« Previous
Next »
Cancer Letters
Volume 246, Issue 1
, Pages 201-209
, 8 February 2007
Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells
References
- . Xanthohumol and related prenylflavonoids from hops and beer: to your good health. Phytochemistry. 2004;65:1317–1330
- Xanthohumol isolated from humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase. Chem. Res. Toxicol. 2005;18:1296–1305
- Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol. Cancer Ther. 2002;1:959–969
- . Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia. Cancer Lett. 2005;219:215–222
- . Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2. Drug Metab. Dispos. 2000;28:1297–1302
- . Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2′-hydroxychalcones as a novel antioxidant pharmacophore. Chem. Res. Toxicol. 2003;16:1277–1286
- . Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer. Int. J. Cancer. 2005;
- . Inhibitors of nitric oxide production from hops (Humulus Lupulus L.). Biol. Pharm. Bull. 2003;26:61–65
- . Beer constituents as potential cancer chemopreventive agents. Eur. J. Cancer. 2005;
- . Preclinical drug development paradigms for chemopreventives. Hematol. Oncol. Clin. North Am. 1998;12:943–961(see also pages v–vi)
- Cancer prevention by natural compounds. Drug Metab. Pharmacokinet. 2004;19:245–263
- . Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J. Clin. Invest. 2001;107:241–246
- . Aberrant rel/nfkb genes and activity in human cancer. Oncogene. 1999;18:6938–6947
- . Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography–tandem mass spectrometry. J. Chromatogr. A. 1999;832:97–107
- . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 1983;65:55–63
- . Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 1995;182:1545–1556
- . Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res. 2003;63:1254–1261
- . Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. Mol. Nutr. Food Res. 2005;
- . Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism. Mol. Nutr. Food Res. 2005;49:844–850
- . Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J. Mass. Spectrom. 2005;40:289–299
- . Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 1994;12:141–179
- . Rapid activation of NF-kappaB and AP-1 and target gene expression in postischemic rat intestine. Gastroenterology. 2000;118:525–534
- . Intestinal NF-kappaB is activated, mainly as p50 homodimers, by platelet-activating factor. Biochim. Biophys. Acta. 1998;1392:185–192
- . I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell. 1995;80:573–582
- . Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB. J. Biol. Chem. 1998;273:25427–25435
- . The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells. J. Cell Sci. 2002;115:141–151
- . NF-kappa B nuclear localization and its prognostic significance in prostate cancer. BJU Int. 2003;91:417–420
- . Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells. Cancer Res. 2003;63:3495–3502
- . Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells. Prostate. 2002;52:183–200
- . Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells. Cancer Detect. Prev. 2002;26:229–237
- Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem. Toxicol. 1999;37:271–285
- . Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. Cancer Lett. 2000;149:21–29
- . Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Anal. Chem. 2005;77:6407–6414
- . A safety study of oral xanthohumol administration and its influence on fertility in sprague dawley rats. Mol. Nutr. Food Res. 2005;49:861–867
PII: S0304-3835(06)00123-6
doi: 10.1016/j.canlet.2006.02.015
© 2006 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Cancer Letters
Volume 246, Issue 1
, Pages 201-209
, 8 February 2007
