A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma

Zhou, Bin; Rao, Li; Li, Yi; Gao, Linbo; Wang, Yanyun; Chen, Yu; Xue, Hui; Song, Yaping; Peng, Ying; Liao, Miao; Zhang, Lin

doi:10.1016/j.canlet.2008.10.002

« Previous Next »Cancer Letters
Volume 275, Issue 1 , Pages 72-76, 8 March 2009

A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma

Bin Zhou
- Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China
- These authors contributed equally to this work.
Li Rao
- Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, PR China
- These authors contributed equally to this work.
Yi Li
- Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China
Linbo Gao
- Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China
Yanyun Wang
- Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China
Yu Chen
- Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, PR China
Hui Xue
- Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, PR China
Yaping Song
- Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China
Ying Peng
- Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, PR China
Miao Liao
- Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, PR China
Lin Zhang
- Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China
- Corresponding author. Tel.: +86 28 85469033; fax: +86 28 85401825.

Received 30 July 2008; received in revised form 17 September 2008; accepted 2 October 2008. published online 10 November 2008.

Abstract

Nasopharyngeal carcinoma (NPC) is a common malignancy in southern China and Southeast Asia. Nuclear factor-κB (NF-κB)-activation plays critical roles in Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) mediated tumorigenesis in NPC. A functional insertion/deletion polymorphism (−94 insertion/deletion ATTG) in the promoter of NFKB1 gene, which encodes the p50 subunit of NF-κB protein complex, was recently identified. This study found that the frequency of ATTG₂ allele in NPC patients was significantly higher than that in control subjects (66% vs. 57.1%, p=0.015, OR=1.453), suggesting that the functional NFKB1 promoter polymorphism is associated with increased risk for NPC.