Cancer Letters
Volume 275, Issue 1 , Pages 27-34 , 8 March 2009

A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells

  • Yasuyuki Gen

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Kohichiroh Yasui

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 75 251 5519; fax: +81 75 251 0710.
    • ,
  • Keika Zen

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Tomoaki Nakajima

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Kazuhiro Tsuji

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Mio Endo

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Hironori Mitsuyoshi

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Masahito Minami

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Yoshito Itoh

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Shinji Tanaka

      Affiliations

    • Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Medical and Dental University, Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
    • ,
  • Masafumi Taniwaki

      Affiliations

    • Molecular Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • ,
  • Shigeki Arii

      Affiliations

    • Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Medical and Dental University, Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
    • ,
  • Takeshi Okanoue

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
    • Department of Hepatology, Saiseikai Suita Hospital, Suita, Osaka 564-0013, Japan
    • ,
  • Toshikazu Yoshikawa

      Affiliations

    • Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan

Received 19 August 2008 ,Revised 23 September 2008 ,Accepted 30 September 2008.

References 

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  15. Zrihan-Licht S, Fu Y, Settleman J, Schinkmann K, Shaw L, Keydar I, et al. RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene. 2000;19:1318–1328
  16. Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. Cell Growth Differ. 2000;11:343–354
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PII: S0304-3835(08)00795-7

doi: 10.1016/j.canlet.2008.09.036

Cancer Letters
Volume 275, Issue 1 , Pages 27-34 , 8 March 2009

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