Cancer Letters
Volume 275, Issue 1 , Pages 61-71 , 8 March 2009

Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma

  • Eun Jung Kim

      Affiliations

    • Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
  • ,
  • Zhong Min Che

      Affiliations

    • Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
  • ,
  • Young Jin Park

      Affiliations

    • Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
  • ,
  • Young Sun Hwang

      Affiliations

    • Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
  • ,
  • Ki Yeol Kim

      Affiliations

    • Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
  • ,
  • Da Woon Jung

      Affiliations

    • Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
  • ,
  • Nam Kyung Jeon

      Affiliations

    • Electrotechnology Research Institute, Ansan, Republic of Korea
  • ,
  • Young Wook Choi

      Affiliations

    • Electrotechnology Research Institute, Ansan, Republic of Korea
  • ,
  • Eun Ju Lee

      Affiliations

    • Department of Clinical Laboratory Science, Daejeon Health Sciences College, Daejeon, Republic of Korea
  • ,
  • Jin Kim

      Affiliations

    • Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 2228 3031; fax: +82 2 392 2959.

Received 4 August 2008 ,Revised 25 September 2008 ,Accepted 1 October 2008.

References 

  1. Thompson LDR. Squamous cell carcinoma variants of the head and neck. Curr. Diagn. Pathol. 2003;9:384–396
  2. Ellis GL, Langloss JM, Heffner DK, Hyams VJ. Spindle-cell carcinoma of the aerodigestive tract. An immunohistochemical analysis of 21 cases. Am. J. Surg. Pathol. 1987;11:335–342
  3. Zarbo RJ, Crissman JD, Venkat H, Weiss MA. Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immunohistologic and ultrastructural study of 18 biphasic tumors and comparison with seven monophasic spindle-cell tumors. Am. J. Surg. Pathol. 1986;10:741–753
  4. Lichtiger B, Mackay B, Tessmer CF. Spindle-cell variant of squamous carcinoma. A light and electron microscopic study of 13 cases. Cancer. 1970;26:1311–1320
  5. Takata T, Ito H, Ogawa I, Miyauchi M, Ijuhin N, Nikai H. Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. Virchows Arch. A Pathol. Anat. Histopathol. 1991;419:177–182
  6. Battifora H. Spindle cell carcinoma: ultrastructural evidence of squamous origin and collagen production by the tumor cells. Cancer. 1976;37:2275–2282
  7. Ellis GL, Corio RL. Spindle cell carcinoma of the oral cavity. A clinicopathologic assessment of fifty-nine cases. Oral Surg. Oral Med. Oral Pathol. 1980;50:523–533
  8. Kwon MS, Hong SJ, Cho HA, Ahn GH, Lee SS, Lee KY, et al. Extensive and divergent chromosomal losses in squamous and spindle-cell components of esophageal sarcomatoid carcinoma. Virchows Arch. 2003;443:635–642
  9. Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinomas of the breast II. Spindle cell carcinoma. Hum. Pathol. 1989;20:732–740
  10. Choi HR, Sturgis EM, Rosenthal DI, Luna MA, Batsakis JG, El-Naggar AK. Sarcomatoid carcinoma of the head and neck: molecular evidence for evolution and progression from conventional squamous cell carcinomas. Am. J. Surg. Pathol. 2003;27:1216–1220
  11. Torenbeek R, Hermsen MA, Meijer GA, Baak JP, Meijer CJ. Analysis by comparative genomic hybridization of epithelial and spindle cell components in sarcomatoid carcinoma and carcinosarcoma: histogenetic aspects. J. Pathol. 1999;189:338–343
  12. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2000;2:76–83
  13. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer. 2002;2:442–454
  14. Leventon GS, Evans HL. Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck: a clinicopathologic study of 20 cases. Cancer. 1981;48:994–1003
  15. Lewis JE, Olsen KD, Sebo TJ. Spindle cell carcinoma of the larynx: review of 26 cases including DNA content and immunohistochemistry. Hum. Pathol. 1997;28:664–673
  16. Thompson LD, Wieneke JA, Miettinen M, Heffner DK. Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am. J. Surg. Pathol. 2002;26:153–170
  17. Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, Palacios J, et al. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene. 2002;21:3241–3246
  18. Yokoyama K, Kamata N, Fujimoto R, Tsutsumi S, Tomonari M, Taki M, et al. Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int. J. Oncol. 2003;22:891–898
  19. Yokoyama K, Kamata N, Hayashi E, Hoteiya T, Ueda N, Fujimoto R, et al. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol. 2001;37:65–71
  20. Lee EJ, Kim J, Lee SA, Kim EJ, Chun YC, Ryu MH, et al. Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells. Exp. Mol. Med. 2005;37:379–390
  21. Nystrom ML, Thomas GJ, Stone M, Mackenzie IC, Hart IR, Marshall JF. Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J. Pathol. 2005;205:468–475
  22. Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJ, van de Vijver M, Cornelisse C, et al. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J. 1995;14:6107–6115
  23. Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta. 1994;1198:11–26
  24. Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell. 2003;4:499–515
  25. Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat. Rev. Mol. Cell Biol. 2002;3:155–166
  26. Peinado H, Ballestar E, Esteller M, Cano A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 2004;24:306–319
  27. Kurtz KA, Hoffman HT, Zimmerman MB, Robinson RA. Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head and neck squamous carcinomas. Otolaryngol. Head Neck Surg. 2006;134:142–146
  28. Nair KS, Naidoo R, Chetty R. Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma. Hum. Pathol. 2006;37:125–134
  29. Ueda G, Sunakawa H, Nakamori K, Shinya T, Tsuhako W, Tamura Y, et al. Aberrant expression of beta- and gamma-catenin is an independent prognostic marker in oral squamous cell carcinoma. Int. J. Oral Maxillofac. Surg. 2006;35:356–361
  30. Kudo Y, Ogawa I, Kitagawa M, Kitajima S, Samadarani Siriwardena BS, Aobara N, et al. Establishment and characterization of a spindle cell squamous carcinoma cell line. J. Oral Pathol. Med. 2006;35:479–483
  31. De Craene B, Gilbert B, Stove C, Bruyneel E, van Roy F, Berx G. The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. Cancer Res. 2005;65:6237–6244
  32. Toda S, Yamada S, Aoki S, Inokuchi A, Sugihara H. Air–liquid interface promotes invasive growth of laryngeal squamous cell carcinoma with or without hypoxia. Biochem. Biophys. Res. Commun. 2005;326:866–872
  33. Kinsenn H, Sato H, Furukawa M, Yoshizaki T. Modulation of cell growth and matrix metalloproteinase-2 activation of oral squamous cell carcinoma as a function of culture condition with type I collagen. Acta Otolaryngol. 2003;123:987–993
  34. Matsuyama A, Toda S, Yamada S, Inokuchi A, Sugihara H. Effects of irradiation on biological behavior of carcinoma cells under carcinoma–stromal cell interaction and air–liquid interface: a possible model for testing radiosensitivity of carcinoma of the upper aerodigestive tract using a collagen gel culture system. Pathol. Res. Pract. 2002;198:469–478

PII: S0304-3835(08)00808-2

doi: 10.1016/j.canlet.2008.10.004

Cancer Letters
Volume 275, Issue 1 , Pages 61-71 , 8 March 2009