Cancer Letters
Volume 241, Issue 1 , Pages 1-12, 8 September 2006

Endocrine disrupting compounds and prostate cancer

  • J.K. Hess-Wilson

      Affiliations

    • Department of Cell Biology, University of Cincinnati College of Medicine, P.O. Box 670521, 3125 Eden Ave., Cincinnati, OH 45267-0521, USA
    • ,
  • K.E. Knudsen

      Affiliations

    • Department of Cell Biology, University of Cincinnati College of Medicine, P.O. Box 670521, 3125 Eden Ave., Cincinnati, OH 45267-0521, USA
    • Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, USA
    • Corresponding Author InformationCorresponding author.Address: Department of Cell Biology, University of Cincinnati College of Medicine, P.O. Box 670521, 3125 Eden Ave., Cincinnati, OH 45267-0521, USA. Tel.: +1 513 558 7371; fax: +1 513 558 4454.

Received 26 September 2005; accepted 7 October 2005.

Abstract 

Prostate cancer is a major health concern and is treated based on its hormone dependence. Agents that alter hormone action can have substantial biological effects on prostate cancer development and progression. As such, there is significant interest in uncovering the potential effects of endocrine disrupting compound (EDC) exposure on prostate cancer. The present review is focused on agents that alter hormone action in the prostate and how they may impact cancer growth or treatment.

Keywords: Endocrine disrupting compound, Prostate cancer, Estrogen, Androgen, Environmental, Phytoestrogen

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PII: S0304-3835(05)00915-8

doi:10.1016/j.canlet.2005.10.006

Cancer Letters
Volume 241, Issue 1 , Pages 1-12, 8 September 2006

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