Cancer Letters
Volume 246, Issue 1 , Pages 210-217, 8 February 2007

Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts

Environmental Radiation Research Division, Department of Radiation Biology, Korea Atomic Energy Research Institute, P.O. Box 105, Yusong, Daejeon 305-600, South Korea

Received 31 January 2006; received in revised form 31 January 2006; accepted 20 February 2006.

Abstract 

Combined treatment with the medicinal mushroom Ganoderma lucidum and the herb Duchesnea chrysantha extracts (GDE) causes a synergistic induction of mitochondrial damage and apoptosis in HL-60 cells. GDE treatment is selectively toxic to HL-60 leukemia cells whereas no cytotoxic effect is observed in normal peripheral blood mononuclear cells. GDE-induced apoptosis is associated with Bcl-2 down-regulation, Bax translocation, mitochondrial cytochrome c release and caspase-3 activation, suggesting that apoptosis by this combination occurs through the mitochondria-dependent pathway. The present findings suggest that this combination merits further investigation as a potential therapeutic agent for the treatment of cancer.

Keywords: Apoptosis, Ganoderma lucidum, Duchesnea chrysantha, HL-60, Mitochondria

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PII: S0304-3835(06)00122-4

doi:10.1016/j.canlet.2006.02.014

Cancer Letters
Volume 246, Issue 1 , Pages 210-217, 8 February 2007

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