Cancer Letters
Volume 243, Issue 2 , Pages 211-216, 18 November 2006

MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection

  • Yoshihiro Hamada

      Affiliations

    • Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 92 801 1011; fax: +81 92 861 7300.
    • ,
  • Yoshifuku Nakayama

      Affiliations

    • Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
    • ,
  • Mikiro Mizoguchi

      Affiliations

    • Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
    • ,
  • Seiyo Ikeda

      Affiliations

    • 1st Department of Surgery, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
    • ,
  • Masahide Kuroki

      Affiliations

    • Department of Biochemistry, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
    • ,
  • Hiroshi Iwasaki

      Affiliations

    • Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

Received 2 August 2005; received in revised form 28 October 2005; accepted 27 November 2005.

Abstract 

This retrospective study investigated the prognostic significance of MK-1 expression in human carcinoma of the ampulla of Vater (CAV). Expression was examined immunohistochemically using specimens from 38 patients who underwent surgical treatment for CAV. Expression was found in 61% of samples. Thirteen of 15 well-differentiated but only two of eight poorly differentiated adenocarcinoma were positive (P=0.0352). MK-1 positivity tended to show significantly decreasing pT (P=0.0039), pN (P≤0.001), and pStage (P=0.001). Multivariate analysis showed that MK-1 expression is an independent prognostic marker (P=0.0097) and Kaplan–Meier curves showed a significant relationship with increased overall survival (P=0.0137). These results suggest that MK-1 expression is a prognostic marker of CAV.

Keywords: FU-MK-1, MK-1, Carcinoma of the ampulla of Vater, Predictive factor

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PII: S0304-3835(05)01042-6

doi:10.1016/j.canlet.2005.11.037

Cancer Letters
Volume 243, Issue 2 , Pages 211-216, 18 November 2006

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