Loss of 1p36, gain of 8q24, and loss of 9q34 are associated with stroma percentage of colorectal cancer

Fijneman, Remond J.A.; Carvalho, Beatriz; Postma, Cindy; Mongera, Sandra; van Hinsbergh, Victor W.M.; Meijer, Gerrit A.

doi:10.1016/j.canlet.2007.09.013

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Volume 258, Issue 2 , Pages 223-229, 18 December 2007

Loss of 1p36, gain of 8q24, and loss of 9q34 are associated with stroma percentage of colorectal cancer

Remond J.A. Fijneman
- Department of Medical Oncology, VU University Medical Center, CCA 2.60, P.O. Box 7057,1007MB Amsterdam, The Netherlands
- Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
- Corresponding author. Address: Department of Medical Oncology, VU University Medical Center, CCA 2.60, P.O. Box 7057, 1007MB Amsterdam, The Netherlands. Tel.: +31 20 4442405; fax: +31 20 4443844.
Beatriz Carvalho
- Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Cindy Postma
- Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Sandra Mongera
- Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Victor W.M. van Hinsbergh
- Department of Medical Oncology, VU University Medical Center, CCA 2.60, P.O. Box 7057,1007MB Amsterdam, The Netherlands
- Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands
Gerrit A. Meijer
- Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

Received 11 June 2007; received in revised form 20 July 2007; accepted 11 September 2007. published online 31 October 2007.

Abstract

Interactions between neoplastic cells and neighboring stromal cells affect tumor morphology and behavior. The present study aimed to identify specific chromosomal aberrations that influence tumor–stroma interactions in colorectal cancer (CRC). Chromosome copy number changes of 23 carcinomas were analyzed by comparative genomic hybridization (array-CGH). Stroma percentage was determined by quantitative measurements of hematoxylin–eosin stained sections. Loss of 1p36 was associated with a decrease, and loss of 9q34 with an increase in CRC stroma percentage. Moreover, gain of 8q24 was associated with increased stroma percentage in CRCs with 20q gain, a major event in colon adenoma-to-carcinoma progression. These data indicate that different cancer genomes have different effects on tumor–stroma interactions, and suggest that determination of specific chromosomal aberrations in CRCs may be used as clinical parameter to predict tumor behavior.

Abbreviations: CRC, colorectal cancer, CGH, comparative genomic hybridization

Keywords: Colorectal cancer, Tumor–stroma interaction, Comparative genomic hybridization