovery and science. Leukemia. 2008;22:1813–1817
- . Genetic complexity of myeloproliferative neoplasms. Leukemia. 2008;22:1841–1848
- . Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal. Leukemia. 2008;22:1299–1307
- . Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders. Blood. 2008;111:2785–2789
- . Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood. 2006;108:1377–1380
- Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray. Exp. Hematol. 2008;36:1471–1479
- . Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat. Rev. 2007;7:673–683
- . Familial chronic myeloproliferative disorders: the state of the art. Hematol. Oncol. 2008;26:131–138
- JAK2V617F as an acquired somatic mutation and a secondary genetic event associated with disease progression in familial myeloproliferative disorders. Cancer. 2006;107:2206–2211
- . The JAK2V617F mutation is acquired secondary to the predisposing alteration in familial polycythemia vera. Br. J. Haematol. 2005;130:800–801
- Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders. Blood. 2006;108:346–352
- . Increased risks of polycythemia vera essential thrombocythemia and myelofibrosis among 24577 first-degree relatives of 11039 patients with myeloproliferative neoplasms in Sweden. Blood. 2008;112:2199–2204
- . Cytogenetic and molecular aspects of Philadelphia negative chronic myeloproliferative disorders: clinical implications. Cancer Lett. 2007;255:12–25
- . Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. Exp. Hematol. 2002;30:229–236
- Characterization of del20q in peripheral blood of MPD patients using copy number analysis and high resolution oligonucleotide CGH array. Blood. 2007;110:457A–458A
- . Clonal analysis of deletions on chromosome20q and JAK2V617F in MPD suggests that del20q acts independently and is not one of the pre-disposing mutations for JAK2V617F. Blood. 2008;
- Mutation of JAK2 in the myeloproliferative disorders: timing, clonarity studies, cytogenetic associations and role in leukemic transformation. Blood. 2006;108:3548–3555
- Leukemic blasts in transformed JAK2V617F-positive myeloproliferative disorders are frequently negative for the JAK2V617F mutation. Blood. 2007;110:375–379
- . Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia. Blood. 2006;108:2435–2437
- . Identification of JAK2 V617F in patients with polycythemia is highly correlated with conventional criteria for diagnosis of polycythemia vera. Am. J. Hematol. 2007;82:80–82
- . Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera. Leukemia Res. 2007;31:97–101
- . Idiopathic erythocytosis: a declining entity. Br. J. Haematol. 2001;115:774–781
- . JAK2 V617F and leukemic transformation in myelofibrosis with myeloid metaplasia. Leukemia Res. 2006;30:1457–1460
- . JAK2 V617F mutation in leukemic transformation of Philadelphia negative chronic myeloproliferative disorders. Br. J. Haematol. 2006;135:267–268
- Hemizygous/homozygous and heterozygous JAK2 mutation detected in plasma of patients with myeloproliferative diseases: correlation with clinical behaviour. Br. J. Haematol. 2006;134:341–342
- . Correlation of JAK2 V617F mutation with clinical and laboratory findings in patients with myeloproliferative disorders. Leukemia Res. 2007;31:1053–1062
- The JAK2 V617F tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates. Br. J. Haematol. 2005;131:320–328
- Definition of subtypes of essential thrombocythemia and relation to polycythemia vera based on JAK2 V617F mutation status: a prospective study. Lancet. 2005;366:1945–1953
- The clinical phenotype of wild-type, heterozygous and homozygous JAK2V617F in polycythemia vera. Cancer. 2006;106:631–635
- Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia. Blood. 2007;110:840–846
- . MPD Research Consortium, Prospective identification of high-risk polycythemia vera patients based on JAK2V617F allele burden. Leukemia. 2007;21:1952–1959
- . Bone marrow JAK2V617F allele burden and clinical correlates in polycythemia vera. Leukemia. 2007;21:2074–2075
- . Thrombosis in myeloproliferative disorders: Prevalence, prognostic factors and the role of leucocytes and JAK2V617F. Semin. Thromb. Hemost. 2007;33:313–320
- . The presence of JAK2V617F in primary myelofibrosis or its allele burden in polycythemia vera predicts chemosensitivity to hydroxyurea. Am. J. Hematol. 2008;83:363–365
- . Clinical correlates of JAK2V617F allele burden in essential thrombocythemia. Cancer. 2007;109:2279–2284
- . JAK2 V617F mutation in essential thrombocythemia: clinical associations and long-term prognostic relevance. Br. J. Haematol. 2005;131:208–213
- . Clinical implications of the JAK2V617F mutation in essential thrombocythemia. Leukemia. 2005;19:1847–1849
- . The presence of JAK2 V617F mutation is associated with a higher haemoglobin and increased risk of thrombosis in essential thrombocythemia. Br. J. Haematol. 2005;132:244–250
- . JAK2 V617F mutation in platelets from essential thrombocythemia patients: correlation with clinical features and analysis of STAT5 phosphprylation status. Eur. J. Haematol. 2006;77:210–216
- . Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors and JAK2 mutation status. Blood. 2007;109:2310–2313
- . Myeloproliferative Disorders Research Consortium (MPD-RC), Influence of JAK2 V617F allele burden on phenotype in essential thrombocythemia. Haematologica. 2008;93:41–48
- . High prevalence of arterial thrombosis in JAK2 mutated essential thrombocythemia: independence of the V617F allele burden. Hematology. 2008;13:71–76
- V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood. 2006;107:2098–2100
- JAK2V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis. Blood. 2007;110:4030–4036
- . Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia free survival. Leukemia. 2008;22:756–761
- . Essential thrombocythemia, polycythemia vera and myelofibrosis: current management and the prospect of targeted therapy. Am. J. Hematol. 2008;83:491–497
- . JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials. Leukemia. 2008;22:23–30
PII: S0304-3835(09)00088-3
doi: 10.1016/j.canlet.2009.02.010
© 2009 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Cancer Letters
Volume 284, Issue 1
, Pages 7-14
, 18 October 2009
