Cancer Letters
Volume 243, Issue 2 , Pages 228-234 , 18 November 2006

Immunomodulation and antitumor activity of κ-carrageenan oligosaccharides

  • Huamao Yuan

      Affiliations

    • Institute of Oceanology, Chinese Academy of Sciences, 7 Nanchi Road, Qingdao, Shandong 266071, People's Republic of China
    • ,
  • Jinming Song

      Affiliations

    • Institute of Oceanology, Chinese Academy of Sciences, 7 Nanchi Road, Qingdao, Shandong 266071, People's Republic of China
    • Corresponding Author InformationCorresponding author. Tel./fax: +86 532 289 8583.
    • ,
  • Xuegang Li

      Affiliations

    • Institute of Oceanology, Chinese Academy of Sciences, 7 Nanchi Road, Qingdao, Shandong 266071, People's Republic of China
    • ,
  • Ning Li

      Affiliations

    • Institute of Oceanology, Chinese Academy of Sciences, 7 Nanchi Road, Qingdao, Shandong 266071, People's Republic of China
    • The Graduate School of the Chinese Academy of Science, Beijing 100039, People's Republic of China
    • ,
  • Jicui Dai

      Affiliations

    • Institute of Oceanology, Chinese Academy of Sciences, 7 Nanchi Road, Qingdao, Shandong 266071, People's Republic of China
    • The Graduate School of the Chinese Academy of Science, Beijing 100039, People's Republic of China

Received 23 August 2005 ,Revised 2 November 2005 ,Accepted 27 November 2005.

References 

  1. Ooi VEC, Liu F. Immunomodulation and anticancer activity of polysaccharide–protein complexes. Curr. Med. Chem. 2000;7:715–729
  2. Hiroishi S, Sugie K, Yoshida T, Morimoto J, Taniguchi Y, Imai S, et al. Antitumor effects of Marginisporum crassissimum (rhodophyceae), a marine red alga. Cancer Lett. 2001;167:145–150
  3. Kloareg B, Quatrano RS. Structure of the cell walls of marine algae and ecophysiological functions of the matrix polysaccharides. Oceanogr. Mar. Biol. Annu. Rev. 1988;26:259–315
  4. Alban S, Schauerte A, Franz G. Anticoagulant sulfated polysaccharides: part I. Synthesis and structure–activity relationships of new pullulan sulfates. Carbohydr. Polym. 2002;47:267–276
  5. Suzuki N, Kitazato K, Takamatsu J, Saito H. Antithrombotic and anticoagulant activity of depolymerized fragment of the glycosaminoglycan extracted from Stichopus japonicus Selenka. Thromb. Haemost. 1991;65:369–373
  6. Arfors KE, Ley K. Sulfated polysaccharides in inflammation. J. Lab. Clin. Med. 1993;121:201–202
  7. Caceres PJ, Carlucci MJ, Damonte EB, Matsuhiro B, Zuniga EA. Carrageenans from chilean samples of Stenogramme interrupta (phyllophoraceae): structural analysis and biological activity. Phytochemistry. 2000;53:81–86
  8. Jolles B, Remington M, Andrews PS. Effects of sulphated degraded laminarin on experimental tumor growth. Br. J. Cancer. 1963;17:109–115
  9. Ji MH. Seaweed Chemistry. third ed.. Beijing: Science Press; 1997;pp. 117–196
  10. Santos GA. Carrageenans of species of Eucheuma J. Agardh and Kappaphycus Doty (Solieriaceae, Rhodophyta). Aquat. Bot. 1989;36:55–67
  11. Mclean WM, Williamson FB. kappa-Carrageenan from Pseudomonas carrageenovora. Eur. J. Biochem. 1979;93:553–558
  12. Zhou GF, Sun YP, Xin H, Zhang Y, Li ZE, Xu ZH. In vivo antitumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus. Pharmacol. Res. 2004;50:47–53
  13. Xia J, Piskorz CF, Alderfer JL, Locke RD, Matta KL. Total synthesis of a sialylated and sulfated oligosaccharide from olinked glycoproteins. Tetrahedron Lett. 2000;41:2773–2776
  14. Yuan HM, Song JM. Preparation, structural characterization and in vitro antitumor activity of kappa-carrageenan oligosaccharide fraction from Kappaphycus striatum. J. Appl. Phycol. 2005;17:7–13
  15. Yuan HM, Zhang WW, li XG, Lü XX, Li N, Gao XL, et al. Preparation and in vitro antioxidant activity of κ-carrageenan oligosaccharides and their oversulfated, acetylated, and phosphorylated derivatives. Carbohydr. Res. 2005;340:685–692
  16. Salem ML, Matsuzaki G, Madkour GA, Nomoto K. Beta-estradiol-induced decrease in IL−12 and TNF-α expression suppresses macrophage functions in the course of Listeria monocytogenes infection in mice. Int. J. Immunopharmacol. 1999;21:481–497
  17. Simpson MA, Gozzo JJ. Spectrophotometric determination of lymphocyte mediated sheep red blood cell hemolysis in vitro. J. Immunol. Methods. 1978;21:159–165
  18. Ehrke MJ. Immunomodulation in cancer therapeutics. Int. Immunopharmacol. 2003;3:1105–1119
  19. Weymouth-Wilson AC. The role of carbohydrates in biologically active natural products. Nat. Prod. Rep. 1997;14:99–110
  20. Saksena R, Deepak D, Khare A, Sahai R, Tripathi LM, Srivastava VML. A novel pentasaccharide from immunostimulant oligosaccharide fraction of buffalo milk. Biochim. Biophys. Acta. 1999;1428:433–445
  21. Bland EJ, Keshavarz T, Bucke C. The influence of small oligosaccharides on the immune system. Carbohydr. Res. 2004;339:1673–1678
  22. Zhao G, Kan J, Li Z, Chen Z. Characterization and immunostimulatory activity of an (1→6)-α-d-glucan from the root of Ipomoea batatas. Int. Immunopharmacol. 2005;5:1436–1445
  23. Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from toll-like receptors. Science. 2004;304:1014–1018
  24. Kim KD, Choi SC, Kim A, Choe YK, Choe IS, Lim JS. Dendritic cell-tumor coculturing vaccine can induce antitumor immunity through both NK and CTL interaction. Int. Immunopharmacol. 2001;1:2117–2129
  25. Terlikowski SJ. Local immunotherapy with rhTNF-α mutein induces strong antitumor activity without overt toxicity—a review. Toxicology. 2002;174:143–152
  26. Asano Y, Kaneda K, Hiragushi J, Tsuchida T, Higashino K. The tumor-bearing state induces augmented responses of organ-associated lymphocytes to high-dose interleukin-2 therapy in mice. Cancer Immunol. Immunother. 1997;45:63–70
  27. Kim GY, Choi GS, Lee SH, Park YM. Acidic polysaccharide isolated from phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-α from peritoneal macrophages. J. Ethnopharmacol. 2004;95:69–76
  28. Bohn JA, BeMiller JN. (1→3)-β-d-glucans as biological response modifiers: a review of structure-functional activity relationship. Carbohydr. Polym. 1995;28:3–14
  29. Brown GD, Gordon S. Fungal β-glucans and mammalian immunity. Immunity. 2003;19:311–315
  30. Zhang P, Cheung PCK. Evaluation of sulfated lentinus edodes α-(1→3)-d-Glucan as a potential antitumor agent. Biosci. Biotechnol. Biochem. 2002;66:1052–1056
  31. Ning J, Zhang W, Yi Y, Yang G, Wu Z, Yi J, et al. Synthesis of β-(1→6)-branched β-(1→3) glucohexaose and its analogues containing an α-(1→3) linked bond with antitumor activity. Bioorg. Med. Chem. 2003;11:2193–2203
  32. Yan J, Zong H, Shen A, Chen S, Yin X, Shen X, et al. The β-(1→6)-branched β-(1→3) glucohexaose and its analogues containing an α-(1→3) linked bond have similar stimulatory effects on the mouse spleen as lentinan. Int. Immunopharmacol. 2003;3:1861–1871

PII: S0304-3835(05)01040-2

doi: 10.1016/j.canlet.2005.11.032

Cancer Letters
Volume 243, Issue 2 , Pages 228-234 , 18 November 2006

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