Cancer Letters
Volume 241, Issue 1 , Pages 64-68 , 8 September 2006

Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smoke

  • Hanspeter Witschi

      Affiliations

    • Center for Health and the Environment (CHE), University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    • Corresponding Author InformationCorresponding author. Address: 86733 Lower Fourmile Lane, Bandon OR 97411, USA. Tel./fax: +1 541 347 5069.
    • ,
  • Imelda Espiritu

      Affiliations

    • Center for Health and the Environment (CHE), University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    • ,
  • Robert R. Maronpot

      Affiliations

    • National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA

Received 31 August 2005 ,Revised 2 October 2005 ,Accepted 7 October 2005.

References 

  1. Witschi HP. The complexities of an apparently simple lung tumor model: the strain A/J mouse. Exp. Toxicol. Pathol. 2005;57:171–181
  2. Witschi H. Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine. Toxicol. Sci. 2005;84:81–87
  3. Witschi H, Espiritu I, Ly M, Uyeminami D. The chemopreventive effects of orally administered dexamethasone in strain A/J mice following cessation of smoke exposure. Inhal. Toxicol. 2005;17:119–122
  4. Foley JF, Anderson MW, Stoner GD, Gaul BW, Hardisty JF, Maronpot RR. Proliferative lesions of the mouse lung: progression studies in strain A mice. Exp. Lung Res. 1991;17:157–168
  5. Witschi HP, Espiritu I, Maronpot RR, Pinkerton KE, Jones AD. The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis. 1997;18:2035–2042
  6. Shimkin MB, Stoner GD. Lung tumors in mice: application to carcinogenesis bioassay. Adv. Cancer Res. 1975;21:1–58
  7. Stoner GD, Shimkin MB. Lung tumors in strain A mice as a bioassay for carcinogenicity,. In:  Milman H,  Weisburger EK editor. Handbook of Carcinogen Testing. Park Ridge, NJ: Noyes Publications; 1985;p. 179–214
  8. Finch GL, Nikula KJ, Belinsky SA, Barr EB, Stoner GD, Lechner JF. Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse. Cancer Lett. 1996;99:161–167
  9. Witschi HP, Espiritu I, Peake JL, Wu K, Maronpot RR, Pinkerton KE. The carcinogenicity of environmental tobacco smoke. Carcinogenesis. 1997;18:575–586
  10. Stinn W, Teredesai A, Kuhl P, Knoerr-Wittman C, Kindt R, Coggins CRE, et al. Mechanisms involved in A/J mouse lung tumorigenesis induced by inhalation of an environmental tobacco smoke surrogate. Inhal. Toxicol. 2005;17:263–276
  11. Dixon D, Horton J, Haseman JK, Talley F, Greenwell A, Nettesheim P, et al. Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice. Exp. Lung Res. 1991;17:131–155
  12. J.A. Hutt, B.R. Vuillemenot, E.B. Barr, M.J. Grime, F.F. Hahn, C.A. Hobbs, et al., Lifespan inhalation to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways, Carcinogenesis, 26 (2005) 1999–2009.
  13. Mauderly JL, Gigliotti AP, Barr EB, Bechtold WE, Belinsky SA, Hahn FF, et al. Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats. Toxicol. Sci. 2004;81:280–292
  14. Witschi HP. Tobacco smoke as a mouse lung carcinogen. Exp. Lung Res. 1998;24:385–394

PII: S0304-3835(05)00913-4

doi: 10.1016/j.canlet.2005.10.002

Cancer Letters
Volume 241, Issue 1 , Pages 64-68 , 8 September 2006

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