Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population

Awakura, Yasuo; Ito, Noriyuki; Nakamura, Eijiro; Takahashi, Takeshi; Kotani, Hirokazu; Mikami, Yoshiki; Manabe, Toshiyuki; Kamoto, Toshiyuki; Habuchi, Tomonori; Ogawa, Osamu

doi:10.1016/j.canlet.2005.10.005

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Volume 241, Issue 1 , Pages 59-63, 8 September 2006

Matrix metalloproteinase-9 polymorphisms and renal cell carcinoma in a Japanese population

Yasuo Awakura
- Department of Urology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Noriyuki Ito
- Department of Urology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Eijiro Nakamura
- Department of Urology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Takeshi Takahashi
- Department of Urology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Hirokazu Kotani
- Laboratory of Anatomic Pathology, Kyoto University Hospital, Kyoto, Japan
Yoshiki Mikami
- Laboratory of Anatomic Pathology, Kyoto University Hospital, Kyoto, Japan
Toshiyuki Manabe
- Laboratory of Anatomic Pathology, Kyoto University Hospital, Kyoto, Japan
Toshiyuki Kamoto
- Department of Urology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Tomonori Habuchi
- Department of Urology, Akita University School of Medicine, Akita, Japan
Osamu Ogawa
- Department of Urology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
- Corresponding author. Tel.: +81 75 751 3325; fax: +81 75 761 3441.

Received 27 August 2005; received in revised form 29 September 2005; accepted 7 October 2005.

Abstract

Matrix metalloproteinase-9 (MMP-9) plays a pivotal role in cancer invasion and metastasis. Recently, experimental study has shown that MMP-9 is also implicated in early carcinogenesis. We hypothesized that MMP-9 polymorphisms influence the predisposition to develop renal cell carcinoma (RCC). To test the hypothesis, we determined MMP-9 C−1562T and R279Q genotypes in Japanese RCC cases (n=179) and controls (n=211). Furthermore, we investigated the relationship between MMP-9 polymorphisms and clinicopathological features. The distribution of C−1562T and R279Q genotypes was not significantly associated with the risk of RCC (odds ratio [OR]=1.14, 95% confidence interval [CI]=0.73–1.77 for −1562 CT/TT genotypes versus CC genotype; OR=1.29, 95% CI=0.86–1.93 for 279 RQ/QQ genotypes versus RR genotype). However, the distribution of R279Q genotypes was significantly associated with the histological grade (P<0.01). The present results suggest that MMP9 R279Q polymorphism has influence on the malignant potential of RCC.

Keywords: Kidney, Renal cell carcinoma, MMP-9, Risk, Polymorphisms