Cancer Letters
Volume 286, Issue 1 , Pages 52-59, 1 December 2009

Hepatitis B virus induced hepatocellular carcinoma

INSERM, U871, 69003 Lyon, France

Université Lyon 1, IFR62 Lyon-Est, 69008 Lyon, France

Hospices Civils de Lyon, Hôtel Dieu, Service d’hépatologie et de gastroentérologie, 69002 Lyon, France

Received 2 July 2008; received in revised form 21 November 2008; accepted 2 December 2008. published online 15 January 2009.

Abstract 

A number of risk factors appear to play a role in Hepatocellularcinoma (HCC), HBV infection being one of the most important. Chronic inflammation and cytokines are key determinants in the development of fibrosis and liver cell proliferation. HBV DNA integration and/or expression of HBV proteins may have a direct effect on cellular functions. Occult hepatitis B virus infection is characterized by persistence of HBV DNA in hepatitis B surface antigen-negative individuals. There are evidences that occult HBV is a risk factor for the development of HCC and that the potential mechanisms whereby overt HBV might induce tumour formation are mostly maintained.

Keywords: Hepatitis B, Occult infections, Natural history, Hepatocellularcinoma

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PII: S0304-3835(08)00933-6

doi:10.1016/j.canlet.2008.12.003

Cancer Letters
Volume 286, Issue 1 , Pages 52-59, 1 December 2009

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