Cancer Letters
Volume 276, Issue 2 , Pages 189-195 , 18 April 2009

RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion

  • Ye-Hong Kuang

      Affiliations

    • Department of Dermatology, Xiang Ya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, China
    • The State Key Laboratory of Medical Genetics, Institute of Medical Genetics, Central South University, Changsha, Hunan 410008, China
    • ,
  • Xiang Chen

      Affiliations

    • Department of Dermatology, Xiang Ya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, China
    • The State Key Laboratory of Medical Genetics, Institute of Medical Genetics, Central South University, Changsha, Hunan 410008, China
    • Corresponding Author InformationCorresponding author. Address: Department of Dermatology, Xiang Ya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, China. Tel.: +86 731 432 7377; fax: +86 731 432 8478.
    • ,
  • Juan Su

      Affiliations

    • Department of Dermatology, Xiang Ya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, China
    • The State Key Laboratory of Medical Genetics, Institute of Medical Genetics, Central South University, Changsha, Hunan 410008, China
    • ,
  • Li-Sha Wu

      Affiliations

    • Department of Dermatology, Xiang Ya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, China
    • The State Key Laboratory of Medical Genetics, Institute of Medical Genetics, Central South University, Changsha, Hunan 410008, China
    • ,
  • Li-Qiu Liao

      Affiliations

    • Department of General Surgery, Xiang Ya Hospital, Central South University, Hunan, China
    • ,
  • Dai Li

      Affiliations

    • Department of Dermatology, Xiang Ya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, China
    • ,
  • Zhe-Sheng Chen

      Affiliations

    • Department of Pharmaceutical Sciences, St. John’s University, New York, USA
    • ,
  • Takuro Kanekura

      Affiliations

    • Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Received 16 September 2008 ,Revised 30 October 2008 ,Accepted 7 November 2008.

References 

  1. Miyauchi T, Kanekura T, Yamaoka A, Ozawa M, Miyazawa S, Muramatsu T. Basigin, a new, broadly distributed member of the immunoglobulin superfamily, has strong homology with both the immunoglobulin V domain and the beta-chain of major histocompatibility complex class II antigen. J. Biochem. 1990;107:316–323
  2. Kanekura T, Miyauchi T, Tashiro M, Muramatsu T. Basigin, a new member of the immunoglobulin superfamily: genes in different mammalian species, glycosylation changes in the molecule from adult organs and possible variation in the N-terminal sequences. Cell Struct. Funct. 1991;16:23–30
  3. Kanekura T, Chen X, Kanzaki T. Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int. J. Cancer. 2002;99:520–528
  4. Chen X, Lin J, Kanekura T, Su J, Lin W, Xie HF, et al. A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res. 2006;66:11323–11330
  5. Yang JM, Xu Z, Wu H, Zhu H, Wu X, Hait WN. Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol. Cancer Res. 2003;1:420–427
  6. Li QQ, Wang WJ, Xu JD, Cao XX, Chen Q, Yang JM, et al. Up-regulation of CD147 and matrix metalloproteinase-2, -9 induced by P-glycoprotein substrates in multidrug resistant breast cancer cells. Cancer Sci. 2007;98:1767–1774
  7. Li QQ, Wang WJ, Xu JD, Cao XX, Chen Q, Yang JM, et al. Involvement of CD147 in regulation of multidrug resistance to P-gp substrate drugs and in vitro invasion in breast cancer cells. Cancer Sci. 2007;98:1064–1069
  8. Misra S, Ghatak S, Jones Zoltan A, Toole BP. Regulation of multidrug resistance in cancer cells by hyaluronan. J. Biol. Chem. 2003;278:25285–25288
  9. Intasai N, Mai S, Kasinrerk W, Tayapiwatana C. Binding of multivalent CD147 phage induces apoptosis of U937 cells. Int. Immunol. 2006;18:1159–1169
  10. Deveraux QL, Roy N, Stennicke HR. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998;17:2215–2223
  11. Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 1998;58:5315–5320
  12. Danson S, Dean E, Dive C, Ranson M. IAPs as a target for anticancer therapy. Curr. Cancer Drug Targets. 2007;7:785–794
  13. Dean EJ, Ranson M, Blackhall F, Dive C. X-linked inhibitor of apoptosis protein as a therapeutic target. Expert Opin. Ther. Targets. 2007;11:1459–1471
  14. Kuang H, Chen X, Su J, Wu LS, Li J, Chang J, et al. Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. J. Proteome Res. 2008;7:4784–4791
  15. Zou W, Yang H, Hou X, Zhang W, Chen B, Xin X. Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells. Cancer Lett. 2007;248:211–218
  16. Jia L, Wang H, Qu S, Miao X, Zhang J. CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma. IUBMB Life. 2008;60:57–63
  17. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70
  18. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411:342–348
  19. Kaufmann SH, Vaux DL. Alterations in the apoptotic machinery and their potential role in anticancer drug resistance. Oncogene. 2003;22:7414–7430
  20. Asselin E, Mills GB, Tsang BK. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res. 2001;61:1862–1868
  21. Li Y, Jian Z, Xia K, Li X, Lv X, Pei H, et al. XIAP is related to the chemoresistance and inhibited its expression by RNA interference sensitize pancreatic carcinoma cells to chemotherapeutics. Pancreas. 2006;32:288–296
  22. Bilim V, Kasahara T, Hara N, Takahashi K, Tomita Y. Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro. Int. J. Cancer. 2003;103:29–37
  23. Matsumiya T, Imaizumi T, Yoshida H, Kimura H, Satoh K. Cisplatin inhibits the expression of X-chromosome-linked inhibitor of apoptosis protein in an oral carcinoma cell line. Oral Oncol. 2001;37:296–300
  24. Chen X, Su J, Chang J, Kanekura T, Li J, Kuang YH, et al. Inhibition of CD147 gene expression via RNA interference reduces tumor cell proliferation, activation, adhesion, and migration activity in the human Jurkat T-lymphoma cell line. Cancer Invest. 2008;26:689–697
  25. Yang JM, O’Neill P, Jin W, Foty R, Medina DJ, Xu Z, et al. Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J. Biol. Chem. 2006;281:9719–9727
  26. Marieb EA, Zoltan-Jones A, Li R, Misra S, Ghatak S, Cao J, et al. Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res. 2004;64:1229–1232
  27. Warr JR, Bamford A, Quinn DM. The preferential induction of apoptosis in multidrug-resistant KB cells by 5-fluorouracil. Cancer Lett. 2002;175:39–44

PII: S0304-3835(08)00885-9

doi: 10.1016/j.canlet.2008.11.010

Cancer Letters
Volume 276, Issue 2 , Pages 189-195 , 18 April 2009

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