Role of bone morphogenetic proteins in transitional cell carcinoma cells

Received 26 September 2005; received in revised form 8 October 2005; accepted 10 October 2005.

Abstract

Bone morphogenetic proteins (BMPs) are pleiotropic growth factors that signal through an interaction with the membrane receptors—type-IA, -IB, and -II (BMP-RIA, -RIB, and -RII, respectively). Although the prototypical members of this group of growth factors were isolated as osteoinductive factors, recently accumulated data have suggested that these factors regulate malignant cells. Herein, we review the data concerning BMPs in transitional cell carcinoma cells.

Keywords: Bone morphogenetic proteins (BMPs), BMP receptor, Transitional cell carcinoma (TCC), Bladder TCC cell line

a Division of Urologic Oncology, The Cancer Institute of New Jersey, 195 Little Albany Street #4560, New Brunswick, NJ 08903, USA

b Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD, USA

Corresponding author. Tel.: +1 732 235 5184.

PII: S0304-3835(05)00919-5

doi:10.1016/j.canlet.2005.10.009

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