Cancer Letters
Volume 279, Issue 1 , Pages 8-12, 28 June 2009

Emerging role of Notch in stem cells and cancer

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, 9374 Scott Hall, 540 E Canfield, Detroit, MI 48201, United States

Received 21 August 2008; accepted 12 September 2008. published online 20 November 2008.

Abstract 

The Notch signaling pathway is known to be responsible for maintaining a balance between cell proliferation and death and, as such, plays important roles in the formation of many types of human tumors. Recently, Notch signaling pathway has been shown to control stem cell self-renewal and multi-potency. As many cancers are thought to be developed from a number of cancer stem-like cells, which are also known to be linked with the acquisition of epithelial-mesenchymal transition (EMT); and thus suggesting an expanding role of Notch signaling in human tumor progression.

Keywords: Notch, Stem cell, Cancer, Signal pathway

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PII: S0304-3835(08)00801-X

doi:10.1016/j.canlet.2008.09.030

Cancer Letters
Volume 279, Issue 1 , Pages 8-12, 28 June 2009

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