Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma

Kim, Eun Jung; Che, Zhong Min; Park, Young Jin; Hwang, Young Sun; Kim, Ki Yeol; Jung, Da Woon; Jeon, Nam Kyung; Choi, Young Wook; Lee, Eun Ju; Kim, Jin

doi:10.1016/j.canlet.2008.10.004

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Volume 275, Issue 1 , Pages 61-71, 8 March 2009

Morphogenesis and biological significance of spindle cell transformation in a spindle cell carcinoma

Eun Jung Kim
- Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
Zhong Min Che
- Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
Young Jin Park
- Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
Young Sun Hwang
- Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
Ki Yeol Kim
- Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
Da Woon Jung
- Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
Nam Kyung Jeon
- Electrotechnology Research Institute, Ansan, Republic of Korea
Young Wook Choi
- Electrotechnology Research Institute, Ansan, Republic of Korea
Eun Ju Lee
- Department of Clinical Laboratory Science, Daejeon Health Sciences College, Daejeon, Republic of Korea
Jin Kim
- Oral Cancer Research Institute, Department of Oral Pathology, Brain Korea 21 Project, Yonsei University, College of Dentistry, 134 Shinchon-dong, Seodaemun-Gu, Seoul 120-749, Republic of Korea
- Corresponding author. Tel.: +82 2 2228 3031; fax: +82 2 392 2959.

Received 4 August 2008; received in revised form 25 September 2008; accepted 1 October 2008. published online 10 November 2008.

Abstract

Our study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air–liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior.

Keywords: Spindle cell carcinoma, Invasiveness, Spindle cell transformation, Microenvironment, Epithelial mesenchymal transition