Cancer Letters
Volume 241, Issue 1 , Pages 124-134 , 8 September 2006

Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells

  • Jie Sun

      Affiliations

    • Department of Food Science, Cornell University, 108 Stocking Hall, Ithaca, NY 14853-7201, USA
    • ,
  • Rui Hai Liu

      Affiliations

    • Department of Food Science, Cornell University, 108 Stocking Hall, Ithaca, NY 14853-7201, USA
    • Institute of Comparative and Environmental Toxicology, Ithaca, NY 14853, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853-7201, USA. Tel.: +1 607 255 6235; fax: +1 607 254 4868.

Received 2 August 2005 ,Revised 8 October 2005 ,Accepted 10 October 2005.

References 

  1. ACS Cancer Statistics 2004, A presentation from the American Cancer Society (Ed.), American Cancer Society Inc., Atlanta, 2004.
  2. Lopez-Otin C, Diamandis EP. Breast cancer and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features. Endocr. Rev. 1998;19:365–396
  3. Forbes JF. The control of breast cancer: the role of tamoxifen. Semin. Oncol. 1997;24(Suppl. 1):5–19
  4. Willet WC. Diet, nutrition, and avoidable cancer. Environ. Health Perspect. 1995;103:165–170
  5. Doll R, Peto R. Avoidable risks of cancer in the United States. J. Natl Cancer Inst. 1981;66:1191–1308
  6. Hong WK, Bacus JW. Recent advances in chemoprevention of cancer. Science. 1997;278:1073–1077
  7. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention—a review of the epidemiologic evidence. Nutr. Cancer Int. J. 1992;18:1–29
  8. Liu RH. Health benefits of fruit and vegetables are from aditive and synergistic combinations of phytochemicals. Am. J. Clin. Nutr. 2003;78:517s–520s
  9. Deschner EE, Ruperto J, Wong G, Newmark HL. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis. 1991;7:1193–1196
  10. Wang H, Cao GH, Prior RL. Total antioxidant capacity of fruits. J. Agric. Food Chem. 1996;44:701–705
  11. Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 2001;90:157–177
  12. Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, et al. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J. Natl Cancer Inst. 1996;88:340–348
  13. Rock CL, Demark-Wahnefried W. Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J. Clin. Oncol. 2002;20:3302–3316
  14. Howe GR, Hirohata T, Hislop TG, Iscovich JM, Yuan JM, Katsouyanni K, et al. Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. J. Natl Cancer Inst. 1990;82:561–569
  15. Colditz G, Lipnick R, Branch L, Willett W, Rosner B, Posner B, et al. Increased dietary carotene intake and lowered cancer deaths in an elderly population. Am. J. Epidemiol. 1983;118:454
  16. Block G. Vitamin C and cancer prevention—the epidemiologic evidence. Am. J. Clin. Nutr. 1991;53:S270–S282
  17. Hakkinen S, Heinonen M, Karenlampi S, Mykkanen H, Ruuskanen J, Torronen R. Screening of selected flavonoids and phenolic acids in 19 berries. Food Res. Int. 1999;32:345–353
  18. Kandil FE, Smith MAL, Rogers RB, Pepin M-F, Song LL, Pezzuto JM, et al. Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. J. Agric. Food Chem. 2002;50:1063–1069
  19. Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J. Nutr. 2004;134:3479S–3485S
  20. Howell AB. Cranberry proanthocyanidins and the maintenance of urinary tract health. Crit. Rev. Food Sci. Nutr. 2002;42:273–278
  21. Wilson T, Porcari JP, Harbin D. Cranberry extract inhibits low density lipoprotein oxidation. Life Sci. 1998;62:A381–A386
  22. Reed J. Cranberry flavonoids, atherosclerosis and cardiovascular health. Crit. Rev. Food Sci. Nutr. 2002;42:301–316
  23. Sun J, Chu Y-F, Wu XZ, Liu RH. Antioxidant and antiproliferative activities of common fruits. J. Agric. Food Chem. 2002;50:7449–7454
  24. Chu Y-F, Sun J, Wu XZ, Liu RH. Antioxidant and antiproliferative activities of vegetables. J. Agric. Food Chem. 2002;50:6910–6916
  25. Decker EA. The role of phenolics, conjugated linoleic-acid, carnosine, and pyrroloquinoline quinone as nonessential dietary antioxidants. Nutr. Rev. 1995;53:49–58
  26. Seifried HE, McDonald SS, Andersen DE, Greenwald P, Milner JA. The antioxidant conundrum in cancer. Cancer Res. 2003;63:4295–4298
  27. Tamimi R, Hankinson S, Campos H, Spiegelman D, Zhang S, Colditz G, et al. Plasma carotenoids, retinol and tocopherols and risk of breast cancer. Am. J. Epidemiol. 2005;161:153–160
  28. Mo H, Elson CE. Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J. Nutr. 1999;129:804–813
  29. Agarwal C, Sharma Y, Agarwal R. Anticarcinogenic effect of a polyphnolic fracion isolatd from grape seeds in human prostate carcinoma DU145 cells: cell-cycle regulatiors and induction of G1 arrest and apoptosis. Mol. Carcinog. 2000;28:129–138
  30. Chang W-H, Liu J-J, Ching-Hsein C, Huang T-S, Lu F-J. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by fermented soy milk. Nutr. Cancer. 2002;43:214–226
  31. Behrens P, Brinkmann U, Wellmann A. CSE1L/CAS: its role in proliferation and apoptosis. Apoptosis. 2003;8:39–44
  32. Au JL-S, Panchal N, Li D, Gan Y. Apoptosis: a new pharmacodynamic endpoint. Pharm. Res. 1997;14:1659–1671
  33. Kim YA, Choi BT, Lee YT, Park DI, Rhee SH, Park KY, et al. Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol. Rep. 2004;11:441–446
  34. Dewanto V, Wu XZ, Kafui KA, Liu RH. Thermal processing enhances the nutritional value of tomatoes by increasing total antioxidant activity. J. Agric. Food Chem. 2002;50:3010–3014
  35. Singleton VL, Orthofer R, Lamuela-Raventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin–ciocalteu reagent. Method Enzymol. 1999;299:152–178
  36. Eberhardt MV, Lee CY, Liu RH. Antioxidant activity of fresh apples. Nature. 2000;405:903–904
  37. Wolfe K, Wu XZ, Liu RH. Antioxidant activity of apple peels. J. Agric. Food Chem. 2003;51:609–614
  38. Liu M, Li XQ, Weber C, Liu RH. Antioxidant and antiproliferative activities of raspberries. J. Agric. Food Chem. 2002;50:2926–2930
  39. Willet WC. Diet and health: what should we eat?. Science. 1994;264:532–537
  40. Blot WJ, Li JY, Taylor PR. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl Cancer Inst. 1993;85:1483–1492
  41. Salonen JT, Nyysonen K, Salonen R. Antioxidant supplementation in atherosclerosis prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J. Intern. Med. 2000;248:377–386
  42. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med. 1996;334:1145–1149
  43. Greenberg ER, Baron JA, Stuckel TA, Stevens MM, Mandel JS. A clinical trial of β-carotene to prevent basal cell and squamous cell cancer of the skin. N. Engl. J. Med. 1990;323:789–795
  44. The alpha-tocopherol Beta-carotene Cancer Prevention Study Group . The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 1994;330:1029–1035
  45. Ommen GS, Goodman GE, Thornquist MD. Effects of a combination of β-carotene and vitamin a on lung cancer and cardiovascular disease. N. Engl. J. Med. 1996;334:1150–1155
  46. Bomser J, Madhavi DL, Singletary K, Smith MA. In vitro anticancer activity of fruit extracts from vaccinium species. Planta Med. 1996;62:212–216
  47. Ferguson PJ, Kurowska E, Freeman D, Chambers A, Koropatnick DJ. Cranberry constituents and prostate cancer cell growth. J. Nutr. 2003;133:3843S–3850S
  48. Dixon SC, Sorianon BJ, Lush RM, Borner MM, Figg WD. Apoptosis: its role in the development of malignancies and its potential as a novel therapeutic target. Ann. Pharmacother. 1997;31:76–82
  49. Surh Y-J. Molecular mechanism of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res. 1999;428:305–327
  50. Hartwell LH, Kastan MB. Cell cycle control and cancer. Science. 1994;266:1821–1828
  51. Huschtscha LI, Bartier WA, Anderson Ross CE, Tattersall MHN. Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro. Br. J. Cancer. 1996;73:54–60
  52. Sorensen C, Charpentier R, Benson E. Cell cycle regulatory proteins and structural proteins as markers of apoptosis. Am. Biotechnol. Lab. 2000;17:20–22
  53. Harbour JW, Dean DC. Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2000;2:E65–E67
  54. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht G, Tsai LH, Zhang P, et al. Inhibition of cyclin-dependent kinases by p21. Mol. Biol. Cell. 1995;6:387–400
  55. Liu RH, Liu J, Chen B. Apples prevent mammary tumors in rats. J. Agric. Food Chem. 2005;53:2341–2343

PII: S0304-3835(05)00918-3

doi: 10.1016/j.canlet.2005.10.027

Cancer Letters
Volume 241, Issue 1 , Pages 124-134 , 8 September 2006

Article Tools

* Image Usage & Resolution