Cancer Letters
Volume 241, Issue 1 , Pages 135-141, 8 September 2006

Cytochrome P450 2A6 polymorphism in nasopharyngeal carcinoma

  • Danai Tiwawech

      Affiliations

    • Research Division, National Cancer Institute, Bangkok 10400, Thailand
    • Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    • ,
  • Petcharin Srivatanakul

      Affiliations

    • Research Division, National Cancer Institute, Bangkok 10400, Thailand
    • ,
  • Anant Karalak

      Affiliations

    • Pathology Division, National Cancer Institute, Bangkok 10400, Thailand
    • ,
  • Takafumi Ishida

      Affiliations

    • Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 5841 4633; fax: +81 3 3818 7547.

Received 11 July 2005; received in revised form 10 October 2005; accepted 12 October 2005.

Abstract 

Nitrosamine has been identified as a carcinogen for nasopharyngeal carcinoma (NPC). Here, we investigated if a nitrosamine metabolizing gene, cytochrome P450 2A6 (CYP2A6) played an important role in NPC development. Relationships between the disease and the CYP2A6 were studied in 74 NPC patients and 137 age-matched healthy controls by using PCR-RFLP assay to distinguish between a wide type allele, *1A, and two mutant alleles, *1B and *4C. Overall, a significant association between CYP2A6 polymorphism and NPC development was observed (P<0.05). Individual with mutant alleles had an increased risk for NPC when compared to those with *1A/*1A (OR=2.37, 95% CI=1.27–4.46). In addition, males who carried mutant alleles of CYP2A6 had a fivefold increased risk for NPC when compared with those who carried *1A/*1A genotype (OR=5.02, 95% CI=1.82–14.14). It is thus suggested that CYP2A6 polymorphism may play a crucial role in NPC susceptibility and it may be used as a risk marker for NPC.

Keywords: Nasopharyngeal carcinoma, CYP2A6, Polymorphism, Nitrosamine

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PII: S0304-3835(05)00944-4

doi:10.1016/j.canlet.2005.10.026

Cancer Letters
Volume 241, Issue 1 , Pages 135-141, 8 September 2006

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